Ketone bodies synthesis and degradation (WP1015)

Bos taurus

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Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]

Authors

Thomas Kelder , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

ketone bodies metabolic pathway ketone bodies biosynthetic pathway ketone bodies degradation pathway

Participants

Label Type Compact URI Comment
Acetyl-CoA Metabolite cas:72-89-9
Acetoacetyl-CoA Metabolite cas:1420-36-6
3-Hydroxy-3-methylglutaryl-CoA Metabolite cas:1553-55-5
Acetyl-CoA Metabolite cas:72-89-9
3-Hydroxy-butyrate Metabolite pubchem.compound:441
Acetoacetate Metabolite pubchem.compound:6971017
ACAT1 GeneProduct ensembl:ENSBTAG00000012885 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:38
HMGCS2 GeneProduct ensembl:ENSBTAG00000003898 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3158
HMGCL GeneProduct ensembl:ENSBTAG00000021832 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3155
OXCT1 GeneProduct ensembl:ENSBTAG00000033186 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5019
BDH1 GeneProduct ensembl:ENSBTAG00000000448 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:622

References

  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia