G13 signaling pathway

Anita Chow; WikiPathways Maintenance bot; Thomas Kelder; Christine Chichester; Kristina Hanspers; Egon Willighagen; Eric Weitz

G13 signaling pathway (WP298)

Mus musculus

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]]

Authors

Anita Chow , Thomas Kelder , Christine Chichester , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway via Galpha12/Galpha13 family

Participants

Label	Type	Compact URI	Comment
Limk1	GeneProduct	ncbigene:16885
Gna13	GeneProduct	ncbigene:14674
Arhgef1	GeneProduct	ncbigene:16801
Rhoa	GeneProduct	ncbigene:11848
Pik3r2	GeneProduct	ncbigene:18709
Diap1	GeneProduct	ncbigene:13367
Pfn1	GeneProduct	ncbigene:18643
Pip4k2a	GeneProduct	ncbigene:18718
Mapk10	GeneProduct	ncbigene:26414
Pkn1	GeneProduct	ncbigene:320795
Mybph	GeneProduct	ncbigene:53311
Ppp1cb	GeneProduct	ncbigene:19046
Arhgdib	GeneProduct	ncbigene:11857
Rac1	GeneProduct	ncbigene:19353
Map3k4	GeneProduct	ncbigene:26407
Pak3	GeneProduct	ncbigene:18481
Myl1	GeneProduct	ncbigene:17901
Cit	GeneProduct	ncbigene:12704
Iqgap1	GeneProduct	ncbigene:29875
Iqgap2	GeneProduct	ncbigene:544963
Rps6kb1	GeneProduct	ncbigene:72508	A41687
Rock1	GeneProduct	ncbigene:19877	S69211
Rock2	GeneProduct	ncbigene:19878	BAA31594
Sh3rf1	GeneProduct	ncbigene:59009	Posh
Pik3ca	GeneProduct	ncbigene:18706
Pik3cb	GeneProduct	ncbigene:74769
Pik3cd	GeneProduct	ncbigene:18707	P42338
Cfl2	GeneProduct	ncbigene:12632
Cfl1	GeneProduct	ncbigene:12631
Rtkn	GeneProduct	ncbigene:20166
Rhpn2	GeneProduct	ncbigene:52428
Arhgdig	GeneProduct	ncbigene:14570
Calm1	GeneProduct	ncbigene:12313
Tnk2	GeneProduct	ncbigene:51789	S33596
Cdc42	GeneProduct	ncbigene:12540
Wasl	GeneProduct	ncbigene:73178
Was	GeneProduct	ncbigene:22376
Sra1	GeneProduct	ncbigene:24068

References

G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia