Metabolic pathways of fibroblasts (WP5312)
Homo sapiens
Fibroblasts are known to contribute to tissue and organ connectivity by producing and secreting extracellular matrix (ECM) proteins. Although several diseases, such as fibrosis and cancer, have been linked to changes in fibroblast metabolism, the resting metabolic conditions that are present in healthy cells generally go unreported. Because fibroblasts are known to display heterogeneity, the metabolic processes of different tissues may vary. The aim was to identify and map out the general metabolic pathways present in fibroblasts. The pathways for collagen, serine, and proline, as well as glycosaminoglycan synthesis, are nearly complete. Nonetheless, dashed arrows indicate missing process steps that should be identified and included. There is a lack of data on fibroblasts' metabolic activities, and further research is required to understand the complete metabolic pathways of fibroblasts.
Authors
AliHbdl , Jgumbaragyte , Ecenazertan , Eric Weitz , Mariamierzejewska , Alippifed , MatejKrivulka , Egon Willighagen , Andra Waagmeester , and Alex PicoActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
classic metabolic pathwayDisease Ontology
pulmonary fibrosisCell Type Ontology
fibroblast| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Heparan sulfate | Metabolite | hmdb:HMDB00693 | |
| Hyaluronic acid | Metabolite | hmdb:HMDB02061 | |
| Chondroitin sulfate | Metabolite | chebi:37397 | |
| Keratan sulfate | Metabolite | chebi:60924 | |
| UDP-GlcA | Metabolite | chebi:17200 | |
| Fatty acid | Metabolite | chebi:35366 | |
| Dermatan sulfate | Metabolite | hmdb:HMDB00632 | |
| Glycine | Metabolite | chebi:15428 | |
| Proline | Metabolite | chebi:17203 | |
| P5C | Metabolite | chebi:15893 | |
| Collagen | Metabolite | chebi:3815 | |
| Serine | Metabolite | chebi:17822 | |
| Glutamate | Metabolite | chebi:29985 | |
| G6P | Metabolite | hmdb:HMDB01401 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB01206 | |
| Pyruvate | Metabolite | hmdb:HMDB00243 | |
| Glutamine | Metabolite | chebi:18050 | |
| αKG | Metabolite | hmdb:HMDB00208 | |
| Glucose | Metabolite | hmdb:HMDB00122 | |
| 3PG | Metabolite | hmdb:HMDB00807 | |
| F6P | Metabolite | chebi:15946 | |
| Lactic acid | Metabolite | hmdb:HMDB00190 | |
| Glutamine | Metabolite | chebi:18050 | |
| L-glutamate | Metabolite | chebi:29985 | |
| Glutamine | Metabolite | chebi:18050 | |
| Glucose | Metabolite | hmdb:HMDB00122 | |
| Lactic acid | Metabolite | hmdb:HMDB00190 | |
| G1P | Metabolite | chebi:29042 | |
| UDP-glucose | Metabolite | chebi:18066 | |
| GSAL | Metabolite | wikidata:Q2823261 | |
| Fatty acid | Metabolite | chebi:35366 | |
| FGFR1 | GeneProduct | uniprot:P11362 | Full name: Fibroblast growth factor receptor 1 Gene: FGFR1 |
| CD36 | GeneProduct | uniprot:P16671 | Full name: Platelet glycoprotein 4 Gene: CD36 |
| G6PI | GeneProduct | uniprot:P06744 | Full name: Glucose-6-phosphate isomerase Gene: GPI |
| P3H4 | GeneProduct | uniprot:Q92791 | Full name: Endoplasmic reticulum protein SC65 Gene: P3H4 |
| LPAR1 | GeneProduct | ensembl:ENSG00000198121 | |
