Inflammatory response pathway (WP453)
Homo sapiens
Inflammation is a protective response of cells to pathogens, infection or tissue damage. It involves the coordinated communication of different immune cells and blood vessels through an intricate cascade of molecular signals. Inflammation can cause fever, cardiovascular pathology, allergy anaphylaxis, fibrosis, autoimmunity, etc. The inflammatory response has four phases: inflammatory inducers (infection or tissue damage), inflammatory sensors (mast cells and macrophages), inflammatory mediators (cytokines, chemokines, etc.) and the tissues that are affected. Each phase has many options that are triggered based on the type pathogen introduced. In addition, chronic inflammatory conditions, where an inducer is not well defined, are becoming more common. These conditions are of particular interest because they coincide with other diseases such as obesity, type 2 diabetes, atherosclerosis, neurodegenerative diseases and cancer. [http://www.thermofisher.com/ls/en/home/life-science/cell-analysis/signaling-pathways/inflammatory-response-pathway.html#] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP453 CPTAC Assay Portal]
Authors
Nick Fidelman , Kristina Hanspers , Zahra Roudbari , Denise Slenter , and Eric WeitzActivity
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Cited In
- An NF-κB- and Therapy-Related Regulatory Network in Glioma: A Potential Mechanism of Action for Natural Antiglioma Agents (2022).
- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- PODNL1 Methylation Serves as a Prognostic Biomarker and Associates with Immune Cell Infiltration and Immune Checkpoint Blockade Response in Lower-Grade Glioma (2021).
- Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients (2021).
- CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors (2020).
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
epithelial cell B cell fibroblast CD4-positive helper T cellPathway Ontology
inflammatory response pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IGHA2 | GeneProduct | ensembl:ENSG00000211890 | |
| IGHA1 | GeneProduct | ensembl:ENSG00000211895 | |
| CD86 | GeneProduct | ncbigene:942 | |
| TNFRSF1B | GeneProduct | ncbigene:7133 | |
| LAMB2 | GeneProduct | ncbigene:3913 | |
| IFNG | GeneProduct | ncbigene:3458 | |
| IGHM | GeneProduct | ncbigene:3507 | |
| THBS3 | GeneProduct | ncbigene:7059 | |
| VTN | GeneProduct | ncbigene:7448 | |
| IL2 | GeneProduct | ncbigene:3558 | |
| IL4R | GeneProduct | ncbigene:3566 | |
| IL2RB | GeneProduct | ncbigene:3560 | |
| LCK | GeneProduct | ncbigene:3932 | |
| LAMB1 | GeneProduct | ncbigene:3912 | |
| IL2RG | GeneProduct | ncbigene:3561 | |
| IL4 | GeneProduct | ncbigene:3565 | |
| COL3A1 | GeneProduct | ncbigene:1281 | |
| CD40 | GeneProduct | ncbigene:958 | |
| COL1A1 | GeneProduct | ncbigene:1277 | |
| LAMC2 | GeneProduct | ncbigene:3918 | |
| COL1A2 | GeneProduct | ncbigene:1278 | |
| CD28 | GeneProduct | ncbigene:940 | |
| CD40LG | GeneProduct | ncbigene:959 | |
| TNFRSF1A | GeneProduct | ncbigene:7132 | |
| FN1 | GeneProduct | ncbigene:2335 | |
| CD80 | GeneProduct | ncbigene:941 | |
| IL2RA | GeneProduct | ncbigene:3559 | |
| LAMC1 | GeneProduct | ncbigene:3915 | |
| ZAP70 | GeneProduct | ncbigene:7535 | |
| LAMA5 | GeneProduct | ncbigene:3911 | |
| THBS1 | GeneProduct | ncbigene:7057 | |
| IL5 | GeneProduct | ncbigene:3567 | |
| IL5RA | GeneProduct | ncbigene:3568 |
References
- Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. Monahan J, Siegel N, Keith R, Caparon M, Christine L, Compton R, et al. J Immunol. 1997 Oct 15;159(8):4024–34. PubMed Europe PMC Scholia
- Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay. Greisenegger S, Zehetmayer S, Bauer P, Endler G, Ferrari J, Lang W, et al. Clin Chem. 2009 Jan;55(1):134–8. PubMed Europe PMC Scholia