MAPK signaling pathway (WP1114)

Canis familiaris

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Authors

Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway

Participants

Label Type Compact URI Comment
LPS Metabolite chebi:16412
IP3 Metabolite chebi:16595
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite hmdb:HMDB0000058
DAG Metabolite chebi:18035
TRAF6 GeneProduct ensembl:ENSCAFG00000006813 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7189
MEF2C GeneProduct ensembl:ENSCAFG00000008302 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4208
SRF GeneProduct ensembl:ENSCAFG00000001829 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6722
RPS6KA3 GeneProduct ensembl:ENSCAFG00000013171 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6197
MAP2K3 GeneProduct ensembl:ENSCAFG00000018530 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5606
ELK4 GeneProduct ensembl:ENSCAFG00000010144 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158711
RAP1A GeneProduct ensembl:ENSCAFG00000013686 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5906
CRK GeneProduct ensembl:ENSCAFG00000019157 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1398
IL1A GeneProduct ensembl:ENSCAFG00000007245 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3552
PDGFB GeneProduct ensembl:ENSCAFG00000001356 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5155
AKT3 GeneProduct ensembl:ENSCAFG00000015806 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10000
ECSIT GeneProduct ensembl:ENSCAFG00000017334 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51295
MAP3K13 GeneProduct ensembl:ENSCAFG00000013230 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9175
RASGRP4 GeneProduct ensembl:ENSCAFG00000005909 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:115727
MAP3K7 GeneProduct ensembl:ENSCAFG00000003123 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6885
MAPK9 GeneProduct ensembl:ENSCAFG00000000395 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5601
GRB2 GeneProduct ensembl:ENSCAFG00000030297 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2885
MKNK1 GeneProduct ensembl:ENSCAFG00000004205 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8569
DUSP1 GeneProduct ensembl:ENSCAFG00000029826 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1843
STMN1 GeneProduct ensembl:ENSCAFG00000029191 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3925
ELK1 GeneProduct ensembl:ENSCAFG00000015178 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2002
EGFR GeneProduct ensembl:ENSCAFG00000003465 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1956
PPP3CB GeneProduct ensembl:ENSCAFG00000014818 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5532
PPP3CC GeneProduct ensembl:ENSCAFG00000009390 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5533
MAP4K1 GeneProduct ensembl:ENSCAFG00000005874 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11184
NFATC1 GeneProduct ensembl:ENSCAFG00000000011 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4772
ARRB2 GeneProduct ensembl:ENSCAFG00000015905 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:409
MAPT GeneProduct ensembl:ENSCAFG00000013670 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4137
RASGRP1 GeneProduct ensembl:ENSCAFG00000008674 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10125
IKBKG GeneProduct ensembl:ENSCAFG00000019605 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8517
BDNF GeneProduct ensembl:ENSCAFG00000010207 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:627
DAXX GeneProduct ensembl:ENSCAFG00000000981 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1616
MAPK10 GeneProduct ensembl:ENSCAFG00000009396 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5602
TNF GeneProduct ensembl:ENSCAFG00000000517 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7124
MOS GeneProduct ensembl:ENSCAFG00000007046 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4342
STK4 GeneProduct ensembl:ENSCAFG00000009615 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000101109
MAPK14 GeneProduct ensembl:ENSCAFG00000001378 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1432
IKBKB GeneProduct ensembl:ENSCAFG00000005526 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3551
ARRB1 GeneProduct ensembl:ENSCAFG00000005415 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:408
LRRK2 GeneProduct ensembl:ENSCAFG00000009926 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000188906
CASP3 GeneProduct ensembl:ENSCAFG00000007750 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:836
FLNA GeneProduct ensembl:ENSCAFG00000019521 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2316
PRKACA GeneProduct ensembl:ENSCAFG00000016488 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5566
MAPKAPK2 GeneProduct ensembl:ENSCAFG00000011432 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9261
TNFRSF1A GeneProduct ensembl:ENSCAFG00000015197 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000067182
MAP3K14 GeneProduct ensembl:ENSCAFG00000013774 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000006062
HSPB1 GeneProduct ensembl:ENSCAFG00000013544 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3315
MAP3K20 GeneProduct ensembl:ENSCAFG00000013140 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51776
GNA12 GeneProduct ensembl:ENSCAFG00000029596 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2768
TGFB1 GeneProduct ensembl:ENSCAFG00000005014 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7040
MAP3K1 GeneProduct ensembl:ENSCAFG00000006917 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4214
MAP3K2 GeneProduct ensembl:ENSCAFG00000004528 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10746
MAX GeneProduct ensembl:ENSCAFG00000016212 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4149
DUSP10 GeneProduct ensembl:ENSCAFG00000013641 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11221
RASGRF2 GeneProduct ensembl:ENSCAFG00000008744 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5924
MAP4K4 GeneProduct ensembl:ENSCAFG00000002162 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9448
PDGFRB GeneProduct ensembl:ENSCAFG00000018214 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5159
TAB1 GeneProduct ensembl:ENSCAFG00000001332 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10454
MAP3K4 GeneProduct ensembl:ENSCAFG00000000760 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4216
GADD45A GeneProduct ensembl:ENSCAFG00000029474 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1647
MAP2K5 GeneProduct ensembl:ENSCAFG00000017454 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5607
CDC25B GeneProduct ensembl:ENSCAFG00000006175 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:994
IL1R1 GeneProduct ensembl:ENSCAFG00000002147 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3554
RAC2 GeneProduct ensembl:ENSCAFG00000001508 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5880
PRKCD GeneProduct ensembl:ENSCAFG00000008689 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5580
PPP5C GeneProduct ensembl:ENSCAFG00000004313 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5536
MAP2K1 GeneProduct ensembl:ENSCAFG00000017298 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5604
RAC1 GeneProduct ensembl:ENSCAFG00000015716 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5879
PTPN7 GeneProduct ensembl:ENSCAFG00000010591 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5778
IL1R2 GeneProduct ensembl:ENSCAFG00000002152 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7850
TAB2 GeneProduct ensembl:ENSCAFG00000000373 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23118
TGFBR1 GeneProduct ensembl:ENSCAFG00000002528 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7046
MAPK1 GeneProduct ensembl:ENSCAFG00000015421 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5594
PTPRR GeneProduct ensembl:ENSCAFG00000023742 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5801
PTPN5 GeneProduct ensembl:ENSCAFG00000009391 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:84867
PLA2G4D GeneProduct ensembl:ENSCAFG00000024815 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000159337
BRAF GeneProduct ensembl:ENSCAFG00000003907 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:673
NTRK1 GeneProduct ensembl:ENSCAFG00000016528 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4914
ATF2 GeneProduct ensembl:ENSCAFG00000013332 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1386
MAP2K4 GeneProduct ensembl:ENSCAFG00000017851 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6416
FOS GeneProduct ensembl:ENSCAFG00000017040 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2353
PRKCG GeneProduct ensembl:ENSCAFG00000002713 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5582
MYC GeneProduct ensembl:ENSCAFG00000001086 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4609
SOS2 GeneProduct ensembl:ENSCAFG00000014275 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6655
TGFB2 GeneProduct ensembl:ENSCAFG00000010815 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7042
MAPK7 GeneProduct ensembl:ENSCAFG00000018202 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5598
DUSP4 GeneProduct ensembl:ENSCAFG00000030240 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1846
CACNG3 GeneProduct ensembl:ENSCAFG00000017571 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = H:CACNG3
HSPA8 GeneProduct ensembl:ENSCAFG00000001886 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3312
MAPK12 GeneProduct ensembl:ENSCAFG00000000685 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6300
MAPK8IP1 GeneProduct ensembl:ENSCAFG00000009363 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000121653
PPM1A GeneProduct ensembl:ENSCAFG00000015603 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5494
IL1B GeneProduct ensembl:ENSCAFG00000007249 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3553
TRAF2 GeneProduct ensembl:ENSCAFG00000019541 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7186
MAPK13 GeneProduct ensembl:ENSCAFG00000001382 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5603
TAOK1 GeneProduct ensembl:ENSCAFG00000018898 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57551
MAP2K6 GeneProduct ensembl:ENSCAFG00000010758 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5608
DUSP8 GeneProduct ensembl:ENSCAFG00000010009 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000184545
AKT2 GeneProduct ensembl:ENSCAFG00000005388 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:208
MAPKAPK5 GeneProduct ensembl:ENSCAFG00000008745 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8550
RASA2 GeneProduct ensembl:ENSCAFG00000007674 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5922
DUSP7 GeneProduct ensembl:ENSCAFG00000032027 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1849
FGFR1 GeneProduct ensembl:ENSCAFG00000005970 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2260
TGFB3 GeneProduct ensembl:ENSCAFG00000017101 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7043
PPP3CA GeneProduct ensembl:ENSCAFG00000010644 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5530
EGF GeneProduct ensembl:ENSCAFG00000011532 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1950
DDIT3 GeneProduct ensembl:ENSCAFG00000030112 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1649
MAP3K6 GeneProduct ensembl:ENSCAFG00000012144 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9064
MAP3K8 GeneProduct ensembl:ENSCAFG00000003980 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1326
NGF GeneProduct ensembl:ENSCAFG00000009739 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000134259
CRKL GeneProduct ensembl:ENSCAFG00000015188 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1399
TAOK2 GeneProduct ensembl:ENSCAFG00000017039 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9344
MAPK3 GeneProduct ensembl:ENSCAFG00000018974 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5595
MAPK8 GeneProduct ensembl:ENSCAFG00000006551 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5599
NR4A1 GeneProduct ensembl:ENSCAFG00000007338 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3164
PRKCA GeneProduct ensembl:ENSCAFG00000011326 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000154229
ATF4 GeneProduct ensembl:ENSCAFG00000001324 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:468
NTF4 GeneProduct ensembl:ENSCAFG00000003838 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000225950
PDGFA GeneProduct ensembl:ENSCAFG00000011193 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000197461
NTRK2 GeneProduct ensembl:ENSCAFG00000001380 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000148053
FASLG GeneProduct ensembl:ENSCAFG00000014678 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:356
PDGFRB GeneProduct ensembl:ENSCAFG00000018214 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000113721
PPM1B GeneProduct ensembl:ENSCAFG00000002535 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5495
FGFR2 GeneProduct ensembl:ENSCAFG00000012374 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000066468
CDC42 GeneProduct ensembl:ENSCAFG00000014707 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:998
FGFR3 GeneProduct ensembl:ENSCAFG00000014993 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000068078
LAMTOR3 GeneProduct ensembl:ENSCAFG00000029975 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8649
FGFR4 GeneProduct ensembl:ENSCAFG00000016518 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000160867
JUN GeneProduct ensembl:ENSCAFG00000018897 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3725
SOS1 GeneProduct ensembl:ENSCAFG00000006340 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000115904
JUND GeneProduct ensembl:ENSCAFG00000023338 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3727
RRAS GeneProduct ensembl:ENSCAFG00000003604 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000126458
HRAS GeneProduct ensembl:ENSCAFG00000031029 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000174775
RPS6KA5 GeneProduct ensembl:ENSCAFG00000017543 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9252
MAP3K12 GeneProduct ensembl:ENSCAFG00000006918 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7786
TP53 GeneProduct ensembl:ENSCAFG00000016714 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7157
RRAS2 GeneProduct ensembl:ENSCAFG00000008396 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000133818
NFKB1 GeneProduct ensembl:ENSCAFG00000010730 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4790
GNG12 GeneProduct ensembl:ENSCAFG00000028654 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000172380
NF1 GeneProduct ensembl:ENSCAFG00000018592 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196712
RASGRP2 GeneProduct ensembl:ENSCAFG00000014309 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000068831
AKT1 GeneProduct ensembl:ENSCAFG00000018354 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:207
RASGRP3 GeneProduct ensembl:ENSCAFG00000005870 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000152689
RASGRP4 GeneProduct ensembl:ENSCAFG00000005909 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000171777
RASA1 GeneProduct ensembl:ENSCAFG00000008410 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5921
RASGRF1 GeneProduct ensembl:ENSCAFG00000014053 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000058335
NTF3 GeneProduct ensembl:ENSCAFG00000015278 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000185652
RAPGEF2 GeneProduct ensembl:ENSCAFG00000008719 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000109756
PRKACB GeneProduct ensembl:ENSCAFG00000020319 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000142875
STK3 GeneProduct ensembl:ENSCAFG00000000484 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6788
DUSP3 GeneProduct ensembl:ENSCAFG00000028570 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000108861
MAP4K3 GeneProduct ensembl:ENSCAFG00000006426 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8491
CHUK GeneProduct ensembl:ENSCAFG00000009588 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000213341
TGFBR2 GeneProduct ensembl:ENSCAFG00000005449 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7048
NFKB2 GeneProduct ensembl:ENSCAFG00000010155 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000077150
MAP4K2 GeneProduct ensembl:ENSCAFG00000014216 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000168067
RELA GeneProduct ensembl:ENSCAFG00000013334 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000173039
MAP2K7 GeneProduct ensembl:ENSCAFG00000031522 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5609
RELB GeneProduct ensembl:ENSCAFG00000004597 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000104856
DUSP9 GeneProduct ensembl:ENSCAFG00000019241 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000130829
NLK GeneProduct ensembl:ENSCAFG00000018650 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51701
DUSP2 GeneProduct ensembl:ENSCAFG00000023317 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158050
DUSP16 GeneProduct ensembl:ENSCAFG00000013274 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000111266
FAS GeneProduct ensembl:ENSCAFG00000015712 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:355
MKNK2 GeneProduct ensembl:ENSCAFG00000019429 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000099875
PLA2G4A GeneProduct ensembl:ENSCAFG00000013778 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000116711
NFATC3 GeneProduct ensembl:ENSCAFG00000020324 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000072736
MAP3K5 GeneProduct ensembl:ENSCAFG00000000251 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4217
MAP3K11 GeneProduct ensembl:ENSCAFG00000013415 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4296
TAOK3 GeneProduct ensembl:ENSCAFG00000009924 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000135090
DUSP6 GeneProduct ensembl:ENSCAFG00000006100 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1848
MAP2K2 GeneProduct ensembl:ENSCAFG00000019138 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5605
RPS6KA4 GeneProduct ensembl:ENSCAFG00000031793 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000162302
MAPKAPK3 GeneProduct ensembl:ENSCAFG00000010281 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000114738
MAPK8IP2 GeneProduct ensembl:ENSCAFG00000000568 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000008735
MAPK8IP3 GeneProduct ensembl:ENSCAFG00000019513 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138834
FLNB GeneProduct ensembl:ENSCAFG00000007603 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000136068
FLNC GeneProduct ensembl:ENSCAFG00000001585 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000128591
HSPA1L GeneProduct ensembl:ENSCAFG00000000639 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000204390
HSPA2 GeneProduct ensembl:ENSCAFG00000016031 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000126803
MRAS GeneProduct ensembl:ENSCAFG00000007541 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:22808
NRAS GeneProduct ensembl:ENSCAFG00000009532 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4893
KRAS GeneProduct ensembl:ENSCAFG00000011428 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3845
RAF1 GeneProduct ensembl:ENSCAFG00000004951 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5894
PLA2G4F GeneProduct ensembl:ENSCAFG00000009914 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000168907
PLA2G4B GeneProduct ensembl:ENSCAFG00000009735 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000243708
PLA2G4E GeneProduct ensembl:ENSCAFG00000024908 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000188089
CACNG2 GeneProduct ensembl:ENSCAFG00000029809 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000166862
CACNG5 GeneProduct ensembl:ENSCAFG00000031724 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000075429
CACNA2D3 GeneProduct ensembl:ENSCAFG00000008211 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000157445
CACNG8 GeneProduct ensembl:ENSCAFG00000032667 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000142408
CACNG7 GeneProduct ensembl:ENSCAFG00000002705 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000105605
CACNG6 GeneProduct ensembl:ENSCAFG00000002704 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000130433
CACNA1A GeneProduct ensembl:ENSCAFG00000016897 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000141837
CACNA1B GeneProduct ensembl:ENSCAFG00000019380 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000148408
CACNA1C GeneProduct ensembl:ENSCAFG00000016051 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000151067
CACNA1D GeneProduct ensembl:ENSCAFG00000008525 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000157388
CACNA1E GeneProduct ensembl:ENSCAFG00000013004 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000198216
CACNA1F GeneProduct ensembl:ENSCAFG00000015873 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102001
CACNA1S GeneProduct ensembl:ENSCAFG00000010884 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000081248
CACNA2D1 GeneProduct ensembl:ENSCAFG00000006339 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000153956