| LOX | GeneProduct | uniprot:Q9Y4K0 | Full name: Lysyl oxidase homolog 2 Gene: LOXL2 |
| BMP1 | GeneProduct | uniprot:P13497 | Full name: Bone morphogenetic protein 1 Gene: BMP1 |
| FGFR4 | GeneProduct | uniprot:P22455 | Full name: Fibroblast growth factor receptor 4 Gene: FGFR4 |
| ADAMTS2 | GeneProduct | uniprot:O95450 | Full name: A disintegrin and metalloproteinase with thrombospondin motifs 2 Gene: ADAMTS2 |
| P3H3 | GeneProduct | uniprot:Q8IVL6 | Full name: Prolyl 3-hydroxylase 3 Gene: P3H3 |
| Hsp47 | GeneProduct | uniprot:P50454 | Full name: Serpin H1 Gene: SERPINH1 |
| LDH | GeneProduct | uniprot:P00338 | Full name: L-lactate dehydrogenase A chain Gene: LDHA |
| SLC1A5 | GeneProduct | uniprot:Q15758 | Full name: Neutral amino acid transporter B(0) Gene: SLC1A5 |
| PLOD1 | GeneProduct | uniprot:Q02809 | Full name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Gene: PLOD1 |
| P4HA3 | GeneProduct | uniprot:Q7Z4N8 | Full name: Prolyl 4-hydroxylase subunit alpha-3 Gene: P4HA3 |
| P4HA1 | GeneProduct | uniprot:P13674 | Full name: Prolyl 4-hydroxylase subunit alpha-1 Gene: P4HA1 |
| P4HA2 | GeneProduct | uniprot:O15460 | Full name: Prolyl 4-hydroxylase subunit alpha-2 Gene: P4HA2 |
| SLC1A5 | GeneProduct | uniprot:Q15758 | Full name: Neutral amino acid transporter B(0) Gene: SLC1A5 |
| UGDH | Protein | uniprot:O60701 | |
| P5CR | Protein | uniprot:P32322 | Full name: Pyrroline-5-carboxylate reductase 1, mitochondrial Gene: PYCR1 |
| GLUT1 | Protein | uniprot:P11166 | Full name: Solute carrier family 2, facilitated glucose transporter member 1 Gene: SLC2A1 |
| GLS | Protein | uniprot:O94925 | Full name: Glutaminase kidney isoform, mitochondrial Gene: GLS |
| GLDH | Protein | uniprot:P00367 | Full name: Glutamate dehydrogenase 1 Gene: GLUD1 |
| SHMT | Protein | uniprot:O62585 | Full name: Serine hydroxymethyltransferase, cytosolic Gene: SHMT1 |
| UGP2 | Protein | uniprot:Q16851 | Full name: UTP--glucose-1-phosphate uridylyltransferase Gene: UGP2 |
| PHGDH | Protein | uniprot:O43175 | Full name: D-3-phosphoglycerate dehydrogenase Gene: PHGDH |
| RhoA | Protein | uniprot:P61586 | Full name: Transforming protein RhoA/Ras homolog family member A Gene: RHOA |
| P5CS | Protein | uniprot:P54886 | Full name: Delta-1-pyrroline-5-carboxylate synthase Gene: ALDH18A1 |
| PSP | Protein | uniprot:P78330 | Full name: Phosphoserine phosphatase Gene: PSPH |
| PLC | Protein | uniprot:P19174 | Full name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene: PLCG1 |
| PSA | Protein | uniprot:Q9Y617 | Full name: Phosphoserine aminotransferase Gene: PSAT1 |
| HK | Protein | uniprot:P35557 | Full name: Hexokinase-4 Gene: GCK |
| GLS | Protein | uniprot:O94925 | Full name: Glutaminase kidney isoform, mitochondrial Gene: GLS |
| MCT1 | Protein | uniprot:P53985 | Full name: Monocarboxylate transporter 1 Gene: SLC16A1 |
| PGM1 | Protein | uniprot:P36871 | Full name: Phosphoglucomutase-1 Gene: PGM1 |
| BMP1 | Protein | uniprot:P13497 | Full name: Bone morphogenetic protein 1 Gene: BMP1 |
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