Spinal cord injury (WP3186)

Bos taurus

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons. An example therapy is the administration of the immunosuppressant FK506, also used in transplantation to offer neuroprotection.

Authors

Martina Summer-Kutmon , Linda Rieswijk , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Disease Ontology

post-traumatic stress disorder spinal cord disease

Pathway Ontology

disease pathway

Cell Type Ontology

astrocyte of the spinal cord

Participants

Label Type Compact URI Comment
LTB4 Metabolite pubchem.compound:169
NO Metabolite pubchem.compound:145068
melittin Metabolite pubchem.compound:16133648
FK506 Metabolite cas:104987-11-3
Arachidonic acid Metabolite hmdb:HMDB0001043
PGH2 Metabolite hmdb:HMDB0001381
Olomoucine Metabolite hmdb:HMDB0035233
2-Methoxyestradiol Metabolite pubchem.compound:66414
PD 168393 Metabolite pubchem.compound:4708
NGFR GeneProduct ensembl:ENSBTAG00000020979 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064300
APEX1 GeneProduct ensembl:ENSBTAG00000002745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100823
MIF GeneProduct ensembl:ENSBTAG00000007375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000240972
OB GeneProduct ensembl:ENSBTAG00000014911 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174697
LGALS3 GeneProduct ensembl:ENSBTAG00000002326 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131981
TNFSF13 GeneProduct ensembl:ENSBTAG00000000130 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161955
LTB4R GeneProduct ensembl:ENSBTAG00000010238 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213903
AQP1 GeneProduct ensembl:ENSBTAG00000000745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000240583
TNFSF13B GeneProduct ensembl:ENSBTAG00000045907 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102524
AIF1 GeneProduct ensembl:ENSBTAG00000020554 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:199
PTPRZ1 GeneProduct ensembl:ENSBTAG00000012119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106278
PDYN GeneProduct ensembl:ENSBTAG00000045520 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101327
LTB GeneProduct ensembl:ENSBTAG00000020674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000227507
PLXNA2 GeneProduct ensembl:ENSBTAG00000001173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076356
CSPG4 GeneProduct ensembl:ENSBTAG00000012219 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173546
CD47 GeneProduct ensembl:ENSBTAG00000003585 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196776
C1QB GeneProduct ensembl:ENSBTAG00000011196 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173369
CDC42 GeneProduct ensembl:ENSBTAG00000001700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
ZFP36 GeneProduct ensembl:ENSBTAG00000008573 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128016
FCGR2C GeneProduct ensembl:ENSBTAG00000038124 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143226
PTPRA GeneProduct ensembl:ENSBTAG00000011425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132670
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
INOS GeneProduct ensembl:ENSBTAG00000006894 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007171
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000232810
NR4A1 GeneProduct ensembl:ENSBTAG00000000507 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123358
IL4 GeneProduct ensembl:ENSBTAG00000015957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113520
BTG2 GeneProduct ensembl:ENSBTAG00000015711 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159388
CDK2 GeneProduct ensembl:ENSBTAG00000004021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123374
NOS1 GeneProduct ensembl:ENSBTAG00000002023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089250
IL2 GeneProduct ensembl:ENSBTAG00000020883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109471
IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244
TLR4 GeneProduct ensembl:ENSBTAG00000006240 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136869
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
EGR1 GeneProduct ensembl:ENSBTAG00000010069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120738
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111537
MBP GeneProduct ensembl:ENSBTAG00000022890 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
RTN4 GeneProduct ensembl:ENSBTAG00000011104 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115310
C5 GeneProduct ensembl:ENSBTAG00000012210 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106804
GRO1 GeneProduct ensembl:ENSBTAG00000037558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163739
CXCL8 GeneProduct ensembl:ENSBTAG00000019716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169429
AQP4 GeneProduct ensembl:ENSBTAG00000019037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171885
ARG1 GeneProduct ensembl:ENSBTAG00000012403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118520
EPHA4 GeneProduct ensembl:ENSBTAG00000010030 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116106
EFNB2 GeneProduct ensembl:ENSBTAG00000016991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125266
CXCL10 GeneProduct ensembl:ENSBTAG00000001725 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169245
CCNG1 GeneProduct ensembl:ENSBTAG00000006607 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113328
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
NCAN GeneProduct ensembl:ENSBTAG00000001764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130287
SLIT1 GeneProduct ensembl:ENSBTAG00000043991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187122
SLIT2 GeneProduct ensembl:ENSBTAG00000005108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145147
SLIT3 GeneProduct ensembl:ENSBTAG00000017746 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184347
