Alanine and aspartate metabolism (WP106)

Homo sapiens

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Converted from rat to human using ortholog information, originally from KEGG. Originally edited by Sebastien Burel. This pathway describes the metabolism of amino acids alanine and aspartate. Alanine is broken down by oxidative deamination, the inverse reaction of the reductive amination biosynthesis, catalyzed by the same enzymes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP106 CPTAC Assay Portal]

Authors

Lynn M. Ferrante , Kristina Hanspers , Andra Waagmeester , Michiel Adriaens , Martijn Van Iersel , Alex Pico , Christine Chichester , Egon Willighagen , Martina Summer-Kutmon , and Daniela Digles

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

amino acid metabolic pathway alanine, aspartate and glutamate metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Pyruvate Metabolite chebi:32816
L-Alanine Metabolite chebi:16977
N-Carbamoyl-L-aspartate Metabolite chebi:15859
D-Alanine Metabolite cas:338-69-2 D-Alanine
b-Alanine Metabolite chebi:16958 beta-alanine
L-Asparagine acid Metabolite cas:70-47-3
Acetyl-CoA Metabolite cas:72-89-9 Acetyl-CoA
L-Aspartic acid Metabolite kegg.compound:C00049
N-Acetyl-L-aspartate Metabolite wikidata:Q28000013
Malate Metabolite cas:6915-15-7 (S)-Malate
Succinate Metabolite kegg.compound:C00042
Malonate semialdehyde Metabolite chebi:33190
Citric acid Metabolite hmdb:HMDB0000094
Adenylosuccinate Metabolite chebi:15919
Oxaloacetate Metabolite kegg.compound:C00036
L-Asparagine Metabolite cas:70-47-3 L-Asparagine
2-Oxoglutarate Metabolite kegg.compound:C00026
O-Acetylcarnitine Metabolite cas:3040-38-8
Carnosine Metabolite cas:305-84-0 Carnosine
D-aspartate Metabolite kegg.compound:C00402
Fumarate Metabolite kegg.compound:C00122
L-aspartate Metabolite kegg.compound:C00049
2-Oxosuccinamate Metabolite chebi:57735
L-Argininosuccinate Metabolite chebi:15682
3.5.1.3 GeneProduct eccode:3.5.1.3
GOT2 GeneProduct ncbigene:2806
3.4.13.3 GeneProduct eccode:3.4.13.3
ASL GeneProduct ncbigene:435
ABAT GeneProduct ncbigene:18
4.1.1.11 GeneProduct eccode:4.1.1.11
1.4.3.2 GeneProduct eccode:1.4.3.2
4.1.1.12 GeneProduct eccode:4.1.1.12
DARS GeneProduct ncbigene:1615
ASPA GeneProduct ncbigene:443
5.1.1.1 GeneProduct eccode:5.1.1.1
2.6.1.12 GeneProduct eccode:2.6.1.12
AGXT GeneProduct ncbigene:189
6.3.1.1 GeneProduct eccode:6.3.1.1
1.2.1.18 GeneProduct eccode:1.2.1.18
5.1.1.13 GeneProduct eccode:5.1.1.13
GPT GeneProduct ncbigene:2875
3.5.1.7 GeneProduct eccode:3.5.1.7
6.3.5.6 GeneProduct eccode:6.3.5.6
3.5.1.38 GeneProduct eccode:3.5.1.38
4.3.1.1 GeneProduct eccode:4.3.1.1
2.3.1.7 GeneProduct eccode:2.3.1.7
1.4.3.15 GeneProduct eccode:1.4.3.15
3.5.1.1 GeneProduct eccode:3.5.1.1
6.3.2.11 GeneProduct eccode:6.3.2.11
1.4.3.16 GeneProduct eccode:1.4.3.16
6.1.1.22 GeneProduct eccode:6.1.1.22
2.6.1.18 GeneProduct eccode:2.6.1.18
2.6.1.14 GeneProduct eccode:2.6.1.14
6.1.1.7 GeneProduct eccode:6.1.1.7
GAD2 GeneProduct ncbigene:2572
GAD1 GeneProduct ncbigene:2571
1.4.3.1 GeneProduct eccode:1.4.3.1
ASS GeneProduct ncbigene:445
6.3.4.4 GeneProduct eccode:6.3.4.4
2.1.3.2 GeneProduct eccode:2.1.3.2
4.3.2.2 GeneProduct eccode:4.3.2.2
PC GeneProduct ncbigene:5091
GOT1 GeneProduct ncbigene:2805
6.3.5.4 GeneProduct eccode:6.3.5.4

References

  1. Intestinal mucosal amino acid catabolism. Wu G. J Nutr. 1998 Aug;128(8):1249–52. PubMed Europe PMC Scholia
  2. Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters. Curien G, Bastien O, Robert-Genthon M, Cornish-Bowden A, Cárdenas ML, Dumas R. Mol Syst Biol. 2009;5:271. PubMed Europe PMC Scholia