Insulin signaling in adipocytes (diabetic condition) (WP3635)
Homo sapiens
The paper describes insulin signaling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signaling under diabetic condition. Insulin signaling under normal condition is represented in WP3634. The model has been converted to GPML using the PathSBML plugin from PathVisio, importing the model BIOMD0000000449 from the BioModels Database directly. The layout has been improved manually.
Authors
Anwesha Bohler , Kristina Hanspers , Andika Tan , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
- Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes (2021).
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Organisms
Homo sapiensCommunities
Annotations
Disease Ontology
diabetes mellitusPathway Ontology
insulin signaling pathwayCell Type Ontology
fat cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Xp | Metabolite | kegg.compound:C00562 | |
| X | Metabolite | chebi:36080 | |
| AS160p | GeneProduct | pato:PATO:0002220 | |
| IRins | Protein | uniprot:P06213 | |
| IR | Protein | uniprot:P06213 | |
| IRp | Protein | uniprot:P06213 | |
| IRip | Protein | uniprot:P06213 | |
| IRi | Protein | uniprot:P06213 | |
| IRS1p | Protein | uniprot:P35568 | |
| IRS1 | Protein | uniprot:P35568 | |
| IRS1p307 | Protein | uniprot:P35568 | |
| mTORC1a | Protein | uniprot:P42345 | |
| IRS1307 | Protein | uniprot:P35568 | |
| mTORC1 | Protein | uniprot:P42345 | |
| PKB308p | Protein | uniprot:P31751 | |
| PKB308p473p | Protein | uniprot:P31751 | |
| mTORC2a | Protein | uniprot:P42345 | |
| mTORC2 | Protein | uniprot:P42345 | |
| PKB | Protein | uniprot:P31751 | |
| PKB473p | Protein | uniprot:P31751 | |
| AS160 | Protein | uniprot:O60343 | |
| GLUT4m | Protein | uniprot:P14672 | |
| GLUT4 | Protein | uniprot:P14672 | |
| S6Kp | Protein | uniprot:P23443 | |
| S6K | Protein | uniprot:P23443 | |
| S6p | Protein | uniprot:P62753 | |
| S6 | Protein | uniprot:P62753 |
References
- Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand EM, Cedersund G, et al. J Biol Chem. 2013 Apr 5;288(14):9867–80. PubMed Europe PMC Scholia