Histidine biosynthesis (WP514)

Saccharomyces cerevisiae

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Histidine is synthesized from phosphoribosyl pyrophosphate (PRPP), which is produced in the pentose phosphate pathway. The first step in the pathway is the condensation of PRPP and ATP by ATP-phosphoribosyl transferase (HIS1). HIS4 then hydrolyzes phosphoribosyl-ATP, which produces phosphoribosyl-AMP (PRAMP). Next, HIS4 catalyzes the formation of phosphoribosylformiminoAICAR-phosphate, which is converted to phosphoribulosylformimino-AICAR-P by the HIS6 gene product. HIS7 splits phosphoribulosylformimino-AICAR-P to form d-erythro-imidazole-glycerol-phosphate. HIS3 forms imidazole acetol-phosphate releasing water. HIS5 then makes l-histidinol-phosphate, which is hydrolyzed by HIS2 making histidinol. HIS4 catalyzes the oxidation of l-histidinol to form l-histidinal. In the last step, l-histidinal is converted to l-histidine. Description adapted from [https://en.wikipedia.org/wiki/Histidine Wikipedia].

Authors

Meredith Braymer , Christine Chichester , Egon Willighagen , Martina Summer-Kutmon , Jeffrey Goessens , Kristina Hanspers , and Eric Weitz

Activity

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

classic metabolic pathway histidine biosynthetic pathway

Participants

Label Type Compact URI Comment
D-erythro-imidazole-glycerol-phosphate Metabolite chebi:58278
L-glutamate Metabolite cas:56-86-0
pyrophosphate Metabolite cas:2466-09-3
Histidinol Metabolite hmdb:HMDB03431
NADH Metabolite cas:53-84-9
L-histidinol phosphate Metabolite chebi:57980
phosphate Metabolite cas:14265-44-2
PRPP Metabolite cas:97-55-2
L-glutamine Metabolite cas:56-85-9
Phosphoribosylformimino-AICAR-Phosphate Metabolite chebi:58435
imidazole acetol-phosphate Metabolite chebi:57766
Phosphoribosyl-ATP Metabolite hmdb:HMDB03665
L-histidine Metabolite cas:71-00-1
Phosphoribulosylformimino-AICAR-P Metabolite hmdb:HMDB12278
ATP Metabolite cas:1927-31-7
AICAR Metabolite cas:3031-94-5
H2O Metabolite hmdb:HMDB02111
Histidinal Metabolite hmdb:HMDB12234
H+ Metabolite chebi:15378
2-oxoglutarate Metabolite chebi:16810
NAD Metabolite chebi:57540
Phosphoribosyl-AMP Metabolite hmdb:HMDB12276
HIS2 GeneProduct sgd:S000001921
HIS1 GeneProduct sgd:S000000857
HIS4 GeneProduct sgd:S000000535
HIS3 GeneProduct sgd:S000005728
HIS7 GeneProduct sgd:S000000452
HIS6 GeneProduct sgd:S000001282
HIS5 GeneProduct sgd:S000001378

References

  1. Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Alifano P, Fani R, Liò P, Lazcano A, Bazzicalupo M, Carlomagno MS, et al. Microbiol Rev. 1996 Mar;60(1):44–69. PubMed Europe PMC Scholia
  2. Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis. Denis V, Boucherie H, Monribot C, Daignan-Fornier B. Mol Microbiol. 1998 Nov;30(3):557–66. PubMed Europe PMC Scholia
  3. Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule. Rébora K, Laloo B, Daignan-Fornier B. Genetics. 2005 May;170(1):61–70. PubMed Europe PMC Scholia
  4. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=HISTSYN-PWY