CACNB1 GeneProduct ensembl:ENSCAFG00000016510 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000067191
CACNB2 GeneProduct ensembl:ENSCAFG00000004474 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000165995
CACNB3 GeneProduct ensembl:ENSCAFG00000008857 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000167535
CACNB4 GeneProduct ensembl:ENSCAFG00000005773 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000182389
CACNG1 GeneProduct ensembl:ENSCAFG00000011372 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000108878
CACNA1I GeneProduct ensembl:ENSCAFG00000001314 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000100346
CACNA1H GeneProduct ensembl:ENSCAFG00000019596 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196557
CACNA1G GeneProduct ensembl:ENSCAFG00000017120 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000006283
CACNA2D2 GeneProduct ensembl:ENSCAFG00000010431 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000007402
FGF4 GeneProduct ensembl:ENSCAFG00000029983 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2249
FGF1 GeneProduct ensembl:ENSCAFG00000031965 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000113578
FGF2 GeneProduct ensembl:ENSCAFG00000003996 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138685
FGF3 GeneProduct ensembl:ENSCAFG00000010688 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000186895
FGF4 GeneProduct ensembl:ENSCAFG00000029983 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000075388
FGF5 GeneProduct ensembl:ENSCAFG00000008886 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138675
FGF6 GeneProduct ensembl:ENSCAFG00000015361 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000111241
FGF7 GeneProduct ensembl:ENSCAFG00000014923 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000140285
FGF8 GeneProduct ensembl:ENSCAFG00000009918 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000107831
FGF9 GeneProduct ensembl:ENSCAFG00000029890 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102678
FGF10 GeneProduct ensembl:ENSCAFG00000032695 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000070193
FGF11 GeneProduct ensembl:ENSCAFG00000028562 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000161958
FGF12 GeneProduct ensembl:ENSCAFG00000031187 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000114279
FGF13 GeneProduct ensembl:ENSCAFG00000032672 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000129682
FGF14 GeneProduct ensembl:ENSCAFG00000005926 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102466
FGF20 GeneProduct ensembl:ENSCAFG00000006845 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000078579
FGF21 GeneProduct ensembl:ENSCAFG00000003904 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000105550
FGF22 GeneProduct ensembl:ENSCAFG00000019707 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000070388
FGF23 GeneProduct ensembl:ENSCAFG00000015365 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000118972
FGF18 GeneProduct ensembl:ENSCAFG00000016903 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000156427
FGF17 GeneProduct ensembl:ENSCAFG00000009749 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158815
FGF16 GeneProduct ensembl:ENSCAFG00000029141 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196468
FGF19 GeneProduct ensembl:ENSCAFG00000010693 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000162344
PAK2 GeneProduct ensembl:ENSCAFG00000013067 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5062
PAK1 GeneProduct ensembl:ENSCAFG00000004956 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5058

References

  1. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Harper SJ, LoGrasso P. Cell Signal. 2001 May;13(5):299–310. PubMed Europe PMC Scholia
  2. MAP kinases. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, et al. Chem Rev. 2001 Aug;101(8):2449–76. PubMed Europe PMC Scholia
  3. Docking interactions in the mitogen-activated protein kinase cascades. Tanoue T, Nishida E. Pharmacol Ther. 2002;93(2–3):193–202. PubMed Europe PMC Scholia
  4. Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. Takeda K, Ichijo H. Genes Cells. 2002 Nov;7(11):1099–111. PubMed Europe PMC Scholia
  5. The role of mitogen-activated protein kinase pathways in Alzheimer’s disease. Zhu X, Lee H gon, Raina AK, Perry G, Smith MA. Neurosignals. 2002;11(5):270–81. PubMed Europe PMC Scholia
  6. Trk receptors: roles in neuronal signal transduction. Huang EJ, Reichardt LF. Annu Rev Biochem. 2003;72:609–42. PubMed Europe PMC Scholia
  7. Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, et al. Toxicol Lett. 2003 Aug 28;143(3):323–30. PubMed Europe PMC Scholia
  8. MAPK pathways in radiation responses. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. Oncogene. 2003 Sep 1;22(37):5885–96. PubMed Europe PMC Scholia
  9. Transcriptional regulation by the MAP kinase signaling cascades. Yang SH, Sharrocks AD, Whitmarsh AJ. Gene. 2003 Nov 27;320:3–21. PubMed Europe PMC Scholia
  10. MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta. Abell AN, Granger DA, Johnson GL. J Biol Chem. 2007 Oct 19;282(42):30476–84. PubMed Europe PMC Scholia
  11. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, et al. Cell Death Differ. 2012 Oct;19(10):1623–33. PubMed Europe PMC Scholia