Sphingolipid metabolism overview (WP4344)
Mus musculus
This pathway is inspired by the Lipidmaps>Sphingolipids pathway [https://lipidmaps.org/pathway/pathways_maps]. Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide. All products are annotated with a lipid-class identifier. The integrated pathway can be found [https://www.wikipathways.org/index.php/Pathway:WP4690 here].
Authors
Denise Slenter , Egon Willighagen , and Eric WeitzActivity
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Organisms
Mus musculusCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
sphingolipid biosynthetic pathway sphingomyelin metabolic pathway sphingolipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ATP | Metabolite | chebi:30616 | |
| 3-keto-sphinganine | Metabolite | lipidmaps:LMSP01020002 | |
| Palmitoyl-CoA | Metabolite | lipidmaps:LMFA07050360 | aka CoA(16:0) |
| Serine | Metabolite | pubchem.compound:5951 | |
| Hexadecanal | Metabolite | lipidmaps:LMFA06000088 | |
| Ethanolamine-phosphate | Metabolite | pubchem.compound:1015 | |
| H2O | Metabolite | chebi:15377 | |
| Sphingosine | Metabolite | lipidmaps:LMSP01010001 | |
| Sphinganine | Metabolite | lipidmaps:LMSP01020001 | |
| Sphinganine-1-phosphate | Metabolite | lipidmaps:LMSP01050002 | |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 | |
| Ceramide | Metabolite | lipidmaps:LMSP02010000 | |
| Cer-1-P | Metabolite | lipidmaps:LMSP02050000 | |
| DH-Cer-1-P | Metabolite | lipidmaps:LMSP020500A0 | |
| SM | Metabolite | lipidmaps:LMSP0301 | |
| Glc-Cer | Metabolite | lipidmaps:LMSP0501AA00 | |
| DH-SM | Metabolite | lipidmaps:LMSP030100A0 | |
| Gal-Cer | Metabolite | lipidmaps:LMSP0501AC00 | |
| Sphingosine-1-phosphate | Metabolite | lipidmaps:LMSP01050001 | |
| 1-Hexadecenal | Metabolite | lipidmaps:LMFA06000088 | |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 | |
| CoA(18:0) | Metabolite | chebi:15541 | |
| CoA(20:0) | Metabolite | chebi:15527 | |
| CoA(22:0) | Metabolite | cas:24330-89-0 | |
| CoA(24:0) | Metabolite | cas:24305-30-4 | |
| CoA(24:1) | Metabolite | cas:88362-35-0 | |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 | |
| CoA(18:0) | Metabolite | chebi:15541 | |
| CoA(20:0) | Metabolite | chebi:15527 | |
| CoA(22:0) | Metabolite | cas:24330-89-0 | AKA 'Coenzyme A, S-docosanoate' |
| CoA(24:0) | Metabolite | cas:24305-30-4 | AKA 'Coenzyme A, S-(tetracosanoate)' |
| CoA(24:1) | Metabolite | cas:88362-35-0 | AKA 'Coenzyme A, S-(15Z)-15-tetracosenoate' |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 | |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 | |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 | |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 | |
| CoA(26:0) | Metabolite | cas:99313-57-2 | AKA 'Coenzyme A, S-hexacosanoate' |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 | |
| CoA(26:0) | Metabolite | cas:99313-57-2 | |
| ADP | Metabolite | chebi:456216 | |
| Ppap2a | Protein | ncbigene:19012 | |
| Cerk | Protein | ncbigene:223753 | |
| Sgpp1 | Protein | uniprot:Q9JI99 | |
| Asah1 | Protein | uniprot:Q9WV54 | |
| Sgms1 | Protein | ncbigene:208449 | |
| Sphk2 | Protein | uniprot:Q9JIA7 | |
| Sgpl1 | Protein | ncbigene:20397 | |
| Ugcg | Protein | ncbigene:22234 | |
| Sptlc1 | Protein | ncbigene:268656 | |
| Sphk1 | Protein | uniprot:Q8CI15 | |
| Degs1 | Protein | ncbigene:13244 | |
| Kdsr | Protein | uniprot:Q6GV12 | |
| Sptlc2 | Protein | uniprot:P97363 | |
| CerS4 | Protein | ncbigene:67260 | |
| CerS5 | Protein | ncbigene:67260 | |
| CerS6 | Protein | ncbigene:241447 | |
| Smpd1 | Protein | ncbigene:20597 | |
| Degs2 | Protein | ncbigene:70059 | |
| Sgms2 | Protein | ncbigene:74442 | |
| Ppap2b | Protein | ncbigene:67916 | |
| Ppap2c | Protein | ncbiprotein:50784 | |
| Ugt8a | Protein | ncbigene:22239 | |
| CerS1 | Protein | uniprot:P27545 | |
| CerS4 | Protein | ncbigene:67260 | |
| Cers2 | Protein | ncbigene:76893 | |
| Cers3 | Protein | uniprot:Q1A3B0 | |
| Sgpp2 | Protein | uniprot:Q810K3 |
References
- Characterization of murine sphingosine-1-phosphate phosphohydrolase. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
- De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. Merrill AH Jr. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia