Sulfide oxidation pathway (WP2235)
Caenorhabditis elegans
"Proposed mechanism. Both H2S and HCN can inhibit electron transport. Electron transport inhibition causes induction of HIF-1 activity resulting in high expression of SQRD-1 and CYSL-2. SQRD-1 catalyzes the first step in the H2S-oxidation pathway, ultimately resulting in production of sulfate and thiosulfate. CYSL-2 catalyzes the first step in the HCN assimilation pathway, producing H2S. The resultant H2S is detoxified by CYSL-1."
Authors
Karen Yook , Ulas Babayigit , and Egon WillighagenActivity
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Organisms
Caenorhabditis elegansCommunities
Annotations
Pathway Ontology
xenobiotics biodegradation pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| H2S | Metabolite | cas:7783-06-4 | |
| thiosulfate | Metabolite | hmdb:HMDB0000257 | |
| polysulfide | Metabolite | cas:9080-49-3 | |
| sulfate | Metabolite | hmdb:HMDB0001448 | |
| hydrogen cyanide | Metabolite | cas:74-90-8 | |
| cysteine | Metabolite | cas:52-90-4 | |
| hydrogen cyanide | Metabolite | hmdb:HMDB0002084 | |
| beta-cyanoalanine | Metabolite | cas:923-01-3 | |
| O-Acetylserine | Metabolite | cas:4985-36-8 | |
| acetate | Metabolite | cas:71-50-1 | |
| ETHE-1 | GeneProduct | wormbase:C33A12.7 | |
| CYSL-2 | GeneProduct | ensembl:WBGene00010759 | |
| HIF-1 | GeneProduct | ensembl:WBGene00001851 | |
| SQRD-1 | GeneProduct | ensembl:WBGene00008538 | |
| CYSL-1 | GeneProduct | ensembl:WBGene00007653 |
References
- The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide. Budde MW, Roth MB. Genetics. 2011 Oct;189(2):521–32. PubMed Europe PMC Scholia