Kennedy pathway from sphingolipids (WP3933)
Homo sapiens
The CDP-choline pathway, first identified by Eugene Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway on the left-hand side represents one half of what is known as the Kennedy pathway. The other half on the right-hand side is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid product phosphatidylethanolamine (PE). Source: Wikipedia.
Authors
Kristina Hanspers , Denise Slenter , Egon Willighagen , Eric Weitz , and Lars WillighagenActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
lipid metabolic pathway CDP-choline pathway of phosphatidylcholine biosynthesis CDP-choline pathway of phosphatidylcholine biosynthesis phospholipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ethanolamine | Metabolite | kegg.compound:C00189 | |
| SAM | Metabolite | kegg.compound:C00019 | |
| PPi | Metabolite | wikidata:Q290828 | PPi=pyrophosphate |
| Phosphocholine | Metabolite | chebi:18132 | |
| Sphingolipid | Metabolite | chebi:26739 |
References
- The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. Gibellini F, Smith TK. IUBMB Life. 2010 Jun;62(6):414–28. PubMed Europe PMC Scholia
- Genetic diseases of the Kennedy pathways for membrane synthesis. Tavasoli M, Lahire S, Reid T, Brodovsky M, McMaster CR. J Biol Chem. 2020 Dec 18;295(51):17877–86. PubMed Europe PMC Scholia