Sphingolipid metabolism overview (WP4344)

Mus musculus

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This pathway is inspired by the Lipidmaps>Sphingolipids pathway [https://lipidmaps.org/pathway/pathways_maps]. Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide. All products are annotated with a lipid-class identifier. The integrated pathway can be found [https://www.wikipathways.org/index.php/Pathway:WP4690 here].

Authors

Denise Slenter , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

sphingolipid biosynthetic pathway sphingomyelin metabolic pathway sphingolipid metabolic pathway

Participants

Label Type Compact URI Comment
ATP Metabolite chebi:30616
3-keto-sphinganine Metabolite lipidmaps:LMSP01020002
Palmitoyl-CoA Metabolite lipidmaps:LMFA07050360 aka CoA(16:0)
Serine Metabolite pubchem.compound:5951
Hexadecanal Metabolite lipidmaps:LMFA06000088
Ethanolamine-phosphate Metabolite pubchem.compound:1015
H2O Metabolite chebi:15377
Sphingosine Metabolite lipidmaps:LMSP01010001
Sphinganine Metabolite lipidmaps:LMSP01020001
Sphinganine-1-phosphate Metabolite lipidmaps:LMSP01050002
DH-Ceramide Metabolite lipidmaps:LMSP02020000
Ceramide Metabolite lipidmaps:LMSP02010000
Cer-1-P Metabolite lipidmaps:LMSP02050000
DH-Cer-1-P Metabolite lipidmaps:LMSP020500A0
SM Metabolite lipidmaps:LMSP0301
Glc-Cer Metabolite lipidmaps:LMSP0501AA00
DH-SM Metabolite lipidmaps:LMSP030100A0
Gal-Cer Metabolite lipidmaps:LMSP0501AC00
Sphingosine-1-phosphate Metabolite lipidmaps:LMSP01050001
1-Hexadecenal Metabolite lipidmaps:LMFA06000088
CoA(16:0) Metabolite lipidmaps:LMFA07050360
CoA(18:0) Metabolite chebi:15541
CoA(20:0) Metabolite chebi:15527
CoA(22:0) Metabolite cas:24330-89-0
CoA(24:0) Metabolite cas:24305-30-4
CoA(24:1) Metabolite cas:88362-35-0
CoA(22:0) Metabolite cas:24330-89-0 AKA 'Coenzyme A, S-​docosanoate'
CoA(24:0) Metabolite cas:24305-30-4 AKA 'Coenzyme A, S-​(tetracosanoate)​'
CoA(24:1) Metabolite cas:88362-35-0 AKA 'Coenzyme A, S-​(15Z)​-​15-​tetracosenoate'
CoA(26:0) Metabolite cas:99313-57-2 AKA 'Coenzyme A, S-​hexacosanoate'
CoA(26:0) Metabolite cas:99313-57-2
ADP Metabolite chebi:456216
Ppap2a Protein ncbigene:19012
Cerk Protein ncbigene:223753
Sgpp1 Protein uniprot:Q9JI99
Asah1 Protein uniprot:Q9WV54
Sgms1 Protein ncbigene:208449
Sphk2 Protein uniprot:Q9JIA7
Sgpl1 Protein ncbigene:20397
Ugcg Protein ncbigene:22234
Sptlc1 Protein ncbigene:268656
Sphk1 Protein uniprot:Q8CI15
Degs1 Protein ncbigene:13244
Kdsr Protein uniprot:Q6GV12
Sptlc2 Protein uniprot:P97363
CerS4 Protein ncbigene:67260
CerS5 Protein ncbigene:67260
CerS6 Protein ncbigene:241447
Smpd1 Protein ncbigene:20597
Degs2 Protein ncbigene:70059
Sgms2 Protein ncbigene:74442
Ppap2b Protein ncbigene:67916
Ppap2c Protein ncbiprotein:50784
Ugt8a Protein ncbigene:22239
CerS1 Protein uniprot:P27545
Cers2 Protein ncbigene:76893
Cers3 Protein uniprot:Q1A3B0
Sgpp2 Protein uniprot:Q810K3

References

  1. Characterization of murine sphingosine-1-phosphate phosphohydrolase. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
  2. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. Merrill AH Jr. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
  3. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia