Thiamine metabolic pathways (WP4297)

Homo sapiens

Thiamine is absorbed in the form of thiamine or thiamine monophosphate and transported through the plasma membrane by thiamine transporter 1 (THTR1) and thiamine transporter 2 (THTR2), which are encoded for by the genes SLC19A2 and SLC19A3, respectively. Upon cell entrance, thiamine undergoes pyrophosphorylation by thiamine pyrophosphokinase (TPK) to thiamine pyrophosphate (TPP). TPP is the active form of thiamine and serves as a cofactor of transketolase in the pentose phosphate pathway in the cytosol. TPP also functions as a cofactor for pyruvate, ketoglutarate and branched chain alpha-keto acid dehydrogenases in the mitochondrion after entrance via TPP transporter encoded by SLC25A19. This pathway was inspired by Chapter 15 (Thiamine Disorders) of the book of Blau (ISBN 3642403360 (978-3642403361)).

Authors

Youssef Walid , Egon Willighagen , Denise Slenter , Irene Hemel , Friederike Ehrhart , and Finterly Hu

Activity

last edited pathway curation

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Inherited Metabolic Disorders (IMD) Pathways Rare Diseases

Annotations

Pathway Ontology

energy metabolic pathway thiamine metabolic pathway

Participants

Label Type Compact URI Comment
Branched chain acylCoAs Metabolite chebi:61912
DNA Metabolite chebi:16991
Glucose 6-phosphate Metabolite hmdb:HMDB0001401
isocitrate Metabolite chebi:16087
Glucose 1-phosphate Metabolite hmdb:HMDB0001586
succinate Metabolite chebi:30031
DHAP Metabolite chebi:16108
Branched chain amino acids Metabolite chebi:22918
Glycerol 3-phosphate Metabolite hmdb:HMDB0000126
Oxaloacetate Metabolite chebi:30744
citrate Metabolite chebi:133748
pyruvate Metabolite chebi:15361
D-Glyceraldehyde 3-phosphate Metabolite hmdb:HMDB0001112
Thiamine pyrophosphate(TPP) Metabolite chebi:45931
serine Metabolite chebi:17822
Acetyl-CoA Metabolite chebi:15351
alpha-ketoglutarate Metabolite chebi:16810
D-Ribose 5-phosphate Metabolite hmdb:HMDB0001548
TPP Metabolite chebi:45931
sphingolipids Metabolite chebi:26739
phospholipids Metabolite chebi:16247
Thiamine monophosphate (TMP) Metabolite chebi:9533 Thiamine enters the cell via diffusion or transphosphorylation to thiamine monophosphate (TMP).
thiamine Metabolite chebi:33283
THTR1(SLC19A2) GeneProduct ensembl:ENSG00000117479
TKT GeneProduct ensembl:ENSG00000163931
THTR2(SLC19A3) GeneProduct ensembl:ENSG00000135917
SLC25A19 GeneProduct ensembl:ENSG00000125454
Pyruvate dehydrogenase E1 GeneProduct ensembl:ENSG00000131828
BCKDK GeneProduct ensembl:ENSG00000103507
OGDH GeneProduct ensembl:ENSG00000105953
TPK1 GeneProduct ensembl:ENSG00000196511
Branched chain keto acid dehydrogenase E1 Protein uniprot:A0A024R0K3

References

  1. Physician’s Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases [Internet]. Blau N, Duran M, Gibson KM, Dionisi-Vici C. Springer; 2014. 0 p. Available from: https://books.google.com/books/about/Physician_s_Guide_to_the_Diagnosis_Treat.html?hl=&id=wJRBnwEACAAJ OpenLibrary Worldcat
  2. Thiamine intestinal transport and related issues: recent aspects. Rindi G, Laforenza U. Proc Soc Exp Biol Med. 2000 Sep;224(4):246–55. PubMed Europe PMC Scholia