Cardiomyocyte signaling converging on titin (WP5344)
Homo sapiens
Involvement of titin in cardiomyocyte signaling pathways and its effect on protein quality control pathways as well as hypertrophic signaling within a cardiomyocyte.
Authors
Beppie , Isa Leenders , Sena , Javier Millán Acosta , Egon Willighagen , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathway Ras superfamily mediated signaling pathwayCell Type Ontology
cardiac muscle cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca2+ | Metabolite | chebi:29108 | |
| GTP(4 - ) | Metabolite | chebi:37565 | |
| NO | Metabolite | chebi:16480 | |
| 3',5'-cyclic GMP | Metabolite | chebi:16356 | |
| 3',5'-cyclic AMP | Metabolite | chebi:17489 | |
| ATP | Metabolite | chebi:30616 | |
| TTN | GeneProduct | ensembl:ENSG00000155657 | |
| NPR1 | GeneProduct | uniprot:P16066 | |
| PRKAR1A | GeneProduct | ensembl:ENSG00000108946 | |
| ANKRD23 | GeneProduct | ensembl:ENSG00000163126 | |
| GUCD1 | GeneProduct | ensembl:ENSG00000138867 | |
| FHL1 | GeneProduct | uniprot:Q13642 | |
| SRF | GeneProduct | uniprot:P11831 | |
| ANKRD1 | GeneProduct | ensembl:ENSG00000148677 | |
| GUCY1B1 | GeneProduct | ensembl:ENSG00000061918 | |
| TCAP | GeneProduct | ensembl:ENSG00000173991 | |
| PRKACB | GeneProduct | ensembl:ENSG00000142875 | |
| MAPK1 | GeneProduct | ensembl:ENSG00000100030 | |
| PRKACA | GeneProduct | uniprot:P17612 | |
| MYPN | GeneProduct | ensembl:ENSG00000138347 | |
| PRKCA | GeneProduct | ensembl:ENSG00000154229 | |
| RAS | GeneProduct | uniprot:P01114 | |
| CSRP3 | GeneProduct | ensembl:ENSG00000129170 | |
| CAMK2A | GeneProduct | ensembl:ENSG00000070808 | |
| PRKACG | GeneProduct | ensembl:ENSG00000165059 | |
| ANKRD2 | GeneProduct | ensembl:ENSG00000165887 | |
| PRKG2 | GeneProduct | uniprot:Q13237 | |
| TRIM55 | GeneProduct | uniprot:Q9BYV6 | |
| NBR1 | GeneProduct | uniprot:Q14596 | |
| Capn1 | GeneProduct | uniprot:Q3TB79 | |
| CRYAB | GeneProduct | uniprot:P02511 | |
| NUP62 | GeneProduct | uniprot:P37198 | |
| TRIM63 | GeneProduct | uniprot:Q969Q1 | |
| FHL2 | GeneProduct | uniprot:Q14192 | |
| MDM2 | GeneProduct | uniprot:Q00987 | |
| MAP2K1 | GeneProduct | uniprot:Q02750 | |
| MAP2K2 | GeneProduct | uniprot:P36507 | |
| RAF1 | GeneProduct | uniprot:P04049 | |
| GPCR | GeneProduct | uniprot:Q8TDU1 | |
| PLCZ1 | GeneProduct | ensembl:ENSG00000139151 | |
| ADRB2 | GeneProduct | uniprot:P07550 | |
| ADRB1 | GeneProduct | uniprot:P08588 | |
| Adenylyl cyclase | GeneProduct | uniprot:Q59FG4 |
References
- The giant protein titin: a regulatory node that integrates myocyte signaling pathways. Krüger M, Linke WA. J Biol Chem. 2011 Mar 25;286(12):9905–12. PubMed Europe PMC Scholia
- Gigantic business: titin properties and function through thick and thin. Linke WA, Hamdani N. Circ Res. 2014 Mar 14;114(6):1052–68. PubMed Europe PMC Scholia