Suppression of HMGB1-mediated inflammation by THBD (WP4479)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
THBD inhibition of HMGB1 mediated pro-inflammatory pathway via proteolytic cleavage of HMGB1.

Authors

Laurent Winckers , Eric Weitz , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
IkKA GeneProduct ncbigene:1147
IkKB GeneProduct ncbigene:3551
IkKG GeneProduct ncbigene:8517
IkBA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
THBD GeneProduct ncbigene:7056
HMGB1 GeneProduct ncbigene:3146
RAGE GeneProduct ncbigene:177
NFKB1 GeneProduct ncbigene:4790

References

  1. Introduction to NF-kappaB: players, pathways, perspectives. Gilmore TD. Oncogene. 2006 Oct 30;25(51):6680–4. PubMed Europe PMC Scholia
  2. The role of thrombomodulin lectin-like domain in inflammation. Li YH, Kuo CH, Shi GY, Wu HL. J Biomed Sci. 2012 Mar 27;19(1):34. PubMed Europe PMC Scholia