Hedgehog signaling pathway (WP492)

Drosophila melanogaster

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The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Authors

Akhilesh Pandey , Alex Pico , Christine Chichester , Kristina Hanspers , Ryan Miller , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Drosophila melanogaster

Communities

Annotations

Pathway Ontology

Hedgehog signaling pathway

Participants

Label Type Compact URI Comment
ptc GeneProduct ncbigene:35851
hh GeneProduct ncbigene:42737
cdc2 GeneProduct ncbigene:34411
smo GeneProduct ncbigene:33196
ci GeneProduct ncbigene:43767
snoN GeneProduct ncbigene:34085
Su(fu) GeneProduct ncbigene:41565
Bin1 GeneProduct ncbigene:41965
Sin3A GeneProduct ncbigene:36382
mnb GeneProduct ncbigene:32772
CycB GeneProduct ncbigene:37618
Rab23 GeneProduct ncbigene:40701

References

  1. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Mohler J. Genetics. 1988 Dec;120(4):1061–72. PubMed Europe PMC Scholia
  2. The Hedgehog response network: sensors, switches, and routers. Lum L, Beachy PA. Science. 2004 Jun 18;304(5678):1755–9. PubMed Europe PMC Scholia