Integrated breast cancer pathway (WP1984)

Homo sapiens

This pathway incorporates the most important proteins for breast cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in breast cancer. These proteins were then used to determine the most important pathways involved in breast cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for breast cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1984 CPTAC Assay Portal]

Authors

Sara Ibrahim , Martijn Van Iersel , Pragat11 , Daniela Digles , Egon Willighagen , Kristina Hanspers , Jakechen , Zahra Roudbari , Tdavid88 , Denise Slenter , Alex Pico , Marvin Martens , Friederike Ehrhart , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

breast cancer

Pathway Ontology

cancer pathway breast cancer pathway

Participants

Label Type Compact URI Comment
Flutamide Metabolite pubchem.compound:3397
Lithium Chloride Metabolite pubchem.compound:433294
Dihydrotestosterone Metabolite hmdb:HMDB0002961
Hydroxyurea Metabolite pubchem.compound:3657
Penicillin G Metabolite chemspider:5693
Ampicillin Metabolite pubchem.compound:6249
Raloxifene Metabolite chemspider:4859
Cycloheximide Metabolite pubchem.compound:6197
Plicamycin Metabolite pubchem.compound:457831
Anastrozole Metabolite chemspider:2102
Hydrocortisone Metabolite wikidata:Q26981430
Testosterone Metabolite chemspider:5791
Donepezil Metabolite pubchem.compound:3152
Letrozole Metabolite chemspider:3765
Dexamethasone Metabolite pubchem.compound:5743
Tamoxifen Metabolite pubchem.compound:2733526
Nocodazole Metabolite pubchem.compound:4122
Corticosterone Metabolite pubchem.compound:5753
Fulvestrant Metabolite pubchem.compound:104741
Tetradecanoylphorbol Acetate Metabolite chebi:37537
Methyl Methanesulfonate Metabolite pubchem.compound:4156
Mitomycin Metabolite chebi:25357
Paclitaxel Metabolite chemspider:10368587
Fluoxymesterone Metabolite chemspider:6205
Lapatnib Metabolite pubchem.compound:208908
Bleomycin Metabolite pubchem.compound:456190
Estradiol Metabolite pubchem.compound:5757
P85A GeneProduct ensembl:ENSG00000125450
PLK3 GeneProduct ensembl:ENSG00000173846
RPP38 GeneProduct ensembl:ENSG00000152464
CDH1 GeneProduct ensembl:ENSG00000039068
E2F1 GeneProduct ncbigene:1869
CDC25A GeneProduct ncbigene:993
GRN GeneProduct ensembl:ENSG00000030582
RASGRP3 GeneProduct ensembl:ENSG00000152689
CERK GeneProduct ncbigene:64781
FADD GeneProduct ensembl:ENSG00000168040
ERAL1 GeneProduct ensembl:ENSG00000132591
DHT GeneProduct ensembl:ENSG00000181192
HDAC1/HDAC2 GeneProduct ensembl:ENSG00000116478
MAPKs GeneProduct ncbigene:5594
TSC1 GeneProduct ensembl:ENSG00000165699
CASP8 GeneProduct ensembl:ENSG00000064012
CASP9 GeneProduct ensembl:ENSG00000132906
IMPA1 GeneProduct ensembl:ENSG00000133731
RAP1A GeneProduct ensembl:ENSG00000116473
GDI GeneProduct ncbigene:2664
RHO GeneProduct ensembl:ENSG00000163914
ITPKC GeneProduct ensembl:ENSG00000086544
KRAS GeneProduct ensembl:ENSG00000133703
P38 GeneProduct ncbigene:84640
CSNK1D GeneProduct ensembl:ENSG00000141551
CASP3 GeneProduct ensembl:ENSG00000164305
CREB GeneProduct ensembl:ENSG00000118260
IRS1 GeneProduct ensembl:ENSG00000169047
CBP GeneProduct ensembl:ENSG00000005810
BARD1 GeneProduct ensembl:ENSG00000138376
NCOA3 GeneProduct ensembl:ENSG00000124151
NCOA2 GeneProduct ensembl:ENSG00000124151
ESR1 GeneProduct ensembl:ENSG00000091831
RHO GeneProduct ncbigene:6010
BRCA2 GeneProduct ensembl:ENSG00000139618
SMEK2 GeneProduct ensembl:ENSG00000275052
FOXO1 GeneProduct ensembl:ENSG00000150907
ABL1 GeneProduct ensembl:ENSG00000097007
GCR GeneProduct ensembl:ENSG00000113161
STK11 GeneProduct ensembl:ENSG00000118046
TSC2 GeneProduct ensembl:ENSG00000103197
TFPI GeneProduct ensembl:ENSG00000003436
XRCC3 GeneProduct ensembl:ENSG00000126215
AHR GeneProduct ensembl:ENSG00000106546
EP300 GeneProduct ensembl:ENSG00000100393
ANXA1 GeneProduct ensembl:ENSG00000135046
SP1 GeneProduct ensembl:ENSG00000185591
