Trans-sulfuration, one-carbon metabolism and related pathways (WP2525)
Homo sapiens
This pathway shows the (one) carbon metabolism over grey and related pathways around it. The one carbon donor pathway (WP2190) has been added to this one (additional conversions are coloured green for clarity of the origin); as well as WP3940 (overlapping content in bold), which was based on [https://www.genome.jp/dbget-bin/www_bget?pathway+mmu00270 KEGG] and inferred from Mus musculus pathway [http://wikipathways.org/instance/WP1770_r96326 WP1770_96326] with a 100.0% conversion rate. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2525 CPTAC Assay Portal].
Authors
Liang Zhao , Martina Summer-Kutmon , Kristina Hanspers , Marianthi Kalafati , Jesse Vercoulen , Denise Slenter , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation (2023).
- Bioinformatics analysis of the pathogenic link between Epstein-Barr virus infection, systemic lupus erythematosus and diffuse large B cell lymphoma (2023).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
classic metabolic pathway folate mediated one-carbon metabolic pathway folate metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 3P-Glycerate | Metabolite | kegg.compound:C00597 | |
| 3P-Hydroxypyruvate | Metabolite | kegg.compound:C03232 | |
| Phosphoserine | Metabolite | kegg.compound:C01005 | |
| THF | Metabolite | kegg.compound:C00101 | |
| dUMP | Metabolite | kegg.compound:C00365 | |
| 5,10-Methenyl-THF | Metabolite | kegg.compound:C00445 | |
| 10-Formyl-THF | Metabolite | kegg.compound:C00234 | |
| 5,10-Methylene-THF | Metabolite | kegg.compound:C00143 | |
| Dihydrofolate | Metabolite | kegg.compound:C00415 | |
| dTMP | Metabolite | kegg.compound:C00364 | |
| Putrescine | Metabolite | hmdb:HMDB0001414 | |
| Decarboxylated SAM | Metabolite | pubchem.compound:25203490 | |
| Cysteine sulphinate | Metabolite | pubchem.compound:6409687 | |
| Ornithine | Metabolite | hmdb:HMDB0000214 | |
| Spermine | Metabolite | hmdb:HMDB0001256 | |
| Spermidine | Metabolite | hmdb:HMDB0001257 | |
| S-Adenosylhomocysteine | Metabolite | kegg.compound:C00021 | |
| Total Phospholipids | Metabolite | chebi:16247 | |
| L-Methionine | Metabolite | hmdb:HMDB0000696 | |
| 3-Sulfinoalanine | Metabolite | kegg.compound:C00606 | |
| L-Cysteine | Metabolite | kegg.compound:C00097 | |
| NADP | Metabolite | kegg.compound:C00006 | |
| Hypotaurine | Metabolite | kegg.compound:C00519 | |
| Glutathione (GSH) | Metabolite | kegg.compound:C00051 | |
| Tetrahydrofolic acid | Metabolite | kegg.compound:C00101 | aka THF |
| Phosphocholine | Metabolite | chebi:18132 | |
| Ethanolamine | Metabolite | kegg.compound:C00189 | |
| Taurocholic acid | Metabolite | kegg.compound:C05122 | |
| Glutathione disulfide (GSSG) | Metabolite | kegg.compound:C00127 | |
| 5,10-Methenyltetrahydrofolic acid | Metabolite | kegg.compound:C00445 | |
| Taurochenodesoxycholic acid | Metabolite | kegg.compound:C05465 | |
| Glutamate | Metabolite | kegg.compound:C00217 | |
| CDP-choline | Metabolite | kegg.compound:C00307 | |
| O-Phosphoethanolamine | Metabolite | kegg.compound:C00346 | |
| Phosphatidylethanolamine | Metabolite | kegg.compound:C00350 | |
| Dimethylglycine | Metabolite | kegg.compound:C01026 | |
| Betaine | Metabolite | kegg.compound:C00719 | |
| Phosphatidylcholines | Metabolite | cas:8002-43-5 | |
| L-Serine | Metabolite | kegg.compound:C00065 | |
| Taurine | Metabolite | kegg.compound:C00245 | |
| NADPH | Metabolite | kegg.compound:C00005 | |
| Sarcosine | Metabolite | kegg.compound:C00213 | |
| CDP-Ethanolamine | Metabolite | kegg.compound:C00570 | |
| 10-formyldihydrofolate | Metabolite | hmdb:HMDB0006485 | |
| 5-oxoproline | Metabolite | kegg.compound:C01879 | |
| 5-Methyltetrahydrofolic acid | Metabolite | kegg.compound:C00440 | |
| L-Cystathionine | Metabolite | kegg.compound:C02291 | |
| Folic acid | Metabolite | kegg.compound:C00504 | |
| S-Adenosylmethionine | Metabolite | kegg.compound:C00019 | |
| Homocysteine | Metabolite | kegg.compound:C05330 | |
| Glycine | Metabolite | kegg.compound:C00037 | |
| Choline | Metabolite | kegg.compound:C00114 | |
| gamma-Glutamylcysteine | Metabolite | kegg.compound:C00669 | |
| 2-oxobutanoate | Metabolite | chebi:16763 | |
| (S)-2-Aminobutanoate | Metabolite | chebi:35619 | |
| gamma-L-Glutamyl-L-2-aminobutyrate | Metabolite | pubchem.compound:7014903 | |
| Ophthalmate | Metabolite | pubchem.compound:7018721 | |
| Acetylcholine | Metabolite | hmdb:HMDB0000895 | |
| Glutathione | Metabolite | kegg.compound:C00051 | |
| Betainealdehyde | Metabolite | chebi:15710 | |
| PHGDH | GeneProduct | ncbigene:26227 | |
| PSAT1 | GeneProduct | ncbigene:29968 | |
| PSPH | GeneProduct | ncbigene:5723 | |
| TYMS | GeneProduct | ncbigene:7298 | |
| DHFR | GeneProduct | ncbigene:1719 | |
| DHFRL1 | GeneProduct | ncbigene:200895 | |
| MTHFD1 | GeneProduct | ncbigene:4522 | |
| MTHFD2 | GeneProduct | ncbigene:10797 | |
| MTHFD2L | GeneProduct | ncbigene:441024 | |
| MTHFD1L | GeneProduct | ncbigene:25902 | |
| MTHFD1L | GeneProduct | ncbigene:1719 | |
| MTR | GeneProduct | ncbigene:4548 | |
| BHMT | GeneProduct | ncbigene:635 | |
| CBS | GeneProduct | ncbigene:875 | |
| GSS | GeneProduct | ncbigene:2937 | |
| GCLC | GeneProduct | ncbigene:2729 | |
| GCLM | GeneProduct | ncbigene:2730 | |
| ETNK2 | GeneProduct | ensembl:ENSG00000143845 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253 |
| GPX5 | GeneProduct | ensembl:ENSG00000224586 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14780 |
| SOD1 | GeneProduct | ensembl:ENSG00000142168 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20655 |
| CSAD | GeneProduct | ensembl:ENSG00000139631 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:246277 |
| CHPT1 | GeneProduct | ensembl:ENSG00000111666 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862 |
| DHFR2 | GeneProduct | ensembl:ENSG00000178700 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13361 |
| PCYT1A | GeneProduct | ensembl:ENSG00000161217 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026 |
| MAT2A | GeneProduct | ensembl:ENSG00000168906 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:232087 |
| GSR | GeneProduct | ensembl:ENSG00000104687 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14782 |
| PCYT1B | GeneProduct | ensembl:ENSG00000102230 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899 |
| ETNK1 | GeneProduct | ensembl:ENSG00000139163 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320 |
| CEPT1 | GeneProduct | ensembl:ENSG00000134255 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712 |
| SOD3 | GeneProduct | ensembl:ENSG00000109610 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20657 |
| MAT1A | GeneProduct | ensembl:ENSG00000151224 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11720 |
| GPX7 | GeneProduct | ensembl:ENSG00000116157 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67305 |
| CTH | GeneProduct | ensembl:ENSG00000116761 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107869 |
| GSS | GeneProduct | ensembl:ENSG00000100983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14854 |
| CHDH | GeneProduct | ensembl:ENSG00000016391 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218865 |
| DNMT3A | GeneProduct | ensembl:ENSG00000119772 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13435 |
| BHMT2 | GeneProduct | ensembl:ENSG00000132840 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64918 |
| MTHFR | GeneProduct | ensembl:ENSG00000177000 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17769 |
| DNM1 | GeneProduct | ensembl:ENSG00000106976 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13429 |
| PLD1 | GeneProduct | ensembl:ENSG00000075651 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805 |
| SOD2 | GeneProduct | ensembl:ENSG00000112096 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20656 |
| GPX6 | GeneProduct | ensembl:ENSG00000198704 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75512 |
