STING pathway in Kawasaki-like disease and COVID-19 (WP4961)
Homo sapiens
Triggering of the STING pathway by foreign DNA or damaged mitochondrial DNA can activate multiple downstream responses. The STING pathway is relevant to Kawasaki-like disease in COVID-19.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Eric Weitz , and Martina Summer-KutmonActivity
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Cited In
- Identification of host genomic biomarkers from multiple transcriptomics datasets for diagnosis and therapies of SARS-CoV-2 infections (2023).
- Transcriptional Profiling of SARS-CoV-2-Infected Calu-3 Cells Reveals Immune-Related Signaling Pathways (2024).
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
pattern recognition receptor mediated signaling pathway acetylsalicylic acid drug pathway disease pathway vitamin D signaling pathwayDisease Ontology
Kawasaki disease COVID-19| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Angiotensin II | Metabolite | chebi:2719 | |
| Aspirin | Metabolite | chebi:15365 | |
| Vitamin D3 | Metabolite | chebi:28940 | |
| cGAMP | Metabolite | chebi:71580 | |
| Cytokines | GeneProduct | wikidata:Q212354 | |
| Cytosolic DNA(viral DNA and damaged mtDNA) | GeneProduct | wikidata:Q7430 | |
| F3 | GeneProduct | ensembl:ENSG00000117525 | |
| CHUK | GeneProduct | ensembl:ENSG00000213341 | |
| IKBKE | GeneProduct | ensembl:ENSG00000263528 | |
| IL1B | GeneProduct | ensembl:ENSG00000125538 | |
| GSDMD | GeneProduct | ensembl:ENSG00000104518 | |
| IFNB1 | GeneProduct | ensembl:ENSG00000171855 | |
| ITPR1 | GeneProduct | ensembl:ENSG00000150995 | |
| FCGR2A | GeneProduct | ensembl:ENSG00000143226 | |
| NLRP3 | GeneProduct | ensembl:ENSG00000162711 | |
| TBK1 | GeneProduct | ensembl:ENSG00000183735 | |
| NLRX1 | GeneProduct | ensembl:ENSG00000160703 | |
| STING1 | GeneProduct | ensembl:ENSG00000184584 | |
| IRF3 | GeneProduct | ensembl:ENSG00000126456 | |
| CGAS | GeneProduct | ensembl:ENSG00000164430 | |
| IKBKB | GeneProduct | ensembl:ENSG00000104365 | |
| IKBKG | GeneProduct | ensembl:ENSG00000269335 | NEMO |
| RELA | GeneProduct | ensembl:ENSG00000173039 | RelA |
| NFKBIA | GeneProduct | ensembl:ENSG00000100906 | |
| REL | GeneProduct | ensembl:ENSG00000162924 | c-Rel |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | |
| NFKBIE | GeneProduct | ensembl:ENSG00000146232 |
References
- Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway? Berthelot JM, Drouet L, Lioté F. Emerg Microbes Infect. 2020 Dec;9(1):1514–22. PubMed Europe PMC Scholia