MAPK signaling pathway (WP1114)
Canis familiaris
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010
Authors
Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric WeitzActivity
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Organisms
Canis familiarisCommunities
Annotations
Pathway Ontology
mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| LPS | Metabolite | chebi:16412 | |
| IP3 | Metabolite | chebi:16595 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| DAG | Metabolite | chebi:18035 | |
| TRAF6 | GeneProduct | ensembl:ENSCAFG00000006813 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7189 |
| MEF2C | GeneProduct | ensembl:ENSCAFG00000008302 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4208 |
| SRF | GeneProduct | ensembl:ENSCAFG00000001829 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6722 |
| RPS6KA3 | GeneProduct | ensembl:ENSCAFG00000013171 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6197 |
| MAP2K3 | GeneProduct | ensembl:ENSCAFG00000018530 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5606 |
| ELK4 | GeneProduct | ensembl:ENSCAFG00000010144 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158711 |
| RAP1A | GeneProduct | ensembl:ENSCAFG00000013686 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5906 |
| CRK | GeneProduct | ensembl:ENSCAFG00000019157 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1398 |
| IL1A | GeneProduct | ensembl:ENSCAFG00000007245 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3552 |
| PDGFB | GeneProduct | ensembl:ENSCAFG00000001356 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5155 |
| AKT3 | GeneProduct | ensembl:ENSCAFG00000015806 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10000 |
| ECSIT | GeneProduct | ensembl:ENSCAFG00000017334 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51295 |
| MAP3K13 | GeneProduct | ensembl:ENSCAFG00000013230 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9175 |
| RASGRP4 | GeneProduct | ensembl:ENSCAFG00000005909 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:115727 |
| MAP3K7 | GeneProduct | ensembl:ENSCAFG00000003123 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6885 |
| MAPK9 | GeneProduct | ensembl:ENSCAFG00000000395 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5601 |
| GRB2 | GeneProduct | ensembl:ENSCAFG00000030297 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2885 |
| MKNK1 | GeneProduct | ensembl:ENSCAFG00000004205 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8569 |
| DUSP1 | GeneProduct | ensembl:ENSCAFG00000029826 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1843 |
| STMN1 | GeneProduct | ensembl:ENSCAFG00000029191 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3925 |
| ELK1 | GeneProduct | ensembl:ENSCAFG00000015178 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2002 |
| EGFR | GeneProduct | ensembl:ENSCAFG00000003465 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1956 |
| PPP3CB | GeneProduct | ensembl:ENSCAFG00000014818 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5532 |
| PPP3CC | GeneProduct | ensembl:ENSCAFG00000009390 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5533 |
| MAP4K1 | GeneProduct | ensembl:ENSCAFG00000005874 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11184 |
| NFATC1 | GeneProduct | ensembl:ENSCAFG00000000011 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4772 |
| ARRB2 | GeneProduct | ensembl:ENSCAFG00000015905 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:409 |
| MAPT | GeneProduct | ensembl:ENSCAFG00000013670 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4137 |
| RASGRP1 | GeneProduct | ensembl:ENSCAFG00000008674 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10125 |
| IKBKG | GeneProduct | ensembl:ENSCAFG00000019605 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8517 |
| BDNF | GeneProduct | ensembl:ENSCAFG00000010207 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:627 |
| DAXX | GeneProduct | ensembl:ENSCAFG00000000981 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1616 |
| MAPK10 | GeneProduct | ensembl:ENSCAFG00000009396 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5602 |
| TNF | GeneProduct | ensembl:ENSCAFG00000000517 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7124 |
| MOS | GeneProduct | ensembl:ENSCAFG00000007046 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4342 |
| STK4 | GeneProduct | ensembl:ENSCAFG00000009615 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000101109 |
| MAPK14 | GeneProduct | ensembl:ENSCAFG00000001378 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1432 |
| IKBKB | GeneProduct | ensembl:ENSCAFG00000005526 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3551 |
| ARRB1 | GeneProduct | ensembl:ENSCAFG00000005415 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:408 |
| LRRK2 | GeneProduct | ensembl:ENSCAFG00000009926 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000188906 |
| CASP3 | GeneProduct | ensembl:ENSCAFG00000007750 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:836 |
| FLNA | GeneProduct | ensembl:ENSCAFG00000019521 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2316 |
| PRKACA | GeneProduct | ensembl:ENSCAFG00000016488 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5566 |
| MAPKAPK2 | GeneProduct | ensembl:ENSCAFG00000011432 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9261 |
| TNFRSF1A | GeneProduct | ensembl:ENSCAFG00000015197 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000067182 |
| MAP3K14 | GeneProduct | ensembl:ENSCAFG00000013774 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000006062 |
| HSPB1 | GeneProduct | ensembl:ENSCAFG00000013544 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3315 |
| MAP3K20 | GeneProduct | ensembl:ENSCAFG00000013140 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51776 |
| GNA12 | GeneProduct | ensembl:ENSCAFG00000029596 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2768 |
| TGFB1 | GeneProduct | ensembl:ENSCAFG00000005014 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7040 |
| MAP3K1 | GeneProduct | ensembl:ENSCAFG00000006917 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4214 |
| MAP3K2 | GeneProduct | ensembl:ENSCAFG00000004528 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10746 |
| MAX | GeneProduct | ensembl:ENSCAFG00000016212 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4149 |
| DUSP10 | GeneProduct | ensembl:ENSCAFG00000013641 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11221 |
| RASGRF2 | GeneProduct | ensembl:ENSCAFG00000008744 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5924 |
| MAP4K4 | GeneProduct | ensembl:ENSCAFG00000002162 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9448 |
| PDGFRB | GeneProduct | ensembl:ENSCAFG00000018214 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5159 |
| TAB1 | GeneProduct | ensembl:ENSCAFG00000001332 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10454 |
| MAP3K4 | GeneProduct | ensembl:ENSCAFG00000000760 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4216 |
| GADD45A | GeneProduct | ensembl:ENSCAFG00000029474 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1647 |
| MAP2K5 | GeneProduct | ensembl:ENSCAFG00000017454 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5607 |
| CDC25B | GeneProduct | ensembl:ENSCAFG00000006175 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:994 |
| IL1R1 | GeneProduct | ensembl:ENSCAFG00000002147 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3554 |
| RAC2 | GeneProduct | ensembl:ENSCAFG00000001508 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5880 |
| PRKCD | GeneProduct | ensembl:ENSCAFG00000008689 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5580 |
| PPP5C | GeneProduct | ensembl:ENSCAFG00000004313 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5536 |
| MAP2K1 | GeneProduct | ensembl:ENSCAFG00000017298 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5604 |
| RAC1 | GeneProduct | ensembl:ENSCAFG00000015716 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5879 |
| PTPN7 | GeneProduct | ensembl:ENSCAFG00000010591 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5778 |
| IL1R2 | GeneProduct | ensembl:ENSCAFG00000002152 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7850 |
| TAB2 | GeneProduct | ensembl:ENSCAFG00000000373 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23118 |
| TGFBR1 | GeneProduct | ensembl:ENSCAFG00000002528 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7046 |
| MAPK1 | GeneProduct | ensembl:ENSCAFG00000015421 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5594 |
| PTPRR | GeneProduct | ensembl:ENSCAFG00000023742 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5801 |
| PTPN5 | GeneProduct | ensembl:ENSCAFG00000009391 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:84867 |
| PLA2G4D | GeneProduct | ensembl:ENSCAFG00000024815 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000159337 |
| BRAF | GeneProduct | ensembl:ENSCAFG00000003907 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:673 |
| NTRK1 | GeneProduct | ensembl:ENSCAFG00000016528 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4914 |
| ATF2 | GeneProduct | ensembl:ENSCAFG00000013332 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1386 |
| MAP2K4 | GeneProduct | ensembl:ENSCAFG00000017851 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6416 |
| FOS | GeneProduct | ensembl:ENSCAFG00000017040 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2353 |
| PRKCG | GeneProduct | ensembl:ENSCAFG00000002713 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5582 |
| MYC | GeneProduct | ensembl:ENSCAFG00000001086 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4609 |
| SOS2 | GeneProduct | ensembl:ENSCAFG00000014275 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6655 |
| TGFB2 | GeneProduct | ensembl:ENSCAFG00000010815 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7042 |
| ELK1 | GeneProduct | ensembl:ENSCAFG00000015178 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2002 |
| MAPK7 | GeneProduct | ensembl:ENSCAFG00000018202 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5598 |
| DUSP4 | GeneProduct | ensembl:ENSCAFG00000030240 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1846 |
| CACNG3 | GeneProduct | ensembl:ENSCAFG00000017571 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = H:CACNG3 |
| HSPA8 | GeneProduct | ensembl:ENSCAFG00000001886 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3312 |
| MAPK12 | GeneProduct | ensembl:ENSCAFG00000000685 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6300 |
| MAPK8IP1 | GeneProduct | ensembl:ENSCAFG00000009363 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000121653 |
| PPM1A | GeneProduct | ensembl:ENSCAFG00000015603 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5494 |
| IL1B | GeneProduct | ensembl:ENSCAFG00000007249 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3553 |
| ELK4 | GeneProduct | ensembl:ENSCAFG00000010144 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158711 |
| TRAF2 | GeneProduct | ensembl:ENSCAFG00000019541 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7186 |
| MAPK13 | GeneProduct | ensembl:ENSCAFG00000001382 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5603 |
| TAOK1 | GeneProduct | ensembl:ENSCAFG00000018898 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57551 |
| MAP2K6 | GeneProduct | ensembl:ENSCAFG00000010758 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5608 |
| DUSP8 | GeneProduct | ensembl:ENSCAFG00000010009 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000184545 |
| AKT2 | GeneProduct | ensembl:ENSCAFG00000005388 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:208 |
| MAPKAPK5 | GeneProduct | ensembl:ENSCAFG00000008745 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8550 |
| RASA2 | GeneProduct | ensembl:ENSCAFG00000007674 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5922 |
| DUSP7 | GeneProduct | ensembl:ENSCAFG00000032027 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1849 |
| FGFR1 | GeneProduct | ensembl:ENSCAFG00000005970 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2260 |
| TGFB3 | GeneProduct | ensembl:ENSCAFG00000017101 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7043 |
| PPP3CA | GeneProduct | ensembl:ENSCAFG00000010644 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5530 |
| EGF | GeneProduct | ensembl:ENSCAFG00000011532 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1950 |
| DDIT3 | GeneProduct | ensembl:ENSCAFG00000030112 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1649 |
| MAP3K6 | GeneProduct | ensembl:ENSCAFG00000012144 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9064 |
| MAP3K8 | GeneProduct | ensembl:ENSCAFG00000003980 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1326 |
| NGF | GeneProduct | ensembl:ENSCAFG00000009739 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000134259 |
| CRKL | GeneProduct | ensembl:ENSCAFG00000015188 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1399 |
| TAOK2 | GeneProduct | ensembl:ENSCAFG00000017039 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9344 |
| MAPK3 | GeneProduct | ensembl:ENSCAFG00000018974 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5595 |
| MAPK8 | GeneProduct | ensembl:ENSCAFG00000006551 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5599 |
| NR4A1 | GeneProduct | ensembl:ENSCAFG00000007338 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3164 |
| PRKCA | GeneProduct | ensembl:ENSCAFG00000011326 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000154229 |
| ATF4 | GeneProduct | ensembl:ENSCAFG00000001324 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:468 |
| NTF4 | GeneProduct | ensembl:ENSCAFG00000003838 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000225950 |
| PDGFA | GeneProduct | ensembl:ENSCAFG00000011193 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000197461 |
| ATF4 | GeneProduct | ensembl:ENSCAFG00000001324 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:468 |
| NTRK2 | GeneProduct | ensembl:ENSCAFG00000001380 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000148053 |
| FASLG | GeneProduct | ensembl:ENSCAFG00000014678 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:356 |
| PDGFRB | GeneProduct | ensembl:ENSCAFG00000018214 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000113721 |
| PPM1B | GeneProduct | ensembl:ENSCAFG00000002535 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5495 |
| FGFR2 | GeneProduct | ensembl:ENSCAFG00000012374 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000066468 |
| CDC42 | GeneProduct | ensembl:ENSCAFG00000014707 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:998 |
| FGFR3 | GeneProduct | ensembl:ENSCAFG00000014993 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000068078 |
| LAMTOR3 | GeneProduct | ensembl:ENSCAFG00000029975 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8649 |
| FGFR4 | GeneProduct | ensembl:ENSCAFG00000016518 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000160867 |
| JUN | GeneProduct | ensembl:ENSCAFG00000018897 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3725 |
| SOS1 | GeneProduct | ensembl:ENSCAFG00000006340 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000115904 |
| JUND | GeneProduct | ensembl:ENSCAFG00000023338 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3727 |
| RRAS | GeneProduct | ensembl:ENSCAFG00000003604 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000126458 |
| HRAS | GeneProduct | ensembl:ENSCAFG00000031029 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000174775 |
| RPS6KA5 | GeneProduct | ensembl:ENSCAFG00000017543 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9252 |
| MAP3K12 | GeneProduct | ensembl:ENSCAFG00000006918 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7786 |
| TP53 | GeneProduct | ensembl:ENSCAFG00000016714 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7157 |
| RRAS2 | GeneProduct | ensembl:ENSCAFG00000008396 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000133818 |
| NFKB1 | GeneProduct | ensembl:ENSCAFG00000010730 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4790 |
| GNG12 | GeneProduct | ensembl:ENSCAFG00000028654 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000172380 |
| NF1 | GeneProduct | ensembl:ENSCAFG00000018592 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196712 |
| RASGRP2 | GeneProduct | ensembl:ENSCAFG00000014309 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000068831 |
| AKT1 | GeneProduct | ensembl:ENSCAFG00000018354 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:207 |
| RASGRP3 | GeneProduct | ensembl:ENSCAFG00000005870 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000152689 |
| RASGRP4 | GeneProduct | ensembl:ENSCAFG00000005909 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000171777 |
| RASA1 | GeneProduct | ensembl:ENSCAFG00000008410 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5921 |
| RASGRF1 | GeneProduct | ensembl:ENSCAFG00000014053 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000058335 |
| NTF3 | GeneProduct | ensembl:ENSCAFG00000015278 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000185652 |
| RAPGEF2 | GeneProduct | ensembl:ENSCAFG00000008719 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000109756 |
| PRKACB | GeneProduct | ensembl:ENSCAFG00000020319 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000142875 |
| STK3 | GeneProduct | ensembl:ENSCAFG00000000484 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6788 |
| DUSP3 | GeneProduct | ensembl:ENSCAFG00000028570 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000108861 |
| MAP4K3 | GeneProduct | ensembl:ENSCAFG00000006426 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8491 |
| CHUK | GeneProduct | ensembl:ENSCAFG00000009588 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000213341 |
| TGFBR2 | GeneProduct | ensembl:ENSCAFG00000005449 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7048 |
| NFKB2 | GeneProduct | ensembl:ENSCAFG00000010155 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000077150 |
| MAP4K2 | GeneProduct | ensembl:ENSCAFG00000014216 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000168067 |
| RELA | GeneProduct | ensembl:ENSCAFG00000013334 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000173039 |
| MAP2K7 | GeneProduct | ensembl:ENSCAFG00000031522 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5609 |
| RELB | GeneProduct | ensembl:ENSCAFG00000004597 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000104856 |
| DUSP9 | GeneProduct | ensembl:ENSCAFG00000019241 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000130829 |
| NLK | GeneProduct | ensembl:ENSCAFG00000018650 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51701 |
| DUSP2 | GeneProduct | ensembl:ENSCAFG00000023317 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158050 |
| DUSP16 | GeneProduct | ensembl:ENSCAFG00000013274 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000111266 |
| FAS | GeneProduct | ensembl:ENSCAFG00000015712 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:355 |
| MKNK2 | GeneProduct | ensembl:ENSCAFG00000019429 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000099875 |
| PLA2G4A | GeneProduct | ensembl:ENSCAFG00000013778 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000116711 |
| NFATC3 | GeneProduct | ensembl:ENSCAFG00000020324 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000072736 |
| MAP3K5 | GeneProduct | ensembl:ENSCAFG00000000251 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4217 |
| MAP3K11 | GeneProduct | ensembl:ENSCAFG00000013415 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4296 |
| TAOK3 | GeneProduct | ensembl:ENSCAFG00000009924 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000135090 |
| DUSP6 | GeneProduct | ensembl:ENSCAFG00000006100 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1848 |
| MAP2K2 | GeneProduct | ensembl:ENSCAFG00000019138 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5605 |
| RPS6KA4 | GeneProduct | ensembl:ENSCAFG00000031793 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000162302 |
| MAPKAPK3 | GeneProduct | ensembl:ENSCAFG00000010281 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000114738 |
| MAPK8IP2 | GeneProduct | ensembl:ENSCAFG00000000568 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000008735 |
| MAPK8IP3 | GeneProduct | ensembl:ENSCAFG00000019513 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138834 |
| FLNB | GeneProduct | ensembl:ENSCAFG00000007603 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000136068 |
| FLNC | GeneProduct | ensembl:ENSCAFG00000001585 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000128591 |
| HSPA1L | GeneProduct | ensembl:ENSCAFG00000000639 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000204390 |
| HSPA2 | GeneProduct | ensembl:ENSCAFG00000016031 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000126803 |
| MRAS | GeneProduct | ensembl:ENSCAFG00000007541 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:22808 |
| NRAS | GeneProduct | ensembl:ENSCAFG00000009532 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4893 |
| KRAS | GeneProduct | ensembl:ENSCAFG00000011428 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3845 |
| RAF1 | GeneProduct | ensembl:ENSCAFG00000004951 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5894 |
| PLA2G4F | GeneProduct | ensembl:ENSCAFG00000009914 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000168907 |
| PLA2G4B | GeneProduct | ensembl:ENSCAFG00000009735 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000243708 |
| PLA2G4E | GeneProduct | ensembl:ENSCAFG00000024908 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000188089 |
| CACNG2 | GeneProduct | ensembl:ENSCAFG00000029809 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000166862 |
| CACNG5 | GeneProduct | ensembl:ENSCAFG00000031724 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000075429 |
| CACNA2D3 | GeneProduct | ensembl:ENSCAFG00000008211 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000157445 |
| CACNG8 | GeneProduct | ensembl:ENSCAFG00000032667 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000142408 |
| CACNG7 | GeneProduct | ensembl:ENSCAFG00000002705 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000105605 |
| CACNG6 | GeneProduct | ensembl:ENSCAFG00000002704 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000130433 |
| CACNA1A | GeneProduct | ensembl:ENSCAFG00000016897 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000141837 |
| CACNA1B | GeneProduct | ensembl:ENSCAFG00000019380 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000148408 |
| CACNA1C | GeneProduct | ensembl:ENSCAFG00000016051 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000151067 |
| CACNA1D | GeneProduct | ensembl:ENSCAFG00000008525 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000157388 |
| CACNA1E | GeneProduct | ensembl:ENSCAFG00000013004 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000198216 |
| CACNA1F | GeneProduct | ensembl:ENSCAFG00000015873 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102001 |
| CACNA1S | GeneProduct | ensembl:ENSCAFG00000010884 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000081248 |
| CACNA2D1 | GeneProduct | ensembl:ENSCAFG00000006339 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000153956 |
| CACNB1 | GeneProduct | ensembl:ENSCAFG00000016510 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000067191 |
| CACNB2 | GeneProduct | ensembl:ENSCAFG00000004474 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000165995 |
| CACNB3 | GeneProduct | ensembl:ENSCAFG00000008857 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000167535 |
| CACNB4 | GeneProduct | ensembl:ENSCAFG00000005773 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000182389 |
| CACNG1 | GeneProduct | ensembl:ENSCAFG00000011372 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000108878 |
| CACNA1I | GeneProduct | ensembl:ENSCAFG00000001314 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000100346 |