| CHKB | GeneProduct | ensembl:ENSG00000100288 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651 |
| GAD1 | GeneProduct | ensembl:ENSG00000128683 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14415 |
| CDO1 | GeneProduct | ensembl:ENSG00000129596 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12583 |
| GAD2 | GeneProduct | ensembl:ENSG00000136750 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14417 |
| GNMT | GeneProduct | ensembl:ENSG00000124713 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14711 |
| BHMT | GeneProduct | ensembl:ENSG00000145692 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12116 |
| SHMT1 | GeneProduct | ensembl:ENSG00000176974 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20425 |
| PCYT2 | GeneProduct | ensembl:ENSG00000185813 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671 |
| SARDH | GeneProduct | ensembl:ENSG00000123453 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192166 |
| GPX4 | GeneProduct | ensembl:ENSG00000167468 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:625249 |
| GPX2 | GeneProduct | ensembl:ENSG00000176153 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14776 |
| GPX1 | GeneProduct | ensembl:ENSG00000233276 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14775 |
| MTR | GeneProduct | ensembl:ENSG00000116984 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:238505 |
| GCLM | GeneProduct | ensembl:ENSG00000023909 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14630 |
| GPX3 | GeneProduct | ensembl:ENSG00000211445 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14778 |
| AHCYL1 | GeneProduct | ensembl:ENSG00000168710 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:229709 |
| CBSL | GeneProduct | ensembl:ENSG00000274276 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12411 |
| DMGDH | GeneProduct | ensembl:ENSG00000132837 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74129 |
| BAAT | GeneProduct | ensembl:ENSG00000136881 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12012 |
| SHMT2 | GeneProduct | ensembl:ENSG00000182199 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108037 |
| CHKA | GeneProduct | ensembl:ENSG00000110721 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660 |
| TYMS | GeneProduct | ensembl:ENSG00000176890 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22171 |
| GCLC | GeneProduct | ensembl:ENSG00000001084 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14629 |
| PEMT | GeneProduct | ensembl:ENSG00000133027 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618 |
| BCAT1 | GeneProduct | ensembl:ENSG00000060982 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030268 |
| AGXT2 | GeneProduct | ensembl:ENSG00000113492 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000089678 |
| GCLC | GeneProduct | ensembl:ENSG00000001084 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032350 |
| GSS | GeneProduct | ensembl:ENSG00000100983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027610 |
| BCAT2 | GeneProduct | ensembl:ENSG00000105552 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030826 |
| GCLM | GeneProduct | ensembl:ENSG00000023909 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028124 |
| AMT | GeneProduct | ncbigene:275 | |
| MAT2B | GeneProduct | ncbigene:27430 | |
| DNMT3B | GeneProduct | ncbigene:1789 | |
| DNMT3L | GeneProduct | ncbigene:29947 | |
| AHCY | GeneProduct | ncbigene:191 | |
| AHCYL2 | GeneProduct | ncbigene:23382 | |
| ALDH7A1 | GeneProduct | ensembl:ENSG00000164904 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218865 |
| SLC25A48 | GeneProduct | ensembl:ENSG00000145832 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805 |
References
- One-Carbon Metabolism in Health and Disease. Ducker GS, Rabinowitz JD. Cell Metab. 2017 Jan 10;25(1):27–42. PubMed Europe PMC Scholia
- Mitochondrial choline import regulates purine nucleotide pools via SLC25A48. Verkerke ARP, Shi X, Abe I, Gerszten RE, Kajimura S. bioRxiv. 2024 Jan 1;2023.12.31.573776. PubMed Europe PMC Scholia