Aryl hydrocarbon receptor pathway (WP2586)

Homo sapiens

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Cited In

• 10.1021/acs.jproteome.7b00501.
• Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease (2022).
• WikiPathways: connecting communities (2021).

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References

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2. Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin. Nebert DW, Petersen DD, Puga A. Pharmacogenetics. 1991 Nov;1(2):68–78. PubMed Europe PMC Scholia
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7. The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction. Quattrochi LC, Vu T, Tukey RH. J Biol Chem. 1994 Mar 4;269(9):6949–54. PubMed Europe PMC Scholia
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10. Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway. Enan E, Matsumura F. Biochem Pharmacol. 1996 Nov 22;52(10):1599–612. PubMed Europe PMC Scholia
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12. Identification of cdk2 binding sites on the p27Kip1 cyclin-dependent kinase inhibitor. Kwon TK, Nordin AA. Oncogene. 1998 Feb 12;16(6):755–62. PubMed Europe PMC Scholia
13. Specificity within the EGF family/ErbB receptor family signaling network. Riese DJ 2nd, Stern DF. Bioessays. 1998 Jan;20(1):41–8. PubMed Europe PMC Scholia
14. Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, et al. Biochem Biophys Res Commun. 1998 Jul 30;248(3):789–94. PubMed Europe PMC Scholia
15. A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle. Ge NL, Elferink CJ. J Biol Chem. 1998 Aug 28;273(35):22708–13. PubMed Europe PMC Scholia
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18. Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor. Kazlauskas A, Poellinger L, Pongratz I. J Biol Chem. 1999 May 7;274(19):13519–24. PubMed Europe PMC Scholia
19. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Nguyen TA, Hoivik D, Lee JE, Safe S. Arch Biochem Biophys. 1999 Jul 15;367(2):250–7. PubMed Europe PMC Scholia
20. p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Kolluri SK, Weiss C, Koff A, Göttlicher M. Genes Dev. 1999 Jul 1;13(13):1742–53. PubMed Europe PMC Scholia
21. The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Klinge CM, Kaur K, Swanson HI. Arch Biochem Biophys. 2000 Jan 1;373(1):163–74. PubMed Europe PMC Scholia
22. Epstein-Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigen. Kashuba E, Kashuba V, Pokrovskaja K, Klein G, Szekely L. Oncogene. 2000 Mar 30;19(14):1801–6. PubMed Europe PMC Scholia
23. Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein. The role of hsp90. Bell DR, Poland A. J Biol Chem. 2000 Nov 17;275(46):36407–14. PubMed Europe PMC Scholia
24. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Trombino AF, Near RI, Matulka RA, Yang S, Hafer LJ, Toselli PA, et al. Breast Cancer Res Treat. 2000 Sep;63(2):117–31. PubMed Europe PMC Scholia
25. The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells. Kim DW, Gazourian L, Quadri SA, Romieu-Mourez R, Sherr DH, Sonenshein GE. Oncogene. 2000 Nov 16;19(48):5498–506. PubMed Europe PMC Scholia
26. Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein. Elferink CJ, Ge NL, Levine A. Mol Pharmacol. 2001 Apr;59(4):664–73. PubMed Europe PMC Scholia
27. Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. Ke S, Rabson AB, Germino JF, Gallo MA, Tian Y. J Biol Chem. 2001 Oct 26;276(43):39638–44. PubMed Europe PMC Scholia
28. Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K. Drug Metab Dispos. 2001 Sep;29(9):1176–82. PubMed Europe PMC Scholia
29. Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs). Billiard SM, Hahn ME, Franks DG, Peterson RE, Bols NC, Hodson PV. Comp Biochem Physiol B Biochem Mol Biol. 2002 Sep;133(1):55–68. PubMed Europe PMC Scholia
30. TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident. Landi MT, Bertazzi PA, Baccarelli A, Consonni D, Masten S, Lucier G, et al. Carcinogenesis. 2003 Apr;24(4):673–80. PubMed Europe PMC Scholia
31. Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block. Gottifredi V, McKinney K, Poyurovsky MV, Prives C. J Biol Chem. 2004 Feb 13;279(7):5802–10. PubMed Europe PMC Scholia
32. The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. Hollingshead BD, Petrulis JR, Perdew GH. J Biol Chem. 2004 Oct 29;279(44):45652–61. PubMed Europe PMC Scholia
33. Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. Miao W, Hu L, Scrivens PJ, Batist G. J Biol Chem. 2005 May 27;280(21):20340–8. PubMed Europe PMC Scholia
34. ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. Beischlag TV, Perdew GH. J Biol Chem. 2005 Jun 3;280(22):21607–11. PubMed Europe PMC Scholia
35. Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene. N’Diaye M, Le Ferrec E, Lagadic-Gossmann D, Corre S, Gilot D, Lecureur V, et al. J Biol Chem. 2006 Jul 21;281(29):19906–15. PubMed Europe PMC Scholia
36. Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expression. Singh NP, Nagarkatti M, Nagarkatti PS. Mol Pharmacol. 2007 Jan;71(1):145–57. PubMed Europe PMC Scholia
37. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, et al. Mol Cell Biol. 2007 Oct;27(20):7188–97. PubMed Europe PMC Scholia
38. Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages. Cheon H, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, et al. Exp Mol Med. 2007 Aug 31;39(4):524–34. PubMed Europe PMC Scholia
39. Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. Monteiro P, Gilot D, Le Ferrec E, Rauch C, Lagadic-Gossmann D, Fardel O. Mol Pharmacol. 2008 Mar;73(3):769–77. PubMed Europe PMC Scholia
40. Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression. Umannová L, Machala M, Topinka J, Nováková Z, Milcová A, Kozubík A, et al. Mutat Res. 2008 Apr 2;640(1–2):162–9. PubMed Europe PMC Scholia
41. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Kimura A, Naka T, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9721–6. PubMed Europe PMC Scholia
42. Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor. Minami K, Nakajima M, Fujiki Y, Katoh M, Gonzalez FJ, Yokoi T. J Toxicol Sci. 2008 Oct;33(4):405–13. PubMed Europe PMC Scholia
43. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. Kekatpure VD, Dannenberg AJ, Subbaramaiah K. J Biol Chem. 2009 Mar 20;284(12):7436–45. PubMed Europe PMC Scholia
44. Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. Chang KY, Shen MR, Lee MY, Wang WL, Su WC, Chang WC, et al. J Biol Chem. 2009 Apr 10;284(15):9908–16. PubMed Europe PMC Scholia
45. EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes. Sutter CH, Yin H, Li Y, Mammen JS, Bodreddigari S, Stevens G, et al. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4266–71. PubMed Europe PMC Scholia
46. The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability. Vargiolu M, Fusco D, Kurelac I, Dirnberger D, Baumeister R, Morra I, et al. J Clin Endocrinol Metab. 2009 Jul;94(7):2571–8. PubMed Europe PMC Scholia
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48. Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters. Ahmed S, Valen E, Sandelin A, Matthews J. Toxicol Sci. 2009 Oct;111(2):254–66. PubMed Europe PMC Scholia
49. Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma. Roman AC, Carvajal-Gonzalez JM, Rico-Leo EM, Fernandez-Salguero PM. J Biol Chem. 2009 Sep 11;284(37):25135–48. PubMed Europe PMC Scholia
50. Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G126-35. PubMed Europe PMC Scholia
51. Ligand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligand-binding domain. Soshilov A, Denison MS. J Biol Chem. 2011 Oct 7;286(40):35275–82. PubMed Europe PMC Scholia
52. Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway. Chahal HS, Trivellin G, Leontiou CA, Alband N, Fowkes RC, Tahir A, et al. J Clin Endocrinol Metab. 2012 Aug;97(8):E1411-20. PubMed Europe PMC Scholia
53. High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Lo R, Matthews J. Toxicol Sci. 2012 Dec;130(2):349–61. PubMed Europe PMC Scholia
54. The tumor suppressor Kruppel-like factor 6 is a novel aryl hydrocarbon receptor DNA binding partner. Wilson SR, Joshi AD, Elferink CJ. J Pharmacol Exp Ther. 2013 Jun;345(3):419–29. PubMed Europe PMC Scholia