Estrogen signaling (WP712)
Homo sapiens
Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP712 CPTAC Assay Portal]
Authors
Laura Van Zon , Kristina Hanspers , Chun Chen , Jildau Bouwman , Alex Pico , Lauren J. Dupuis , Egon Willighagen , and Eric WeitzActivity
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Cited In
- An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer (2019).
- MicroRNA expression profiling of Xp11 renal cell carcinoma (2017).
- MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
estrogen signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Estradiol | Metabolite | hmdb:HMDB0000151 | |
| Growth factors | Metabolite | hmdb:HMDB0000151 | |
| Cyclic AMP | Metabolite | hmdb:HMDB0000058 | |
| C-FOS | GeneProduct | ncbigene:2353 | |
| SP1 | GeneProduct | ncbigene:6667 | |
| ERE | GeneProduct | ncbigene:2099 | |
| ER-AF1 | GeneProduct | ncbigene:2099 | |
| ELK | GeneProduct | ncbigene:2002 | |
| ERK 1/2 | GeneProduct | ensembl:ENSG00000100030 | |
| ER | GeneProduct | ncbigene:2099 | |
| ER-AF2 | GeneProduct | ncbigene:2099 | |
| GPR30 | GeneProduct | ncbigene:2852 | |
| c-Jun | GeneProduct | ncbigene:3725 | |
| PI3K | GeneProduct | ncbigene:5290 | |
| NFKB | GeneProduct | ncbigene:4790 | |
| Non-ERE | GeneProduct | ncbigene:2099 | |
| BCL2 apoptotic switch | GeneProduct | ncbigene:596 | |
| GFRs | GeneProduct | ncbigene:2099 | |
| GNGT1 | GeneProduct | ncbigene:2792 | |
| GNB1 | GeneProduct | ncbigene:2782 | |
| PKB/Akt | GeneProduct | ncbigene:207 | |
| CREB | GeneProduct | ncbigene:1385 | |
| MAPKKK | GeneProduct | ncbigene:673 | |
| JNKs | GeneProduct | ncbigene:5601 | |
| GSA | GeneProduct | ncbigene:2778 | |
| p38 | GeneProduct | ncbigene:1432 | |
| MAPKK | GeneProduct | ensembl:ENSG00000169032 | |
| PKACA | GeneProduct | ncbigene:5566 | |
| CHUK | GeneProduct | ncbigene:1147 | |
| TF | GeneProduct | ncbigene:2099 | |
| IKBKB | GeneProduct | ncbigene:3551 | |
| IKBKG | GeneProduct | ncbigene:8517 |
References
- TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
- IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
- Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia