Suppression of HMGB1-mediated inflammation by THBD (WP4479)

Homo sapiens

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THBD inhibition of HMGB1 mediated pro-inflammatory pathway via proteolytic cleavage of HMGB1.

Authors

Laurent Winckers , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
IkKA GeneProduct ncbigene:1147
IkKB GeneProduct ncbigene:3551
IkKG GeneProduct ncbigene:8517
IkBA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
THBD GeneProduct ncbigene:7056
HMGB1 GeneProduct ncbigene:3146
RAGE GeneProduct ncbigene:177
NFKB1 GeneProduct ncbigene:4790
HMGB1 GeneProduct ncbigene:3146
THBD GeneProduct ncbigene:7056
HMGB1 GeneProduct ncbigene:3146
IkBA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790

References

  1. Introduction to NF-kappaB: players, pathways, perspectives. Gilmore TD. Oncogene. 2006 Oct 30;25(51):6680–4. PubMed Europe PMC Scholia
  2. The role of thrombomodulin lectin-like domain in inflammation. Li YH, Kuo CH, Shi GY, Wu HL. J Biomed Sci. 2012 Mar 27;19(1):34. PubMed Europe PMC Scholia