| CACNA1H | GeneProduct | ensembl:ENSCAFG00000019596 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196557 |
| CACNA1G | GeneProduct | ensembl:ENSCAFG00000017120 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000006283 |
| CACNA2D2 | GeneProduct | ensembl:ENSCAFG00000010431 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000007402 |
| FGF4 | GeneProduct | ensembl:ENSCAFG00000029983 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2249 |
| FGF1 | GeneProduct | ensembl:ENSCAFG00000031965 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000113578 |
| FGF2 | GeneProduct | ensembl:ENSCAFG00000003996 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138685 |
| FGF3 | GeneProduct | ensembl:ENSCAFG00000010688 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000186895 |
| FGF4 | GeneProduct | ensembl:ENSCAFG00000029983 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000075388 |
| FGF5 | GeneProduct | ensembl:ENSCAFG00000008886 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138675 |
| FGF6 | GeneProduct | ensembl:ENSCAFG00000015361 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000111241 |
| FGF7 | GeneProduct | ensembl:ENSCAFG00000014923 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000140285 |
| FGF8 | GeneProduct | ensembl:ENSCAFG00000009918 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000107831 |
| FGF9 | GeneProduct | ensembl:ENSCAFG00000029890 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102678 |
| FGF10 | GeneProduct | ensembl:ENSCAFG00000032695 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000070193 |
| FGF11 | GeneProduct | ensembl:ENSCAFG00000028562 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000161958 |
| FGF12 | GeneProduct | ensembl:ENSCAFG00000031187 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000114279 |
| FGF13 | GeneProduct | ensembl:ENSCAFG00000032672 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000129682 |
| FGF14 | GeneProduct | ensembl:ENSCAFG00000005926 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102466 |
| FGF20 | GeneProduct | ensembl:ENSCAFG00000006845 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000078579 |
| FGF21 | GeneProduct | ensembl:ENSCAFG00000003904 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000105550 |
| FGF22 | GeneProduct | ensembl:ENSCAFG00000019707 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000070388 |
| FGF23 | GeneProduct | ensembl:ENSCAFG00000015365 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000118972 |
| FGF18 | GeneProduct | ensembl:ENSCAFG00000016903 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000156427 |
| FGF17 | GeneProduct | ensembl:ENSCAFG00000009749 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158815 |
| FGF16 | GeneProduct | ensembl:ENSCAFG00000029141 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196468 |
| FGF19 | GeneProduct | ensembl:ENSCAFG00000010693 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000162344 |
| PAK2 | GeneProduct | ensembl:ENSCAFG00000013067 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5062 |
| PAK1 | GeneProduct | ensembl:ENSCAFG00000004956 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5058 |
References
- Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Harper SJ, LoGrasso P. Cell Signal. 2001 May;13(5):299–310. PubMed Europe PMC Scholia
- MAP kinases. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, et al. Chem Rev. 2001 Aug;101(8):2449–76. PubMed Europe PMC Scholia
- Docking interactions in the mitogen-activated protein kinase cascades. Tanoue T, Nishida E. Pharmacol Ther. 2002;93(2–3):193–202. PubMed Europe PMC Scholia
- Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. Takeda K, Ichijo H. Genes Cells. 2002 Nov;7(11):1099–111. PubMed Europe PMC Scholia
- The role of mitogen-activated protein kinase pathways in Alzheimer’s disease. Zhu X, Lee H gon, Raina AK, Perry G, Smith MA. Neurosignals. 2002;11(5):270–81. PubMed Europe PMC Scholia
- Trk receptors: roles in neuronal signal transduction. Huang EJ, Reichardt LF. Annu Rev Biochem. 2003;72:609–42. PubMed Europe PMC Scholia
- Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, et al. Toxicol Lett. 2003 Aug 28;143(3):323–30. PubMed Europe PMC Scholia
- MAPK pathways in radiation responses. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. Oncogene. 2003 Sep 1;22(37):5885–96. PubMed Europe PMC Scholia
- Transcriptional regulation by the MAP kinase signaling cascades. Yang SH, Sharrocks AD, Whitmarsh AJ. Gene. 2003 Nov 27;320:3–21. PubMed Europe PMC Scholia
- MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta. Abell AN, Granger DA, Johnson GL. J Biol Chem. 2007 Oct 19;282(42):30476–84. PubMed Europe PMC Scholia
- (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, et al. Cell Death Differ. 2012 Oct;19(10):1623–33. PubMed Europe PMC Scholia