NTN1 GeneProduct ensembl:ENSBTAG00000012137 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065320
RGMA GeneProduct ensembl:ENSBTAG00000018603 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182175
CCR2 GeneProduct ensembl:ENSBTAG00000013586 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121807
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115594
IL1A GeneProduct ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
GRO1 GeneProduct ensembl:ENSBTAG00000037558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081041
CCL2 GeneProduct ensembl:ENSBTAG00000037811 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108691
PLA2G6 GeneProduct ensembl:ENSBTAG00000014015 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184381
PLA2G5 GeneProduct ensembl:ENSBTAG00000039122 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127472
PLA2G2A GeneProduct ensembl:ENSBTAG00000005759 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000188257
ANXA1 GeneProduct ensembl:ENSBTAG00000015978 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135046
ICAM1 GeneProduct ensembl:ENSBTAG00000010303 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090339
SELP GeneProduct ensembl:ENSBTAG00000020755 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174175
KLK8 GeneProduct ensembl:ENSBTAG00000015128 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129455
GFAP GeneProduct ensembl:ENSBTAG00000013534 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131095
CDK4 GeneProduct ensembl:ENSBTAG00000046091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135446
NK1R GeneProduct ensembl:ENSBTAG00000015575 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115353
E2F5 GeneProduct ensembl:ENSBTAG00000009378 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133740
RB1 GeneProduct ensembl:ENSBTAG00000006640 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139687
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
E2F1 GeneProduct ensembl:ENSBTAG00000003971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101412
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
CCND1 GeneProduct ensembl:ENSBTAG00000017514 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110092
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
GADD45A GeneProduct ensembl:ENSBTAG00000013860 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116717
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102882
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
CHST11 GeneProduct ensembl:ENSBTAG00000010644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171310
VCAN GeneProduct ensembl:ENSBTAG00000014906 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000038427
COL4A1 GeneProduct ensembl:ENSBTAG00000012849 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187498
XYLT1 GeneProduct ensembl:ENSBTAG00000005523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103489
COL2A1 GeneProduct ensembl:ENSBTAG00000013155 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139219
ACAN GeneProduct ensembl:ENSBTAG00000016158 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157766
BCAN GeneProduct ensembl:ENSBTAG00000015789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132692
SOX9 GeneProduct ensembl:ENSBTAG00000045824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125398
GRIN1 GeneProduct ensembl:ENSBTAG00000047202 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176884
VIM GeneProduct ensembl:ENSBTAG00000018463 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000026025
PPP3CA GeneProduct ensembl:ENSBTAG00000016005 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138814
GAP43 GeneProduct ensembl:ENSBTAG00000006451 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172020
FKBP1A GeneProduct ensembl:ENSBTAG00000032651 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000088832
MAG GeneProduct ensembl:ENSBTAG00000017044 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105695
RHOA GeneProduct ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067560
RHOC GeneProduct ensembl:ENSBTAG00000014299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155366
RHOB GeneProduct ensembl:ENSBTAG00000046054 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143878
ROCK2 GeneProduct ensembl:ENSBTAG00000005847 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134318
OMG GeneProduct ensembl:ENSBTAG00000025213 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126861
RTN4R GeneProduct ensembl:ENSBTAG00000046677 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000040608
LILRB3 GeneProduct ensembl:ENSBTAG00000039932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204577
PGHS-2 GeneProduct ensembl:ENSBTAG00000014127 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
ROS1 GeneProduct ensembl:ENSBTAG00000047600 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6098
NOX4 GeneProduct ensembl:ENSBTAG00000018540 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000086991
CDK1 GeneProduct ensembl:ENSBTAG00000010109 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170312
GDNF GeneProduct ensembl:ENSBTAG00000005176 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168621
SEMA6A GeneProduct ensembl:ENSBTAG00000020489 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000092421
GJA1 GeneProduct ensembl:ENSBTAG00000001835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152661
BDNF GeneProduct ensembl:ENSBTAG00000008134 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176697
RAC1 GeneProduct ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136238
FOXO3 GeneProduct ensembl:ENSBTAG00000011234 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118689
CDKN1B GeneProduct ensembl:ENSBTAG00000018254 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111276
EGFR GeneProduct ensembl:ENSBTAG00000011628 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146648
CASP3 GeneProduct ensembl:ENSBTAG00000015874 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164305

