Ectoderm differentiation (WP2858)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2858 CPTAC Assay Portal]

Authors

Nathan Salomonis , Egon Willighagen , Zahra Roudbari , Kristina Hanspers , Friederike Ehrhart , Susan Coort , Martina Summer-Kutmon , Marvin Martens , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
TSKU GeneProduct ensembl:ENSG00000182704
SMAD4 GeneProduct ensembl:ENSG00000141646
PGM1 GeneProduct ensembl:ENSG00000079739
PLCXD3 GeneProduct ensembl:ENSG00000182836
CELSR2 GeneProduct ensembl:ENSG00000143126
PPFIBP2 GeneProduct ensembl:ENSG00000166387
FZD4 GeneProduct ensembl:ENSG00000174804
FZD8 GeneProduct ensembl:ENSG00000177283
ROR2 GeneProduct ensembl:ENSG00000169071
MIR34C GeneProduct ensembl:ENSG00000207562
ASTN1 GeneProduct ensembl:ENSG00000152092
LDB2 GeneProduct ncbigene:9079
CCL2 GeneProduct ensembl:ENSG00000108691
TNFRSF11B GeneProduct ensembl:ENSG00000164761
BCAS3 GeneProduct ensembl:ENSG00000141376
GAS2L1 GeneProduct ensembl:ENSG00000185340
PIM1 GeneProduct ncbigene:5292
ZBTB2 GeneProduct ncbigene:57621
CLVS1 GeneProduct ensembl:ENSG00000177182
BAZ1A GeneProduct ncbigene:11177
HIST1H2BH GeneProduct ncbigene:8345
ZNF219 GeneProduct ensembl:ENSG00000165804
GRAMD1B GeneProduct ensembl:ENSG00000023171
ANKS1B GeneProduct ensembl:ENSG00000185046
FOXL1 GeneProduct ensembl:ENSG00000176678
GATA6 GeneProduct ensembl:ENSG00000141448
UBTF GeneProduct ncbigene:7343
GREB1 GeneProduct ensembl:ENSG00000196208
DMD GeneProduct ensembl:ENSG00000198947
C1GALT1 GeneProduct ensembl:ENSG00000106392
KCNK10 GeneProduct ensembl:ENSG00000100433
NLK GeneProduct ensembl:ENSG00000087095
MECP2 GeneProduct ensembl:ENSG00000169057
MYC GeneProduct ncbigene:4609
ZFHX4 GeneProduct ensembl:ENSG00000091656
MIR361 GeneProduct ensembl:ENSG00000199051
RRBP1 GeneProduct ensembl:ENSG00000125844
WDR44 GeneProduct ensembl:ENSG00000131725
KIFC3 GeneProduct ensembl:ENSG00000140859
PTPRB GeneProduct ensembl:ENSG00000127329
NARS2 GeneProduct ensembl:ENSG00000137513
ARHGDIG GeneProduct ensembl:ENSG00000242173
POU2F2 GeneProduct ensembl:ENSG00000028277
PODXL GeneProduct ensembl:ENSG00000128567
CLDN11 GeneProduct ensembl:ENSG00000013297
ELOVL2 GeneProduct ensembl:ENSG00000197977
SKIL GeneProduct ncbigene:6498
SORCS1 GeneProduct ensembl:ENSG00000108018
PRKAG2 GeneProduct ensembl:ENSG00000106617
PHF8 GeneProduct ensembl:ENSG00000172943
SPRY2 GeneProduct ensembl:ENSG00000136158
TRIM33 GeneProduct ensembl:ENSG00000197323
RHPN1 GeneProduct ensembl:ENSG00000158106
FZD5 GeneProduct ensembl:ENSG00000163251
PLXNA2 GeneProduct ensembl:ENSG00000076356
STC1 GeneProduct ensembl:ENSG00000159167
JAKMIP1 GeneProduct ensembl:ENSG00000152969
MZF1 GeneProduct ensembl:ENSG00000099326
LY6E GeneProduct ensembl:ENSG00000160932
ST8SIA4 GeneProduct ensembl:ENSG00000113532
SERPINB6 GeneProduct ensembl:ENSG00000124570
AES GeneProduct ensembl:ENSG00000104964
NFATC1 GeneProduct ensembl:ENSG00000131196
GLB1 GeneProduct ensembl:ENSG00000170266
PI4KA GeneProduct ensembl:ENSG00000241973
EDA GeneProduct ensembl:ENSG00000158813
ARX GeneProduct ensembl:ENSG00000004848
RGMA GeneProduct ensembl:ENSG00000182175
TRPM2 GeneProduct ensembl:ENSG00000142185
MIR15B GeneProduct ensembl:ENSG00000207779
KIAA1161 GeneProduct ensembl:ENSG00000164976
STX16 GeneProduct ensembl:ENSG00000124222
CROCCP2 GeneProduct ensembl:ENSG00000215908
ELOVL4 GeneProduct ensembl:ENSG00000118402
TOX3 GeneProduct ensembl:ENSG00000103460
CAP2 GeneProduct ensembl:ENSG00000112186
SOCS2 GeneProduct ensembl:ENSG00000120833
ABCC4 GeneProduct ensembl:ENSG00000125257
SCHIP1 GeneProduct ensembl:ENSG00000151967
PPARD GeneProduct ensembl:ENSG00000112033
FOXA2 GeneProduct ensembl:ENSG00000125798
SNCA GeneProduct ensembl:ENSG00000145335
PAX6 GeneProduct ensembl:ENSG00000007372
PAX3 GeneProduct ensembl:ENSG00000135903
ARHGAP15 GeneProduct ensembl:ENSG00000075884
GLI3 GeneProduct ensembl:ENSG00000106571
SHH GeneProduct ensembl:ENSG00000164690
CTNNB1 GeneProduct ensembl:ENSG00000168036
WNT1 GeneProduct ensembl:ENSG00000125084
OGT GeneProduct ensembl:ENSG00000147162
NR2F2 GeneProduct ensembl:ENSG00000185551
BOC GeneProduct ensembl:ENSG00000144857
PAN2 GeneProduct ensembl:ENSG00000135473
CTBP1 GeneProduct ensembl:ENSG00000159692
CCDC88C GeneProduct ensembl:ENSG00000015133
HDAC10 GeneProduct ensembl:ENSG00000100429
VAX2 GeneProduct ensembl:ENSG00000116035
ARHGEF9 GeneProduct ensembl:ENSG00000131089
CTNNA2 GeneProduct ensembl:ENSG00000066032
JUP GeneProduct ensembl:ENSG00000173801
MKS1 GeneProduct ensembl:ENSG00000011143
CCDC130 GeneProduct ensembl:ENSG00000104957
SGSM3 GeneProduct ensembl:ENSG00000100359
SDCBP GeneProduct ensembl:ENSG00000137575
FGFR2 GeneProduct ensembl:ENSG00000066468
KRT6A GeneProduct ensembl:ENSG00000205420
HMGB2 GeneProduct ensembl:ENSG00000164104
CTNND2 GeneProduct ensembl:ENSG00000169862
ZBTB16 GeneProduct ensembl:ENSG00000109906
CDH6 GeneProduct ensembl:ENSG00000113361
TSC22D1 GeneProduct ensembl:ENSG00000102804
CDH8 GeneProduct ensembl:ENSG00000150394
NUMA1 GeneProduct ensembl:ENSG00000137497
LHX1 GeneProduct ensembl:ENSG00000273706
TCF3 GeneProduct ensembl:ENSG00000071564
ZBTB7B GeneProduct ensembl:ENSG00000160685
TTC14 GeneProduct ensembl:ENSG00000163728
RAB8B GeneProduct ensembl:ENSG00000166128
NF2 GeneProduct ensembl:ENSG00000186575
NLGN1 GeneProduct ensembl:ENSG00000169760
EDA2R GeneProduct ensembl:ENSG00000131080
PTPN13 GeneProduct ensembl:ENSG00000163629
AHI1 GeneProduct ensembl:ENSG00000135541
FYN GeneProduct ensembl:ENSG00000010810
PDE7A GeneProduct ensembl:ENSG00000205268
CDON GeneProduct ensembl:ENSG00000064309
RIT1 GeneProduct ensembl:ENSG00000143622
SMURF1 GeneProduct ensembl:ENSG00000198742
TBL1X GeneProduct ensembl:ENSG00000101849
HDAC6 GeneProduct ensembl:ENSG00000094631
BMP4 GeneProduct ensembl:ENSG00000125378
BMPR1A GeneProduct ensembl:ENSG00000107779
TCF7L1 GeneProduct ensembl:ENSG00000152284
HESX1 GeneProduct ensembl:ENSG00000163666
SIX6 GeneProduct ensembl:ENSG00000184302
ARHGAP10 GeneProduct ensembl:ENSG00000071205
MAFB GeneProduct ensembl:ENSG00000204103
TFAP2C GeneProduct ensembl:ENSG00000087510
SOX2 GeneProduct ensembl:ENSG00000181449
TFAP2A GeneProduct ensembl:ENSG00000137203
FHL2 GeneProduct ncbigene:2274
BCOR GeneProduct ncbigene:54880

References

  1. Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development. Van Hateren N, Shenton T, Borycki AG. Dev Dyn. 2006 Feb;235(2):490–5. PubMed Europe PMC Scholia
  2. Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway. Alexandrova EM, Thomsen GH. Dev Biol. 2006 Nov 15;299(2):398–410. PubMed Europe PMC Scholia
  3. Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. Smith AN, Miller LA, Radice G, Ashery-Padan R, Lang RA. Development. 2009 Sep;136(17):2977–85. PubMed Europe PMC Scholia
  4. Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. Meyn MA 3rd, Smithgall TE. Sci Signal. 2009 Oct 13;2(92):ra64. PubMed Europe PMC Scholia
  5. HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain. Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, et al. Development. 2011 Nov;138(22):4931–42. PubMed Europe PMC Scholia
  6. Beyond cell adhesion: the role of armadillo proteins in the heart. Swope D, Li J, Radice GL. Cell Signal. 2013 Jan;25(1):93–100. PubMed Europe PMC Scholia
  7. Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development. Mukhopadhyay A, Krishnaswami SR, Cowing-Zitron C, Hung NJ, Reilly-Rhoten H, Burns J, et al. Dev Biol. 2013 Jan 15;373(2):373–82. PubMed Europe PMC Scholia
  8. Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells. Leung AW, Kent Morest D, Li JYH. Dev Biol. 2013 Jul 15;379(2):208–20. PubMed Europe PMC Scholia
  9. Hedgehog and Gli signaling in embryonic mammary gland development. Lee MY, Sun L, Veltmaat JM. J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):133–8. PubMed Europe PMC Scholia