EGF signaling in vulval development (WP2221)

Caenorhabditis elegans

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EGF signaling is a key pathway involved in vulval patterning. Vulval precursor cell patterning requires input and cooperation between both EGF LIN-3 graded signaling through LET-23 as well as a sequential, subordinate signal involving DSL ligands acting via LIN-12. See figure 8 here: http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf

Authors

Karen Yook , Christine Chichester , Eric Weitz , Stefan Raats , Kristina Hanspers , and Egon Willighagen

Activity

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Organisms

Caenorhabditis elegans

Communities

Annotations

Pathway Ontology

Ras mediated signaling pathway epidermal growth factor/neuregulin signaling pathway epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact URI Comment
LIN-3 GeneProduct ensembl:WBGene00002992
LET-23 GeneProduct ensembl:WBGene00002299
SEM-5 GeneProduct ensembl:WBGene00004774
SOS-1 GeneProduct ensembl:WBGene00004947
LET-60 GeneProduct ensembl:WBGene00002335
LIN-45 GeneProduct ensembl:WBGene00003030
MEK-2 GeneProduct ensembl:WBGene00003186
MPK-1 GeneProduct ensembl:WBGene00003401
LIN-31 GeneProduct ensembl:WBGene00003017
LIN-1 GeneProduct ensembl:WBGene00002990
lin-39 GeneProduct ensembl:WBGene00003024
egl-17 GeneProduct ensembl:WBGene00001185

References

  1. Vulval development. Sternberg PW. WormBook. 2005 Jun 25;1–28. PubMed Europe PMC Scholia