Sildenafil treatment (WP5294)
Homo sapiens
Sildenafil treatment
Authors
Cenna Doornbos , Egon Willighagen , Denise Slenter , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
mitochondrial disease pathwayDisease Ontology
pulmonary hypertension impotence hypertensionLabel | Type | Compact URI | Comment |
---|---|---|---|
cGMP | Metabolite | chebi:16356 | |
Nitric oxide | Metabolite | chebi:16480 | |
AMP | Metabolite | chebi:16027 | |
GTP | Metabolite | chebi:37565 | |
GAPDH inhibitors | Metabolite | chebi:70817 | |
GMP | Metabolite | chebi:17345 | |
Tideglusib | Metabolite | chebi:147398 | |
Sildenafil | Metabolite | chebi:9139 | |
PDE4inhibitors | Metabolite | chebi:68844 | |
AKT1 | GeneProduct | ensembl:ENSG00000142208 | |
TFAM | GeneProduct | ensembl:ENSG00000108064 | |
PRKG1 | GeneProduct | ensembl:ENSG00000185532 | |
PRKN | GeneProduct | ensembl:ENSG00000185345 | |
AKT2 | GeneProduct | ensembl:ENSG00000105221 | |
ZNF746 | GeneProduct | ensembl:ENSG00000181220 | |
NRF1 | GeneProduct | ensembl:ENSG00000106459 | |
GUCY1A2 | GeneProduct | ensembl:ENSG00000152402 | |
GAPDH | GeneProduct | ensembl:ENSG00000111640 | |
PDE5 | GeneProduct | ensembl:ENSG00000138735 | Inhibition of cGMP degradation by PDE5 increases cGMP availability [PMID:9714779]. |
PDE4A | GeneProduct | ensembl:ENSG00000065989 | |
PDE4D | GeneProduct | ensembl:ENSG00000113448 | |
GSK3B | GeneProduct | ensembl:ENSG00000082701 | |
PPARGC1A | GeneProduct | ensembl:ENSG00000109819 | Alternative name is PGC1A [uniprot:Q9UBK2] |
PDE4C | GeneProduct | ensembl:ENSG00000105650 | |
NOS1 | GeneProduct | ensembl:ENSG00000089250 | |
PDE4B | GeneProduct | ensembl:ENSG00000184588 | |
GUCY1B2 | GeneProduct | ensembl:ENSG00000123201 | |
GUCY1A1 | GeneProduct | ensembl:ENSG00000164116 | Also known as GUCY1A3 [uniprot:Q02108]. |
GUCY1B1 | GeneProduct | ensembl:ENSG00000061918 | Also known as GUCY1B3 [uniprot:Q02153]. |
AKT3 | GeneProduct | ensembl:ENSG00000117020 | |
NOS3 | GeneProduct | ensembl:ENSG00000164867 | NOS3 is implicated in vascular smooth muscle relaxation through cGMP [PMID:1378832,PMID:20590592]. |
NOS2 | GeneProduct | ensembl:ENSG00000007171 |
References
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