Oxidative damage response (WP3941)
Homo sapiens
This pathway shows how tissue is damaged when oxygen levels are not balanced and become too high. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3941 CPTAC Assay Portal]
Authors
Kristina Hanspers , Eric Weitz , and Egon WillighagenActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
- Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
- Discovering Common Pathogenic Mechanisms of COVID-19 and Parkinson Disease: An Integrated Bioinformatics Analysis (2022).
- A System Biology Approach Reveals New Targets for Human Thyroid Gland Toxicity in Embryos and Adult Individuals (2024).
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
oxidative stress response pathway oxidative stress response pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PCNA | GeneProduct | ensembl:ENSG00000132646 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18538 |
| C1QC | GeneProduct | ensembl:ENSG00000159189 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12262 |
| CDKN1C | GeneProduct | ensembl:ENSG00000129757 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12577 |
| C1QB | GeneProduct | ensembl:ENSG00000173369 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12260 |
| C5AR1 | GeneProduct | ensembl:ENSG00000197405 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12273 |
| TNFRSF1B | GeneProduct | ensembl:ENSG00000028137 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21938 |
| C5 | GeneProduct | ensembl:ENSG00000106804 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15139 |
| TRAF3 | GeneProduct | ensembl:ENSG00000131323 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22031 |
| BCL2 | GeneProduct | ensembl:ENSG00000171791 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12043 |
| CR2 | GeneProduct | ensembl:ENSG00000117322 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12902 |
| BAD | GeneProduct | ensembl:ENSG00000002330 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015 |
| APAF1 | GeneProduct | ensembl:ENSG00000120868 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11783 |
| MAP3K9 | GeneProduct | ensembl:ENSG00000006432 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:338372 |
| MAPK13 | GeneProduct | ensembl:ENSG00000156711 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26415 |
| CDC42 | GeneProduct | ensembl:ENSG00000070831 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12540 |
| TRAF2 | GeneProduct | ensembl:ENSG00000127191 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22030 |
| C4B | GeneProduct | ensembl:ENSG00000224389 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12268 |
| CDKN1A | GeneProduct | ensembl:ENSG00000124762 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12575 |
| C1S | GeneProduct | ensembl:ENSG00000182326 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50908 |
| C1R | GeneProduct | ensembl:ENSG00000159403 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50909 |
| TDP2 | GeneProduct | ensembl:ENSG00000111802 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56196 |
| CYCS | GeneProduct | ensembl:ENSG00000172115 | Rel,Nup93,Nrf1,Them2,Syap1,Zfp259,2700059L22Rik,,Cotl1Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13063 |
| TNK2 | GeneProduct | ensembl:ENSG00000061938 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:51789 |
| C3AR1 | GeneProduct | ensembl:ENSG00000171860 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12267 |
| MAP2K4 | GeneProduct | ensembl:ENSG00000065559 | Xbp1,Mapk10,Klhl8,Mapk10Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26398 |
| BAG4 | GeneProduct | ensembl:ENSG00000156735 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67384 |
| C2 | GeneProduct | ensembl:ENSG00000166278 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12263 |
| CDKN1B | GeneProduct | ensembl:ENSG00000111276 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12576 |
| TRAF1 | GeneProduct | ensembl:ENSG00000056558 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22029 |
| NFKBIE | GeneProduct | ensembl:ENSG00000146232 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18037 |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18033 |
| TNF | GeneProduct | ensembl:ENSG00000232810 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21926 |
| GADD45A | GeneProduct | ensembl:ENSG00000116717 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13197 |
| MAP3K1 | GeneProduct | ensembl:ENSG00000095015 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26401 |
| MAPK10 | GeneProduct | ensembl:ENSG00000109339 | Map2k4,Nlk,Fos,Fzd7,Jund1,ORF19,Map2k4,Dhodh,Map3k7,Dvl3,Eda,Rac1,Jup,Mllt4,Mink1,Myef2,Dusp10,Rala,Etv6,Frk,Wee1,Rexo1Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26414 |
| TRAF6 | GeneProduct | ensembl:ENSG00000175104 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22034 |
| C1QA | GeneProduct | ensembl:ENSG00000173372 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12259 |
| CASP3 | GeneProduct | ensembl:ENSG00000164305 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12367 |
| BAK1 | GeneProduct | ensembl:ENSG00000030110 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12018 |
| CASP9 | GeneProduct | ensembl:ENSG00000132906 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12371 |