GPCRs, other (WP117)

Homo sapiens

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This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP117 CPTAC Assay Portal]

Authors

Nathan Salomonis , Bruce Conklin , Kristina Hanspers , Alex Pico , Egon Willighagen , Zahra Roudbari , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
GPR84 GeneProduct ncbigene:53831
RLN3R1 GeneProduct ncbigene:51289
TAAR3 GeneProduct ncbigene:9288
TAAR2 GeneProduct ncbigene:9287
GPR77 GeneProduct ncbigene:27202
GPR55 GeneProduct ncbigene:9290
GPR145 GeneProduct ncbigene:84539
GPR88 GeneProduct ncbigene:54112
GPR62 GeneProduct ncbigene:118442
GPR135 GeneProduct ncbigene:64582
GPR GeneProduct ncbigene:11245
TAAR5 GeneProduct ncbigene:9038
VN1R1 GeneProduct ncbigene:57191
HRH4 GeneProduct ncbigene:59340
CCR5 GeneProduct ncbigene:1234
OR7E24 GeneProduct ncbigene:26648
CELSR3 GeneProduct ncbigene:1951
GNRHR GeneProduct ncbigene:2798
P47889 GeneProduct uniprot:P47889
OR8G2 GeneProduct ncbigene:26492
OR8G1 GeneProduct ncbigene:26494
FSHR GeneProduct ncbigene:2492
F2R GeneProduct ncbigene:2149
ADORA2A GeneProduct ncbigene:135
EDG1 GeneProduct ncbigene:1901
OR10A5 GeneProduct ncbigene:144124
NTSR1 GeneProduct ncbigene:4923
LGR6 GeneProduct ncbigene:59352
HSA8 GeneProduct uniprot:Q9NZP0
HSA3 GeneProduct uniprot:Q9NZP2
HSA12 GeneProduct uniprot:Q9NZP3
HSA10 GeneProduct uniprot:Q9NZP4
HSA1 GeneProduct uniprot:Q9NZP5
HTR1F GeneProduct ncbigene:3355
HTR2A GeneProduct ncbigene:3356
IL8RB GeneProduct ncbigene:3579
IL8RA GeneProduct ncbigene:3577
Q9UEB1 GeneProduct ensembl:ENSG00000185385
OR10A2 GeneProduct ncbigene:341276
UTS2R GeneProduct ncbigene:2837
GPR143 GeneProduct ncbigene:4935
LTB4R2 GeneProduct ncbigene:56413
GPR61 GeneProduct ncbigene:83873
GPR56 GeneProduct ncbigene:9289
GPR116 GeneProduct ncbigene:221395
P2RY13 GeneProduct ncbigene:53829
GPR132 GeneProduct ncbigene:29933
GPR73L1 GeneProduct ncbigene:128674
GPR133 GeneProduct ncbigene:283383
GPR18 GeneProduct ncbigene:2841
OR10A1 GeneProduct ncbigene:144124
CCR2 GeneProduct ncbigene:1231
ADRA1D GeneProduct ncbigene:146
ADORA3 GeneProduct ncbigene:140
ADRB2 GeneProduct ncbigene:154
OR7E18P GeneProduct ncbigene:390885
OR7E19P GeneProduct ncbigene:26651
OR7E35P GeneProduct ncbigene:391632
HTR7 GeneProduct ncbigene:3363
LGR7 GeneProduct ncbigene:59350
OR2M4 GeneProduct ncbigene:26245
OR5-85 GeneProduct uniprot:P30953
OR5D3P GeneProduct ncbigene:8594
OR5E1P GeneProduct ensembl:ENSG00000170688
OR3A4 GeneProduct ensembl:ENSG00000180068
OR2A20P GeneProduct ncbigene:401428
OR2B6 GeneProduct ncbigene:26212
OR1F1 GeneProduct ncbigene:4992
OR2A9P GeneProduct ensembl:ENSG00000228960
OR1N1 GeneProduct ncbigene:138883
OR1E1 GeneProduct ncbigene:8387
OR1G1 GeneProduct ncbigene:8390
OR1E3P GeneProduct ncbigene:8389
OR1R1P GeneProduct ncbigene:9596
OR2F1 GeneProduct ncbigene:26211
OR3A1 GeneProduct ncbigene:4994
OR2H1 GeneProduct ncbigene:26716
OR2A5 GeneProduct ncbigene:393046
OR5D3 GeneProduct uniprot:O95220
OR3A3 GeneProduct ncbigene:8392
GPR17 GeneProduct ncbigene:2840
CELSR2 GeneProduct ncbigene:1952
CELSR1 GeneProduct ncbigene:9620
O60411 GeneProduct uniprot:O60411
OR51A1P GeneProduct ncbigene:26537
GRM8 GeneProduct ncbigene:2918
OR2A4 GeneProduct ncbigene:79541
Q9BYT4 GeneProduct uniprot:Q9BYT4
Q9H2C7 GeneProduct uniprot:Q9H2C7
GRPR GeneProduct ncbigene:2925
OR1J5 GeneProduct ncbigene:81370
CNR1 GeneProduct ncbigene:1268
CHRM3 GeneProduct ncbigene:1131
CHRM2 GeneProduct ncbigene:1129
CCKBR GeneProduct ncbigene:887
CXCR3 GeneProduct ncbigene:2833
GHRHR GeneProduct ncbigene:2692
GRCA GeneProduct ncbigene:27239
GPR83 GeneProduct ncbigene:10888
GRM1 GeneProduct ncbigene:2911
DRD3 GeneProduct ncbigene:1814
DRD4 GeneProduct ncbigene:1815
EMR2 GeneProduct ncbigene:30817
EBI2 GeneProduct ncbigene:1880
EDNRA GeneProduct ncbigene:1909
EMR3 GeneProduct ncbigene:84658
FY GeneProduct ncbigene:2532
ALG6 GeneProduct ncbigene:29929
P2RY11 GeneProduct ncbigene:5032
MASS1 GeneProduct ncbigene:84059
LPHN3 GeneProduct ncbigene:23284
LPHN2 GeneProduct ncbigene:23266
PTGFR GeneProduct ncbigene:5737
SSTR2 GeneProduct ncbigene:6752
SMO GeneProduct ncbigene:6608

References

  1. GPCRDB: an information system for G protein-coupled receptors. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Classifying G-protein coupled receptors with support vector machines. Karchin R, Karplus K, Haussler D. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia