GLP-1 from intestine and pancreas and role in glucose homeostasis (WP5452)

Homo sapiens

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Pathway of how GLP-1 produced in alpha cells in the pancreas may contribute to insulin secretion, in addition to GLP-1 from intestine. Based on Figure 4 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190119.

Authors

Eric Weitz and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

insulin secretion pathway glucagon signaling pathway glucagon secretion pathway glucagon biosynthetic pathway glucagon-like peptide-1 signaling pathway

Cell Type Ontology

pancreatic A cell insulin secreting cell type B pancreatic cell

Participants
Query Drugst.One

Label Type Compact URI Comment
Glucose Metabolite chebi:17234
Amino acid Metabolite chebi:33709
PCSK1 GeneProduct ensembl:ENSG00000175426
PCSK2 GeneProduct ensembl:ENSG00000125851
GLP1R GeneProduct ensembl:ENSG00000112164
INS GeneProduct ensembl:ENSG00000254647
GCG GeneProduct ensembl:ENSG00000115263
SLC2A1 GeneProduct ensembl:ENSG00000117394
Glucagon Protein wikidata:Q170617
Insulin Protein uniprot:P01308
GLP-1 Protein wikidata:Q424611

References

  1. Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function. Davis EM, Sandoval DA. Compr Physiol. 2020 Mar 12;10(2):577–95. PubMed Europe PMC Scholia