G13 signaling pathway

Anita Chow; WikiPathways Maintenance bot; Thomas Kelder; Christine Chichester; Kristina Hanspers; Egon Willighagen; Eric Weitz

G13 signaling pathway (WP298)

Mus musculus

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: Wikipedia

Authors

Anita Chow , Thomas Kelder , Christine Chichester , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Cited In

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway via Galpha12/Galpha13 family

Participants

Label	Type	Compact URI	Comment
Rtkn	GeneProduct	ncbigene:20166
Pkn1	GeneProduct	ncbigene:320795
Cfl2	GeneProduct	ncbigene:12632
Rhpn2	GeneProduct	ncbigene:52428
Rhoa	GeneProduct	ncbigene:11848
Pfn1	GeneProduct	ncbigene:18643
Arhgef1	GeneProduct	ncbigene:16801
Sra1	GeneProduct	ncbigene:24068
Gna13	GeneProduct	ncbigene:14674
Iqgap2	GeneProduct	ncbigene:544963
Iqgap1	GeneProduct	ncbigene:29875
Pik3cd	GeneProduct	ncbigene:18707	P42338
Arhgdib	GeneProduct	ncbigene:11857
Pik3cb	GeneProduct	ncbigene:74769
Sh3rf1	GeneProduct	ncbigene:59009	Posh
Limk1	GeneProduct	ncbigene:16885
Mybph	GeneProduct	ncbigene:53311
Rac1	GeneProduct	ncbigene:19353
Tnk2	GeneProduct	ncbigene:51789	S33596
Pak3	GeneProduct	ncbigene:18481
Pip4k2a	GeneProduct	ncbigene:18718
Mapk10	GeneProduct	ncbigene:26414
Calm1	GeneProduct	ncbigene:12313
Wasl	GeneProduct	ncbigene:73178
Pik3r2	GeneProduct	ncbigene:18709
Ppp1cb	GeneProduct	ncbigene:19046
Was	GeneProduct	ncbigene:22376
Map3k4	GeneProduct	ncbigene:26407
Myl1	GeneProduct	ncbigene:17901
Cit	GeneProduct	ncbigene:12704
Arhgdig	GeneProduct	ncbigene:14570
Rock1	GeneProduct	ncbigene:19877	S69211
Diap1	GeneProduct	ncbigene:13367
Pik3ca	GeneProduct	ncbigene:18706
Cdc42	GeneProduct	ncbigene:12540
Rps6kb1	GeneProduct	ncbigene:72508	A41687
Rock2	GeneProduct	ncbigene:19878	BAA31594
Cfl1	GeneProduct	ncbigene:12631

References

G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia