Serotonin receptor 2 and ELK-SRF/GATA4 signaling (WP732)

Homo sapiens

This pathway depicts the downstream signaling of serotonin via receptors 2A, 2B, and 2C, resulting in the activation of ELK-SRF and GATA4. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP732 CPTAC Assay Portal]

Authors

Ruke Achoja , Kristina Hanspers , Alex Pico , Thomas Kelder , Allan Kuchinsky , Andra Waagmeester , Egon Willighagen , Zahra Roudbari , Eric Weitz , and Denise Slenter

Activity

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

neuron

Pathway Ontology

serotonin signaling pathway

Participants

Label Type Compact URI Comment
Calcium Metabolite cas:7440-70-2
Serotonin Metabolite cas:50-67-9
1,4,5-Insp3 Metabolite cas:85166-31-0 1,4,5-Insp3
ITPR1 GeneProduct ncbigene:3708 inositol 1,4,5-triphosphate receptor 1
NRAS GeneProduct ncbigene:4893
HRAS GeneProduct ncbigene:3265
RAF1 GeneProduct ncbigene:5894 v-raf-leukemia viral oncogene 1
ELK1 GeneProduct ncbigene:2002 ELK1, member of ETS oncogene family
MAPK1 GeneProduct hgnc.symbol:MAPK1 mitogen activated protein kinase 1
HTR2C GeneProduct ncbigene:3358 5-hydroxytryptamine (serotonin) receptor 2C
MAPKAPK2 GeneProduct ncbigene:9261 MAP kinase-activated protein kinase 2
MAPK3 GeneProduct ncbigene:5595 mitogen activated protein kinase 3
HTR2A GeneProduct ncbigene:3356 5-hydroxytryptamine (serotonin) receptor 2A
GATA4 GeneProduct ncbigene:2626 GATA-binding protein 4/5/6
MAP2K2 GeneProduct ncbigene:5605 mitogen activated protein kinase kinase 2
RASGRF1 GeneProduct ncbigene:5923 RAS protein-specific guanine nucleotide-releasing factor 1
MAP2K1 GeneProduct ncbigene:5604 mitogen activated protein kinase kinase 1
RASGRP1 GeneProduct ncbigene:10125 RAS guanyl releasing protein 1
HTR2B GeneProduct ncbigene:3357 5-hydroxytryptamine (serotonin) receptor 2B
KRAS GeneProduct ncbigene:3845
ELK4 GeneProduct ncbigene:2005 ETS domain-containing protein Elk-4 (SRF accessory protein 1)
GNAQ GeneProduct ncbigene:2776 guanine nucleotide binding protein, alpha q polypeptide
SRF GeneProduct ncbigene:6722 serum response factor
PLC Protein eccode:3.1.4.11 phospholipase C group

References

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