References

  1. Role of cyclooxygenase 2 in acute spinal cord injury. Resnick DK, Graham SH, Dixon CE, Marion DW. J Neurotrauma. 1998 Dec;15(12):1005–13. PubMed Europe PMC Scholia
  2. Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice. Farooque M, Isaksson J, Olsson Y. Neuroreport. 1999 Jan 18;10(1):131–4. PubMed Europe PMC Scholia
  3. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Eng LF, Ghirnikar RS, Lee YL. Neurochem Res. 2000 Oct;25(9–10):1439–51. PubMed Europe PMC Scholia
  4. A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. Tonai T, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, et al. J Neurochem. 2001 Sep;78(5):1064–72. PubMed Europe PMC Scholia
  5. AIF-1 expression defines a proliferating and alert microglial/macrophage phenotype following spinal cord injury in rats. Schwab JM, Frei E, Klusman I, Schnell L, Schwab ME, Schluesener HJ. J Neuroimmunol. 2001 Oct 1;119(2):214–22. PubMed Europe PMC Scholia
  6. Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI. Ann Neurol. 2003 Apr;53(4):454–68. PubMed Europe PMC Scholia
  7. Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Menet V, Prieto M, Privat A, Giménez y Ribotta M. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8999–9004. PubMed Europe PMC Scholia
  8. Stimulation of production of glial cell line-derived neurotrophic factor and nitric oxide by lipopolysaccharide with different dose-responsiveness in cultured rat macrophages. Hashimoto M, Ito T, Fukumitsu H, Nomoto H, Furukawa Y, Furukawa S. Biomed Res. 2005 Oct;26(5):223–9. PubMed Europe PMC Scholia
  9. Macrophage migration inhibitory factor induces cell death and decreases neuronal nitric oxide expression in spinal cord neurons. Chalimoniuk M, King-Pospisil K, Metz CN, Toborek M. Neuroscience. 2006;139(3):1117–28. PubMed Europe PMC Scholia
  10. Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, et al. J Proteome Res. 2006 Apr;5(4):1017–23. PubMed Europe PMC Scholia
  11. Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion. Fabes J, Anderson P, Yáñez-Muñoz RJ, Thrasher A, Brennan C, Bolsover S. Eur J Neurosci. 2006 Apr;23(7):1721–30. PubMed Europe PMC Scholia
  12. Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Tian D shi, Dong Q, Pan D ji, He Y, Yu Z yuan, Xie M jie, et al. Brain Res. 2007 Jun 18;1154:206–14. PubMed Europe PMC Scholia
  13. Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury. Erschbamer M, Pernold K, Olson L. J Neurosci. 2007 Jun 13;27(24):6428–35. PubMed Europe PMC Scholia
  14. TNF-alpha blockage in a mouse model of SCI: evidence for improved outcome. Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muià C, Esposito E, et al. Shock. 2008 Jan;29(1):32–41. PubMed Europe PMC Scholia
  15. Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S. Neuroscience. 2007 Aug 10;148(1):175–87. PubMed Europe PMC Scholia
  16. Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons. Adjan VV, Hauser KF, Bakalkin G, Yakovleva T, Gharibyan A, Scheff SW, et al. Neuroscience. 2007 Sep 7;148(3):724–36. PubMed Europe PMC Scholia
  17. The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury. Chu GKT, Yu W, Fehlings MG. Neuroscience. 2007 Sep 7;148(3):668–82. PubMed Europe PMC Scholia
  18. Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. Liu NK, Zhang YP, Han S, Pei J, Xu LY, Lu PH, et al. J Neuropathol Exp Neurol. 2007 Oct;66(10):932–43. PubMed Europe PMC Scholia
  19. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Brain. 2008 Apr;131(Pt 4):1087–98. PubMed Europe PMC Scholia
  20. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells. Dagci T, Armagan G, Konyalioglu S, Yalcin A. Physiol Res. 2009;58(3):427–34. PubMed Europe PMC Scholia
