Statin pathway (WP1)
Mus musculus
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/pathway/PA2031 PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]
Authors
Nathan Salomonis , Kristina Hanspers , Bruce Conklin , Alex Pico , Thomas Kelder , Martina Summer-Kutmon , Andra Waagmeester , Egon Willighagen , Daniela Digles , and Eric WeitzActivity
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Cited In
- Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats (2016).
- Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone (2016).
- Automatically visualise and analyse data on pathways using PathVisioRPC from any programming environment (2015).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
statin drug pathway hypercholesterolemia pathwayDisease Ontology
cardiovascular system diseaseCell Type Ontology
hepatocyte| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Triglycerides | Metabolite | chebi:17855 | |
| Phospholipid | Metabolite | chebi:16247 | |
| Fatty acid | Metabolite | chebi:35366 | |
| Cholesterol ester | Metabolite | chebi:17002 | |
| Cholesterol | Metabolite | hmdb:HMDB0000067 | |
| Statin | Metabolite | chebi:87631 | |
| Cholic acid | Metabolite | hmdb:HMDB0000619 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| Lrp1 | GeneProduct | ncbigene:16971 | |
| Apoc3 | GeneProduct | ncbigene:11814 | |
| Apoc2 | GeneProduct | ncbigene:11813 | |
| Lipc | GeneProduct | ncbigene:15450 | |
| Cetp | GeneProduct | ncbigene:1071 | |
| Apoa4 | GeneProduct | ncbigene:11808 | |
| Dgat1 | GeneProduct | ncbigene:13350 | |
| Lpl | GeneProduct | ncbigene:16956 | |
| Scarb1 | GeneProduct | ncbigene:20778 | |
| Pltp | GeneProduct | ncbigene:18830 | |
| Ldlr | GeneProduct | ncbigene:16835 | |
| Abca1 | GeneProduct | ncbigene:11303 | |
| Cyp7a1 | GeneProduct | ncbigene:13122 | |
| Hmgcr | GeneProduct | ncbigene:15357 | |
| Apoa1 | GeneProduct | ncbigene:11806 | |
| Soat1 | GeneProduct | ncbigene:20652 | |
| Lcat | GeneProduct | ncbigene:16816 | |
| Mttp | GeneProduct | ncbigene:17777 | |
| Apoc1 | GeneProduct | ncbigene:11812 | |
| Apoe | GeneProduct | ncbigene:11816 |
References
- Direct effects of statins on cells primarily involved in atherosclerosis. Chen H, Ikeda U, Shimpo M, Shimada K. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia