Intracellular auxin transport (WP3628)

Arabidopsis thaliana

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In addition to the PIN family proteins that are mainly involved in the intercellular Autin transport via the Auxin Polar Transport pathway (WP2941) mediated by PIN proteins located on the plasmamembrane, the Arabidopsis PIN family members PIN5, PIN6 and PIN8 are located on the endoplasmic reticulum membrane/envelope. PIN6 is also likely co-located with the nuclear membrane. According to Sawchuk MG et al. (2013) PIN5, PIN6 and PIN8 play roles in leaf vein patterning. PIN5 and PIN8 play an antagonistic role in regulating the intercellular auxin transport as well as in gametophyte (pollen) and sporophyte development. Not much is known about the direction of auxin flow mediated by the PILS. However, they help in increasing the free auxin amount in the cytoplasm.

Authors

Pankaj Jaiswal , Kristina Hanspers , Eric Weitz , Finterly Hu , and Egon Willighagen

Activity

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Organisms

Arabidopsis thaliana

Communities

Annotations

Pathway Ontology

signaling pathway

Participants

Label Type Compact URI Comment
IAA Metabolite chebi:16411
PILS3 GeneProduct ensembl:AT1G76520
PILS6 GeneProduct ensembl:AT5G01990
PILS2 GeneProduct ensembl:AT1G71090
PILS5 GeneProduct ensembl:AT2G17500
PILS4 GeneProduct ensembl:AT1G76530
PILS7 GeneProduct ensembl:AT5G65980
PILS1 GeneProduct ensembl:AT1G20925
PIN5 Protein ensembl:AT5G16530
PIN8 Protein ensembl:AT5G15100
PIN6 Protein ensembl:AT1G77110

References

  1. Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter. Mravec J, Skůpa P, Bailly A, Hoyerová K, Krecek P, Bielach A, et al. Nature. 2009 Jun 25;459(7250):1136–40. PubMed Europe PMC Scholia
  2. A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants. Barbez E, Kubeš M, Rolčík J, Béziat C, Pěnčík A, Wang B, et al. Nature. 2012 Apr 15;485(7396):119–22. PubMed Europe PMC Scholia
  3. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. Ding Z, Wang B, Moreno I, Dupláková N, Simon S, Carraro N, et al. Nat Commun. 2012 Jul 3;3:941. PubMed Europe PMC Scholia
  4. Patterning of leaf vein networks by convergent auxin transport pathways. Sawchuk MG, Edgar A, Scarpella E. PLoS Genet. 2013;9(2):e1003294. PubMed Europe PMC Scholia
  5. PIN6 is required for nectary auxin response and short stamen development. Bender RL, Fekete ML, Klinkenberg PM, Hampton M, Bauer B, Malecha M, et al. Plant J. 2013 Jun;74(6):893–904. PubMed Europe PMC Scholia
  6. PIN proteins and the evolution of plant development. Bennett T. Trends Plant Sci. 2015 Aug;20(8):498–507. PubMed Europe PMC Scholia