Interleukin-1 (IL-1) structural pathway (WP2637)

Homo sapiens

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IL-1 signaling pathway reconstructed by combining related pathways and information from the literature. This detailed map of IL-1 signaling presents the protein-protein interactions and the resulting cellular events. The colored nodes represent proteins having experimentally identified 3D structures and the white nodes are the proteins without 3D structures. The edges represent protein-protein interactions (straight/dashed arrows relate to available/unavailable 3D structures of proteins) or associations leading to cellular events such as cell cycle or gene expression (dashed arrows beginning with circular heads). doi:10.1371/journal.pcbi.1003470.g002 Pathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2637 CPTAC Assay Portal].

Authors

Andra Waagmeester , Martina Summer-Kutmon , Zahra Roudbari , Egon Willighagen , Marianthi Kalafati , Kristina Hanspers , Alex Pico , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway interleukin-1 signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
IL1A GeneProduct ensembl:ENSG00000115008
MYD88 GeneProduct ensembl:ENSG00000172936
TPL2 GeneProduct ensembl:ENSG00000107968
MEKK1 GeneProduct ensembl:ENSG00000095015
ELK1 GeneProduct ensembl:ENSG00000126767
IKKalpha GeneProduct ensembl:ENSG00000213341
IRAK4 GeneProduct ensembl:ENSG00000198001
IkapaBalpha GeneProduct uniprot:P25963
IRAK1 GeneProduct ensembl:ENSG00000184216
IRF7 GeneProduct ensembl:ENSG00000185507
TAK1 GeneProduct ensembl:ENSG00000135341
NF-kappaB p105 GeneProduct uniprot:P19838
MSK1 GeneProduct ensembl:ENSG00000100784
TRAF6 GeneProduct ensembl:ENSG00000175104
TOLLIP GeneProduct ensembl:ENSG00000078902
JNK1 GeneProduct uniprot:P45983
IRAK2 GeneProduct ensembl:ENSG00000134070
ERK1 GeneProduct ensembl:ENSG00000102882
IL1R1 GeneProduct ensembl:ENSG00000115594
MKK3 GeneProduct ensembl:ENSG00000034152
HSP27 GeneProduct ensembl:ENSG00000160633
NF-kappaB p65 GeneProduct ensembl:ENSG00000173039
NIK GeneProduct ensembl:ENSG00000006062
MAPKAPK2 GeneProduct ensembl:ENSG00000162889
TAB1 GeneProduct ensembl:ENSG00000100324
MEKK3 GeneProduct ensembl:ENSG00000198909
MAPKp38beta GeneProduct ensembl:ENSG00000185386
MBP GeneProduct ensembl:ENSG00000197971
IL1B GeneProduct ensembl:ENSG00000115008
IL1RAP GeneProduct ensembl:ENSG00000196083
TAB2 GeneProduct ensembl:ENSG00000055208
TAB3 GeneProduct ensembl:ENSG00000157625
MKK6 GeneProduct ensembl:ENSG00000108984
MKK4 GeneProduct ensembl:ENSG00000065559
MKK7 GeneProduct ensembl:ENSG00000076984
MKK1 GeneProduct ensembl:ENSG00000169032
MKK2 GeneProduct ensembl:ENSG00000126934
IKKgamma GeneProduct ensembl:ENSG00000136560
IKKbeta GeneProduct ensembl:ENSG00000104365
MAPKp38alpha GeneProduct ensembl:ENSG00000112062
JNK2 GeneProduct uniprot:P45984
JNK3 GeneProduct uniprot:P53779
ERK2 GeneProduct ensembl:ENSG00000100030
IkappaBbeta GeneProduct uniprot:Q15653
ATF2 GeneProduct ensembl:ENSG00000115966
Mnk1 GeneProduct ensembl:ENSG00000079277
c-Jun GeneProduct ensembl:ENSG00000050748
c-Fos GeneProduct ensembl:ENSG00000170345
c-Myc GeneProduct ensembl:ENSG00000136997
Mnk2 GeneProduct ensembl:ENSG00000099875
Histone H3 GeneProduct uniprot:Q66I33
eIF-4E GeneProduct ensembl:ENSG00000151247

References

  1. Mammalian MAP kinase signalling cascades. Chang L, Karin M. Nature. 2001 Mar 1;410(6824):37–40. PubMed Europe PMC Scholia
  2. Annotating genes with potential roles in the immune system: six new members of the IL-1 family. Dunn E, Sims JE, Nicklin MJ, O’Neill LA. Trends Immunol. 2001 Oct;22(10):533–6. PubMed Europe PMC Scholia
  3. A new nomenclature for IL-1-family genes. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, et al. Trends Immunol. 2001 Oct;22(10):536–7. PubMed Europe PMC Scholia
  4. Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions. Lawson C, Al-Akoum M, Maheux R, Akoum A. Reproduction. 2007 Jan;133(1):265–74. PubMed Europe PMC Scholia
  5. Cloning IL-1 and the birth of a new era in cytokine biology. Pizarro TT, Cominelli F. J Immunol. 2007 May 1;178(9):5411–2. PubMed Europe PMC Scholia
  6. The inflammasomes: guardians of the body. Martinon F, Mayor A, Tschopp J. Annu Rev Immunol. 2009;27:229–65. PubMed Europe PMC Scholia
  7. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM. EMBO J. 2012 Mar 21;31(6):1394–404. PubMed Europe PMC Scholia
  8. The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer. Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O. PLoS Comput Biol. 2014 Feb 13;10(2):e1003470. PubMed Europe PMC Scholia