Ketone bodies synthesis and degradation (WP1015)

Bos taurus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]

Authors

Thomas Kelder , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

ketone bodies metabolic pathway ketone bodies biosynthetic pathway ketone bodies degradation pathway

Participants

Label Type Compact URI Comment
Acetyl-CoA Metabolite cas:72-89-9
Acetoacetyl-CoA Metabolite cas:1420-36-6
3-Hydroxy-3-methylglutaryl-CoA Metabolite cas:1553-55-5
3-Hydroxy-butyrate Metabolite pubchem.compound:441
Acetoacetate Metabolite pubchem.compound:6971017
ACAT1 GeneProduct ensembl:ENSBTAG00000012885 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:38
HMGCS2 GeneProduct ensembl:ENSBTAG00000003898 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3158
HMGCL GeneProduct ensembl:ENSBTAG00000021832 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3155
OXCT1 GeneProduct ensembl:ENSBTAG00000033186 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5019
BDH1 GeneProduct ensembl:ENSBTAG00000000448 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:622

References

  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia