Fatty acid and lipoprotein transport in hepatocytes (WP5323)
Homo sapiens
This model was constructed integrating the Fatty acid transporters (Homo sapiens) metapathway (WP5061), the Cholesterol metabolism (Homo sapiens) (WP5304) and the KEGG Cholesterol metabolism pathway (map04979) as well as information from the literature.
Authors
Luiz C. M. Ladeira , Martina Summer-Kutmon , Egon Willighagen , Denise Slenter , Javier Millán Acosta , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
classic metabolic pathwayCell Type Ontology
hepatocyte centrilobular region hepatocyte| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Long-chain fatty acid | Metabolite | chebi:15904 | |
| Fatty acyl-CoA | Metabolite | chebi:37554 | |
| Cholesterol ester | Metabolite | chebi:17002 | |
| Triacylglycerol | Metabolite | chebi:17855 | |
| Phospholipids | Metabolite | chebi:16247 | |
| Phospholipid | Metabolite | chebi:16247 | |
| Cholesterol | Metabolite | chebi:16113 | |
| CoA | Metabolite | chebi:15346 | |
| APOB | Protein | ncbigene:338 | |
| APOE | Protein | ensembl:ENSG00000130203 | |
| APOC1 | Protein | refseq:NM_001321065 | |
| APOA1 | Protein | hgnc:600 | |
| APOA2 | Protein | hgnc:601 | |
| LRPAP1 | Protein | hgnc:6701 | |
| SORT1 | Protein | ncbigene:6272 | |
| MYLIP | Protein | refseq:NM_013262 | |
| DBI | Protein | hgnc.symbol:DBI | ACBP acyl-CoA binding protein Approved symbol: DBI Previous names: diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2690 |
| LIPA | Protein | hgnc.symbol:LIPA | |
| NPC2 | Protein | ensembl:ENSG00000119655 | |
| TSPO | Protein | hgnc:1158 | |
| LCAT | Protein | hgnc:6522 | |
| SCARB1 | Protein | uniprot:Q8WTV0 | |
| ABCA1 | Protein | refseq:NM_005502 | |
| MTTP | Protein | hgnc:7467 | |
| APOA4 | Protein | hgnc.symbol:APOA4 | |
| LPA | Protein | ensembl:ENSG00000198670 | |
| APOC2 | Protein | uniprot:P02655 | |
| APOC3 | Protein | hgnc:610 | |
| LDLRAP1 | Protein | ensembl:ENSG00000157978 | |
| LDLR | Protein | hgnc.symbol:LDLR | |
| PCSK9 | Protein | uniprot:Q8NBP7 | |
| LRP1 | Protein | refseq:NM_002332 | |
| SLC27A2 | Protein | ncbigene:11001 | |
| SLC27A4 | Protein | ensembl:ENSG00000167114 | |
| SLC27A3 | Protein | refseq:NM_024330 | |
| SLC27A5 | Protein | hgnc:10999 | |
| SLC27A1 | Protein | ncbigene:376497 | |
| STARD3 | Protein | uniprot:Q14849 | |
| VDAC1 | Protein | ensembl:ENSG00000213585 | |
| VAPA | Protein | hgnc:12648 | |
| NPC1 | Protein | hgnc:7897 | |
| OSBPL5 | Protein | ensembl:ENSG00000021762 | |
| ACSL1 | Protein | ncbigene:2180 | |
| ACSL3 | Protein | refseq:NM_004457 | |
| ACSL4 | Protein | hgnc:3571 | |
| ACSL5 | Protein | ensembl:ENSG00000197142 | |
| ACSL6 | Protein | ensembl:ENSG00000164398 | |
| FABP2 | Protein | refseq:NM_000134 | |
| FABP3 | Protein | ensembl:ENSG00000121769 | |
| FABP5 | Protein | hgnc:3560 | |
| FABP1 | Protein | refseq:NM_001443 | |
| FABP4 | Protein | refseq:NM_001442 | |
| DBI | Protein | hgnc.symbol:DBI | |
| SOAT1 | Protein | hgnc.symbol:SOAT1 | |
| SOAT2 | Protein | refseq:NM_003578 | |
| STAR | Protein | hgnc.symbol:STAR | |
| CD36 | Protein | hgnc:1663 |
References
- A current review of fatty acid transport proteins (SLC27). Stahl A. Pflugers Arch. 2004 Feb;447(5):722–7. PubMed Europe PMC Scholia
- Liver lipid metabolism. Nguyen P, Leray V, Diez M, Serisier S, Le Bloc’h J, Siliart B, et al. J Anim Physiol Anim Nutr (Berl). 2008 Jun;92(3):272–83. PubMed Europe PMC Scholia