RASGEF1A GeneProduct ncbigene:221002
BARD1 GeneProduct ncbigene:580
BAX GeneProduct ensembl:ENSG00000087088
SMEK1 GeneProduct ensembl:ENSG00000100796
PHB GeneProduct ensembl:ENSG00000167085
JUN GeneProduct ensembl:ENSG00000177606
PLK3CA GeneProduct ncbigene:1263
BMPR1A GeneProduct ensembl:ENSG00000107779
VEGFA GeneProduct ensembl:ENSG00000112715
P13K GeneProduct ensembl:ENSG00000229882
AURKA GeneProduct ensembl:ENSG00000087586
GADD45A GeneProduct ensembl:ENSG00000116717
MTOR GeneProduct ensembl:ENSG00000198793
RAD54L GeneProduct ensembl:ENSG00000085999
DAG1 GeneProduct ensembl:ENSG00000173402
CDC42 GeneProduct ensembl:ENSG00000070831
ERK GeneProduct ncbigene:64781
CDK7 GeneProduct ncbigene:1022
CYP19A1 GeneProduct ensembl:ENSG00000137869
RALGAPA1 GeneProduct ensembl:ENSG00000174373
SMAD1 Protein uniprot:Q15797
NOXA1 Protein uniprot:Q86UR1
ATR Protein uniprot:Q13535
IKKA Protein uniprot:O15111
AR Protein uniprot:Q9UNE0
PR Protein uniprot:P12270
WEE1 Protein uniprot:P30291
MYT1 Protein uniprot:Q01538
TAB1 Protein uniprot:Q15750
MMP1 Protein uniprot:P03956
PPAR Protein ncbigene:8061
UBE2F Protein uniprot:Q969M7
SMCA4 Protein uniprot:P51532
BMPR2 Protein uniprot:Q13873
RRAS Protein uniprot:P10301
SMAD7 Protein uniprot:O15105
BAD Protein uniprot:Q92934
ZN655 Protein uniprot:Q8N720 AKA C9JNK1
HIPK2 Protein uniprot:Q9H2X6
TAK1L Protein uniprot:P57077
CHK2 Protein uniprot:O96017 Phosphorylated
TGFR1 Protein uniprot:P36897
PLK1 Protein uniprot:P53350
MAP3K13 Protein uniprot:O43283 AKA P65
MDM2 Protein uniprot:Q00987
RAC1 Protein uniprot:P63000
JUN Protein ncbigene:3725
ATM Protein uniprot:Q13315
ABC3G Protein uniprot:Q9HC16
MSH6 Protein uniprot:P52701
SMAD6 Protein uniprot:O43541
BLM Protein uniprot:P54132
RAD51 Protein uniprot:Q06609
MRE11 Protein uniprot:P49959
BCL2 Protein uniprot:P10415
PKCB1 Protein uniprot:Q9ULU4
PTEN Protein uniprot:P60484
SMAD2 Protein uniprot:Q15796
BRCA1 Protein uniprot:P38398
TSC1 Protein uniprot:Q92574
UBIM Protein uniprot:P35544
TGFR2 Protein uniprot:P37173
RAD50 Protein uniprot:Q92878
GR Protein uniprot:P01833
MYC Protein ncbigene:4609
CTNB1 Protein uniprot:P35222
GSK3A Protein uniprot:P49840
P53 Protein uniprot:P04637
ER Protein uniprot:P16591
MSH2 Protein uniprot:P43246
JKIP1 Protein uniprot:Q96N16
MPIP1 Protein uniprot:P30304
P85 Protein uniprot:O00459
FLIP1 Protein uniprot:Q7Z7B0
UBP15 Protein uniprot:Q9Y4E8
CDK2 Protein uniprot:P24941
ATF1 Protein uniprot:P18846
AKT1 Protein uniprot:P31749
MAX Protein uniprot:P61244
ALKB1 Protein uniprot:Q13686
E2F1 Protein uniprot:Q01094
SELK Protein uniprot:Q9Y6D0
PPRB/RB Protein uniprot:P06400
HDAC1 Protein uniprot:Q13547
P13 Protein uniprot:Q9UHV8
RHEB Protein uniprot:Q15382
MPIP2 Protein uniprot:P30305
ANDR Protein uniprot:P10275
NAB1 Protein uniprot:Q13506
NF1 Protein uniprot:P21359
DCAKD Protein uniprot:Q8WVC6
SMAD3 Protein uniprot:Q13485
fra-1 Protein ncbigene:8061
SMAD4 Protein uniprot:Q13485
SMAD4 Protein uniprot:Q15796
AQP73 Protein uniprot:A6NL99
UBP21 Protein uniprot:Q9UK80
FADD Protein uniprot:Q13158
JAK1 Protein uniprot:P23458
FOSL2 Protein uniprot:P15408 AKA B3KP27
STAT1 Protein uniprot:P42224
Q8NBS1 Protein uniprot:Q8NBS1
BID Protein uniprot:P55957
EGFR Protein uniprot:P00533
NFKB1 Protein uniprot:P19838
SIRT1 Protein uniprot:Q96EB6
BACH1 Protein uniprot:O14867
CHK1 Protein uniprot:O14757
ODC1 Protein ncbigene:4953
TRADD Protein uniprot:Q15628
ZMIZ1 Protein uniprot:Q9ULJ6
BRAF Protein uniprot:P15056
RALA Protein uniprot:P11233
PML Protein uniprot:P29590
UBP16 Protein uniprot:Q9Y5T5
CIP1 Protein uniprot:Q9NPC3
MYC Protein uniprot:P01106
CCND1 Protein uniprot:P24385
RAF Protein uniprot:P10398
CDK4 Protein uniprot:P11802
CERK1 Protein uniprot:Q8TCT0
BAK Protein uniprot:Q16611
PIAS1 Protein uniprot:O75925
IPKA Protein uniprot:P61925
PAK1 Protein uniprot:Q13153

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