Energy metabolism (WP1541)

Homo sapiens

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"The PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity." Description source: Wikipedia ([[wikipedia:PPARGC1A]]) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1541 CPTAC Assay Portal]

Authors

Madeline Kosho , Alex Pico , Jildau Bouwman , Kristina Hanspers , Egon Willighagen , Denise Slenter , Marvin Martens , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

energy metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Acetyl Metabolite chebi:40574 Changed ID to acetyl leaving group.
PPARG GeneProduct ncbigene:5468
TFAM GeneProduct ncbigene:7019
PPP3CA GeneProduct ncbigene:5530
PPARGC1A GeneProduct ncbigene:10891
PPARA GeneProduct ncbigene:5465
PPP3R1 GeneProduct ncbigene:5534
PPP3CB GeneProduct ncbigene:5532
PRKAG3 GeneProduct ncbigene:53632
EP300 GeneProduct ncbigene:2033
GSK3B GeneProduct ncbigene:2932
PRKAB1 GeneProduct ncbigene:5564
RXRA GeneProduct ncbigene:6256
PPARD GeneProduct ncbigene:5467
TFB1M GeneProduct ncbigene:51106
MEF2D GeneProduct ncbigene:4209
CREB1 GeneProduct ncbigene:1385
PRKAB2 GeneProduct ncbigene:5565
TFB2M GeneProduct ncbigene:64216
UCP2 GeneProduct ncbigene:7351
NRF1 GeneProduct ncbigene:4899
PRKAA1 GeneProduct ncbigene:5562
MAPK14 GeneProduct ncbigene:1432
MEF2A GeneProduct ncbigene:4205
FOXO1 GeneProduct ncbigene:2308
GABPA GeneProduct ncbigene:2551
HDAC1 GeneProduct ncbigene:3065
MEF2B GeneProduct ncbigene:100271849
ESRRA GeneProduct ncbigene:2101
MYBBP1A GeneProduct ncbigene:10514
FOXO3 GeneProduct ncbigene:2309
PRKAG1 GeneProduct ncbigene:5571
ATF2 GeneProduct ncbigene:1386
CAMK4 GeneProduct ncbigene:814
MEF2C GeneProduct ncbigene:4208
PPRC1 GeneProduct ncbigene:23082
MED1 GeneProduct ncbigene:5469
PPP3CC GeneProduct ncbigene:5533
SIRT1 GeneProduct ncbigene:23411
UCP3 GeneProduct ncbigene:7352
PPARGC1B GeneProduct ncbigene:133522
CAMK2G GeneProduct ncbigene:818
PRMT1 GeneProduct ncbigene:3276
SIRT3 GeneProduct ncbigene:23410
PRKAG2 GeneProduct ncbigene:51422
PPP3R2 GeneProduct ncbigene:5535
PRKAA2 GeneProduct ncbigene:5563
NCOA1 GeneProduct ncbigene:8648

References