PDGF pathway (WP3200)

Bos taurus

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PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds made between the 1st

Authors

Martina Summer-Kutmon , Egon Willighagen , Ryan Miller , Daniela Digles , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

platelet-derived growth factor signaling pathway Jak-Stat signaling pathway

Disease Ontology

cancer

Participants

Label Type Compact URI Comment
Cyclic AMP(cAMP) Metabolite hmdb:HMDB0000058
DAG Metabolite lipidmaps:LMGL02010000
Prostaglandin I2(PGI2) Metabolite hmdb:HMDB0001335
IP3 Metabolite chebi:16595
PIP2[4',5'] Metabolite lipidmaps:LMGP08010003
Ca2+ Metabolite chebi:29108
Phospholipid(containing arachidonic acid) Metabolite chebi:16247
[Ca2+]i Metabolite chebi:29108
Arachidonic acid Metabolite hmdb:HMDB0001043
H+ Metabolite chebi:15378
Na Metabolite chebi:29101
JUN GeneProduct ensembl:ENSBTAG00000004037 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P05412
RASA1 GeneProduct ensembl:ENSBTAG00000009565 Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000145715
PTPN11 GeneProduct ensembl:ENSBTAG00000002048 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q06124
PDGFRB GeneProduct ensembl:ENSBTAG00000002804 Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000113721
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P45983
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5595
MAP2K4 GeneProduct ensembl:ENSBTAG00000012103 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416
PLCG1 GeneProduct ensembl:ENSBTAG00000017584 Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000124181
PDGFA GeneProduct ensembl:ENSBTAG00000014541 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5154
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5594
MAP3K1 GeneProduct ensembl:ENSBTAG00000013790 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q13233
PDGFB GeneProduct ensembl:ENSBTAG00000021697 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5155
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q02750
HRAS GeneProduct ensembl:ENSBTAG00000046644 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3265
PLA2G4A GeneProduct ensembl:ENSBTAG00000013298 Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000116711
ELK1 GeneProduct ensembl:ENSBTAG00000015817 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P19419
FOS GeneProduct ensembl:ENSBTAG00000004322 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P01100
SRF GeneProduct ensembl:ENSBTAG00000012777 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P11831
NFKBIA GeneProduct ensembl:ENSBTAG00000016683 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P25963
GRB2 Protein ensembl:ENSBTAG00000004736 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P62993
STAT1 Protein ensembl:ENSBTAG00000007867 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P42224
STAT3 Protein ensembl:ENSBTAG00000021523 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P40763
SOS1 Protein ensembl:ENSBTAG00000011643 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q07889
RAF1 Protein ensembl:ENSBTAG00000004514 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P04049
SHC1 Protein ensembl:ENSBTAG00000019838 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P29353
JAK1 Protein ensembl:ENSBTAG00000003147 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P23458
MT-CO2 Protein ensembl:ENSBTAG00000043556 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P00403
PIK3R1 Protein ensembl:ENSBTAG00000010989 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P27986
SRC Protein ensembl:ENSBTAG00000008938 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P12931
TIAM1 Protein ensembl:ENSBTAG00000017839 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q13009
VAV2 Protein ensembl:ENSBTAG00000004511 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P52735
RAC1 Protein ensembl:ENSBTAG00000009233 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P63000
RHOA Protein ensembl:ENSBTAG00000004279 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P61586
ARFIP2 Protein ensembl:ENSBTAG00000003566 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P53365
PAK1 Protein ensembl:ENSBTAG00000010191 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q13153
VAV1 Protein ensembl:ENSBTAG00000039160 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P15498
WASL Protein ensembl:ENSBTAG00000004643 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:O00401
CHUK Protein ensembl:ENSBTAG00000007591 Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:O15111

References

  1. PDGF: a multifunctional growth factor. Antoniades HN. Baillieres Clin Endocrinol Metab. 1991 Dec;5(4):595–613. PubMed Europe PMC Scholia
  2. PDGF and the small inducible gene (SIG) family: roles in the inflammatory response. Kawahara RS, Deng ZW, Deuel TF. Adv Exp Med Biol. 1991;305:79–87. PubMed Europe PMC Scholia
  3. Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors. Claesson-Welsh L, Heldin CH. Acta Oncol. 1989;28(3):331–4. PubMed Europe PMC Scholia
  4. Structure and function of platelet-derived growth factor (PDGF) and related proteins. Hannink M, Donoghue DJ. Biochim Biophys Acta. 1989 Jul 28;989(1):1–10. PubMed Europe PMC Scholia
  5. Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors. Heldin CH, Westermark B. Br Med Bull. 1989 Apr;45(2):453–64. PubMed Europe PMC Scholia
  6. Structural and functional aspects of platelet-derived growth factor. Heldin CH, Hammacher A, Nistér M, Westermark B. Br J Cancer. 1988 Jun;57(6):591–3. PubMed Europe PMC Scholia
  7. Role of platelet-derived growth factors in physiology and medicine. Andrae J, Gallini R, Betsholtz C. Genes Dev. 2008 May 15;22(10):1276–312. PubMed Europe PMC Scholia
  8. PDGF function in diverse neural crest cell populations. Smith CL, Tallquist MD. Cell Adh Migr. 2010;4(4):561–6. PubMed Europe PMC Scholia
  9. PDGF: the nuts and bolts of signalling toolbox. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, et al. Tumour Biol. 2011 Dec;32(6):1057–70. PubMed Europe PMC Scholia
  10. Autocrine PDGF stimulation in malignancies. Heldin CH. Ups J Med Sci. 2012 May;117(2):83–91. PubMed Europe PMC Scholia