FAS pathway and stress induction of HSP regulation (WP1019)

Bos taurus

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].

Authors

Thomas Kelder , Kristina Hanspers , Christine Chichester , Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

stress response pathway FasL mediated signaling pathway

Participants

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Ceramide Metabolite cas:104404-17-3
SPTAN1 GeneProduct ensembl:ENSBTAG00000015327 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6709
IL1A GeneProduct ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
FAF1 GeneProduct ensembl:ENSBTAG00000014482 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11124
CASP7 GeneProduct ensembl:ENSBTAG00000006615 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:840
HSPB1 GeneProduct ensembl:ENSBTAG00000011969 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315
RIPK2 GeneProduct ensembl:ENSBTAG00000015271 receptor (TNFRSF)-interacting serine-threonine kinase 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8767
DFFB GeneProduct ensembl:ENSBTAG00000020015 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1677
PAK1 GeneProduct ensembl:ENSBTAG00000010191 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
APAF1 GeneProduct ensembl:ENSBTAG00000021661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317
DAXX GeneProduct ensembl:ENSBTAG00000016830 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1616
MAPKAPK2 GeneProduct ensembl:ENSBTAG00000038107 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
CASP8 GeneProduct ensembl:ENSBTAG00000015718 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841
PARP1 GeneProduct ensembl:ENSBTAG00000000837 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:142
DFFA GeneProduct ensembl:ENSBTAG00000013535 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1676
ARHGDIB GeneProduct ensembl:ENSBTAG00000006039 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:397
CYCS GeneProduct ensembl:ENSBTAG00000022613 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54205
FASLG GeneProduct ensembl:ENSBTAG00000032808 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:356
FADD GeneProduct ensembl:ENSBTAG00000018274 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772
RB1 GeneProduct ensembl:ENSBTAG00000006640 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
ACTA1 GeneProduct ensembl:ENSBTAG00000046332 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
MAPKAPK3 GeneProduct ensembl:ENSBTAG00000016532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7867
MAP2K4 GeneProduct ensembl:ENSBTAG00000012103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
CASP6 GeneProduct ensembl:ENSBTAG00000012537 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:839
PAK2 GeneProduct ensembl:ENSBTAG00000047856 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062
MAP3K7 GeneProduct ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
LMNB1 GeneProduct ensembl:ENSBTAG00000002882 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4001
LMNB2 GeneProduct ensembl:ENSBTAG00000013624 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84823
CASP9 GeneProduct ensembl:ENSBTAG00000002472 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:842
FLIP GeneProduct ensembl:ENSBTAG00000010998 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8837
BCL2 GeneProduct ensembl:ENSBTAG00000019302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
MAP3K1 GeneProduct ensembl:ENSBTAG00000013790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
CASP3 GeneProduct ensembl:ENSBTAG00000015874 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
PRKDC GeneProduct ensembl:ENSBTAG00000017019 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591
LMNA GeneProduct ensembl:ENSBTAG00000017574 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4000
NFX1 GeneProduct ensembl:ENSBTAG00000012385 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4799
FAS GeneProduct ensembl:ENSBTAG00000010785 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:355
ACTB GeneProduct ensembl:ENSBTAG00000026199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
ACTG1 GeneProduct ensembl:ENSBTAG00000006189 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia
  2. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, et al. BMC Cancer. 2008 Sep 21;8:266. PubMed Europe PMC Scholia