  21. Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat. Saganová K, Orendácová J, Sulla I Jr, Filipcík P, Cízková D, Vanický I. Cell Mol Neurobiol. 2009 Sep;29(6–7):1045–51. PubMed Europe PMC Scholia
  22. Pathogenic antibodies are active participants in spinal cord injury. Dekaban GA, Thawer S. J Clin Invest. 2009 Oct;119(10):2881–4. PubMed Europe PMC Scholia
  23. Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion. Pineau I, Sun L, Bastien D, Lacroix S. Brain Behav Immun. 2010 May;24(4):540–53. PubMed Europe PMC Scholia
  24. Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation. Puschmann TB, Turnley AM. J Neurochem. 2010 May;113(4):881–94. PubMed Europe PMC Scholia
  25. The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, et al. Am J Pathol. 2010 May;176(5):2352–66. PubMed Europe PMC Scholia
  26. 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Wang Y feng, Fan Z kai, Cao Y, Yu D shui, Zhang Y qiang, Wang Y song. Brain Res. 2011 Jan 25;1370:220–6. PubMed Europe PMC Scholia
  27. CD47 knockout mice exhibit improved recovery from spinal cord injury. Myers SA, DeVries WH, Andres KR, Gruenthal MJ, Benton RL, Hoying JB, et al. Neurobiol Dis. 2011 Apr;42(1):21–34. PubMed Europe PMC Scholia
  28. Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. Jain A, McKeon RJ, Brady-Kalnay SM, Bellamkonda RV. PLoS One. 2011 Jan 24;6(1):e16135. PubMed Europe PMC Scholia
  29. Current and future therapeutic strategies for functional repair of spinal cord injury. Tohda C, Kuboyama T. Pharmacol Ther. 2011 Oct;132(1):57–71. PubMed Europe PMC Scholia
  30. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. J Neurotrauma. 2011 Sep;28(9):1893–907. PubMed Europe PMC Scholia
  31. Repertoire of microglial and macrophage responses after spinal cord injury. David S, Kroner A. Nat Rev Neurosci. 2011 Jun 15;12(7):388–99. PubMed Europe PMC Scholia
  32. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, et al. FASEB J. 2011 Dec;25(12):4240–52. PubMed Europe PMC Scholia
  33. Activated microglia inhibit axonal growth through RGMa. Kitayama M, Ueno M, Itakura T, Yamashita T. PLoS One. 2011;6(9):e25234. PubMed Europe PMC Scholia
  34. Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. Huang C, Han X, Li X, Lam E, Peng W, Lou N, et al. J Neurosci. 2012 Mar 7;32(10):3333–8. PubMed Europe PMC Scholia
  35. Acute leptin treatment enhances functional recovery after spinal cord injury. Fernández-Martos CM, González P, Rodriguez FJ. PLoS One. 2012;7(4):e35594. PubMed Europe PMC Scholia
  36. PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Shim SO, Cafferty WBJ, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM. Mol Cell Neurosci. 2012 Jun;50(2):193–200. PubMed Europe PMC Scholia
  37. Immunosuppressant FK506: focusing on neuroprotective effects following brain and spinal cord injury. Saganová K, Gálik J, Blaško J, Korimová A, Račeková E, Vanický I. Life Sci. 2012 Aug 21;91(3–4):77–82. PubMed Europe PMC Scholia
  38. Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury. Ju P, Zhang S, Yeap Y, Feng Z. Glia. 2012 Nov;60(11):1801–14. PubMed Europe PMC Scholia
  39. Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Pajoohesh-Ganji A, Knoblach SM, Faden AI, Byrnes KR. Brain Res. 2012 Sep 26;1475:96–105. PubMed Europe PMC Scholia
  40. FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat. Zhang S, Huan W, Wei H, Shi J, Fan J, Zhao J, et al. J Cell Biochem. 2013 Feb;114(2):354–65. PubMed Europe PMC Scholia
  41. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, et al. J Neurosci. 2012 Oct 3;32(40):13956–70. PubMed Europe PMC Scholia
  42. Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord. Im YB, Jee MK, Choi JI, Cho HT, Kwon OH, Kang SK. Cell Death Dis. 2012 Nov 15;3(11):e426. PubMed Europe PMC Scholia