Type II interferon signaling (WP619)

Homo sapiens

Authors

Thomas Kelder , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Cited In

• DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
• Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
• Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients (2021).
• A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection (2020).
• LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC (2020).
• Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia (2019).
• Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification (2016).
• Prolactin Receptor in Primary Hyperparathyroidism – Expression, Functionality and Clinical Correlations (2012).
• Proteomic Consequences of a Single Gene Mutation in a Colorectal Cancer Model (2011).
• Discovering Common Pathogenic Mechanisms of COVID-19 and Parkinson Disease: An Integrated Bioinformatics Analysis (2022).
• Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
• Construction and analysis of protein-protein interaction network of non-alcoholic fatty liver disease.
• In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
• Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 (2022).
• Statistical and network analyses reveal mechanisms for the enhancement of macrophage immunity by manganese in Mycobacterium tuberculosis infection (2024).
• Transcriptional Profiling of SARS-CoV-2-Infected Calu-3 Cells Reveals Immune-Related Signaling Pathways (2024).
• Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).

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Organisms

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology

Jak-Stat signaling pathway type II interferon signaling pathway

References

1. A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia