HDAC6 interactions in the central nervous system (WP5426)

Homo sapiens

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HDAC6 stands out as a distinctive member within the histone deacetylase family due to its predominant presence in the cytosol, facilitating its interaction with a wide array of non-histone proteins. Its dysregulation has been linked to various outcomes, encompassing diverse cancer types, immune-related disorders, and neurological conditions, including Alzheimer's, Parkinson's, ALS, Huntington's, Charcot-Marie-Tooth disease, and Rett syndrome. The current network represents the known HDAC6 interactions in the central nervous system (CNS).

Authors

Nasim Bahram Sangani , Alex Pico , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway pertinent to the brain

Participants
Query Drugst.One

Label Type Compact URI Comment
MYH9 GeneProduct ensembl:ENSG00000100345
TUBA4A GeneProduct ensembl:ENSG00000127824
BIRC5 GeneProduct ensembl:ENSG00000089685
VCP GeneProduct ensembl:ENSG00000165280
tat GeneProduct ncbigene:155871
GSK3A GeneProduct ensembl:ENSG00000105723
NR3C1 GeneProduct ensembl:ENSG00000113580
MYD88 GeneProduct ensembl:ENSG00000172936
HSPA8 GeneProduct ensembl:ENSG00000109971
KALRN GeneProduct ensembl:ENSG00000160145
SEPTIN7 GeneProduct ensembl:ENSG00000122545 
POU5F1 GeneProduct ensembl:ENSG00000204531
OPTN GeneProduct ensembl:ENSG00000123240
PARK7 GeneProduct ensembl:ENSG00000116288
MAPRE1 GeneProduct ensembl:ENSG00000101367
MIIP GeneProduct ensembl:ENSG00000116691
ACTR1A GeneProduct ensembl:ENSG00000138107
PXN GeneProduct ensembl:ENSG00000089159
TWIST1 GeneProduct ensembl:ENSG00000122691
CYBB GeneProduct ensembl:ENSG00000165168
STUB1 GeneProduct ensembl:ENSG00000103266
ATXN3 GeneProduct ensembl:ENSG00000066427 Burnett et al. also found that ataxin-3 interacts with HDAC6 and dynein motor
HDAC6 GeneProduct ensembl:ENSG00000094631
BDNF GeneProduct ensembl:ENSG00000176697
APOE GeneProduct ensembl:ENSG00000130203
BBIP1 GeneProduct ensembl:ENSG00000214413
MAPT GeneProduct ensembl:ENSG00000186868
HDAC11 GeneProduct ensembl:ENSG00000163517
ERG GeneProduct ensembl:ENSG00000157554
HDAC9 GeneProduct ensembl:ENSG00000048052
SQSTM1 GeneProduct ensembl:ENSG00000161011
TRIM50 None
UBD GeneProduct ensembl:ENSG00000213886
G3BP1 GeneProduct ensembl:ENSG00000145907
TPPP GeneProduct ensembl:ENSG00000171368
PRKCE GeneProduct ensembl:ENSG00000171132
SMAD2 GeneProduct ensembl:ENSG00000175387
PROM1 GeneProduct ensembl:ENSG00000007062
RAD23B GeneProduct ensembl:ENSG00000119318
AKT1 GeneProduct ensembl:ENSG00000142208
CFTR GeneProduct ensembl:ENSG00000001626
ISG15 GeneProduct ensembl:ENSG00000187608
EP300 GeneProduct ensembl:ENSG00000100393
SOD1 GeneProduct ensembl:ENSG00000142168
GRK2 GeneProduct ensembl:ENSG00000173020
GSK3B GeneProduct ensembl:ENSG00000082701 GSK3b was found to co-localize with HDAC6 in hippocampal neurons, and inhibition of GSK3b resulted in decreased binding of antibody to phosphoserine-22, a potential GSK3b phosphorylation site in HDAC6.. We also provide evidence that GSK3b may directly regulate HDAC6.
PRKCZ GeneProduct ensembl:ENSG00000067606
EGFR GeneProduct ensembl:ENSG00000146648
AURKA GeneProduct ensembl:ENSG00000087586 AurA phosphorylates HDAC6 to activate
MAPK3 GeneProduct ensembl:ENSG00000102882
MAPK1 GeneProduct ensembl:ENSG00000100030
SIRT2 GeneProduct ensembl:ENSG00000068903
CDC20 GeneProduct ensembl:ENSG00000117399
HSP90AA1 GeneProduct ensembl:ENSG00000080824
HSF1 GeneProduct ensembl:ENSG00000185122
CTNNB1 GeneProduct ensembl:ENSG00000168036
ELP1 GeneProduct ensembl:ENSG00000070061
MAPK8 GeneProduct ensembl:ENSG00000107643
EP400 GeneProduct ensembl:ENSG00000183495
KAT5 GeneProduct ensembl:ENSG00000172977
APC GeneProduct ensembl:ENSG00000134982
RAC1 GeneProduct ensembl:ENSG00000136238
DLG4 GeneProduct ensembl:ENSG00000132535
DLG2 GeneProduct ensembl:ENSG00000150672
SNCAIP GeneProduct ensembl:ENSG00000064692
HTT GeneProduct ensembl:ENSG00000197386
ELP3 GeneProduct ensembl:ENSG00000134014
PPP1CA GeneProduct ensembl:ENSG00000172531
SGK3 GeneProduct ensembl:ENSG00000104205
SGK1 GeneProduct ensembl:ENSG00000118515
MAP1LC3A GeneProduct ensembl:ENSG00000101460
NEDD9 GeneProduct ensembl:ENSG00000111859
CSNK2B GeneProduct ensembl:ENSG00000204435 To verify the association of HDAC6 with CK2, we performed a pull-down assay using two recombinant proteins (GST–HDAC6 and CK2 holoenzyme) and individual subunit proteins (Fig. 2C, top). Only CK2 holoenzyme was found to be associated with HDAC6, whereas CK2α and CK2β alone failed to precipitate with HDAC6, indicating that the CK2 holoenzyme associates with HDAC6
DCTN1 GeneProduct ensembl:ENSG00000204843
GRIA2 GeneProduct ensembl:ENSG00000120251
GRIA1 GeneProduct ensembl:ENSG00000155511
TARDBP GeneProduct ensembl:ENSG00000120948
FUS GeneProduct ensembl:ENSG00000089280
DYNC1I2 GeneProduct ensembl:ENSG00000077380
CSNK2A2 GeneProduct ensembl:ENSG00000070770 To verify the association of HDAC6 with CK2, we performed a pull-down assay using two recombinant proteins (GST–HDAC6 and CK2 holoenzyme) and individual subunit proteins (Fig. 2C, top). Only CK2 holoenzyme was found to be associated with HDAC6, whereas CK2α and CK2β alone failed to precipitate with HDAC6, indicating that the CK2 holoenzyme associates with HDAC6
SP1 GeneProduct ensembl:ENSG00000185591
FOXP3 GeneProduct ensembl:ENSG00000049768
CCDC141 GeneProduct ensembl:ENSG00000163492
HIF1A GeneProduct ensembl:ENSG00000100644
PRKN GeneProduct ensembl:ENSG00000185345
GARS1 GeneProduct ensembl:ENSG00000106105 Interestingly, pulldown experiments showed that HDAC6 can co-immunoprecipitate with HSPB1 (CMT2E) (Zhang et al., 2007), but also with GlyRS (CMT2D)
HSPB1 GeneProduct ensembl:ENSG00000106211
CTTN GeneProduct ensembl:ENSG00000085733
XRCC6 GeneProduct ensembl:ENSG00000196419
PRDX1 GeneProduct ensembl:ENSG00000117450
PRDX2 GeneProduct ensembl:ENSG00000167815
DNAJA1 GeneProduct ensembl:ENSG00000086061 Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity
TUBB GeneProduct ensembl:ENSG00000196230
TUBB3 GeneProduct ensembl:ENSG00000258947
TUBA1C GeneProduct ensembl:ENSG00000167553
TUBA3C GeneProduct ensembl:ENSG00000198033
SMAD7 GeneProduct ensembl:ENSG00000101665 Silencing HDAC6 increased SMAD7 protein expression
tat GeneProduct uniprot:155871
BAX GeneProduct ensembl:ENSG00000087088
VHL GeneProduct ensembl:ENSG00000134086
BCL2 GeneProduct ensembl:ENSG00000171791
VIM Protein ensembl:ENSG00000026025
MAP1B Protein ensembl:ENSG00000131711
SHH Protein ensembl:ENSG00000164690
HSPA4 Protein ensembl:ENSG00000170606
ITIH4 Protein ensembl:ENSG00000055955
PTK2B Protein ensembl:ENSG00000120899
MAP3K5 Protein ensembl:ENSG00000197442
SNCA Protein ensembl:ENSG00000145335
ATP13A2 Protein ensembl:ENSG00000159363
ARID3A Protein ensembl:ENSG00000116017
MDH1 Protein ensembl:ENSG00000014641
NDUFV1 Protein ensembl:ENSG00000167792
MIF Protein ensembl:ENSG00000240972
RHOT1 Protein ensembl:ENSG00000126858
CNOT6 Protein ensembl:ENSG00000113300

References

  1. HDAC6 is a microtubule-associated deacetylase. Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, et al. Nature. 2002 May 23;417(6887):455–8. PubMed Europe PMC Scholia
  2. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S. J Biol Chem. 2004 Feb 27;279(9):7685–91. PubMed Europe PMC Scholia
  3. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. Cell. 2003 Dec 12;115(6):727–38. PubMed Europe PMC Scholia
  4. The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation. Burnett BG, Pittman RN. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4330–5. PubMed Europe PMC Scholia
  5. The balance between acetylation and deacetylation controls Smad7 stability. Simonsson M, Heldin CH, Ericsson J, Grönroos E. J Biol Chem. 2005 Jun 10;280(23):21797–803. PubMed Europe PMC Scholia
  6. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. Iwata A, Riley BE, Johnston JA, Kopito RR. J Biol Chem. 2005 Dec 2;280(48):40282–92. PubMed Europe PMC Scholia
  7. Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Southwood CM, Peppi M, Dryden S, Tainsky MA, Gow A. Neurochem Res. 2007 Feb;32(2):187–95. PubMed Europe PMC Scholia
  8. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington’s disease by increasing tubulin acetylation. Dompierre JP, Godin JD, Charrin BC, Cordelières FP, King SJ, Humbert S, et al. J Neurosci. 2007 Mar 28;27(13):3571–83. PubMed Europe PMC Scholia
  9. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA. Cell. 2007 Jun 29;129(7):1351–63. PubMed Europe PMC Scholia
  10. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, et al. Mol Cell. 2007 Jul 20;27(2):197–213. PubMed Europe PMC Scholia
  11. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, et al. Genes Dev. 2007 Sep 1;21(17):2172–81. PubMed Europe PMC Scholia
  12. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. Olzmann JA, Li L, Chudaev MV, Chen J, Perez FA, Palmiter RD, et al. J Cell Biol. 2007 Sep 10;178(6):1025–38. PubMed Europe PMC Scholia
  13. Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Gao Y sheng, Hubbert CC, Lu J, Lee YS, Lee JY, Yao TP. Mol Cell Biol. 2007 Dec;27(24):8637–47. PubMed Europe PMC Scholia
  14. The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Kwon S, Zhang Y, Matthias P. Genes Dev. 2007 Dec 15;21(24):3381–94. PubMed Europe PMC Scholia
  15. Aggresome formation and neurodegenerative diseases: therapeutic implications. Olzmann JA, Li L, Chin LS. Curr Med Chem. 2008;15(1):47–60. PubMed Europe PMC Scholia
  16. HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Parmigiani RB, Xu WS, Venta-Perez G, Erdjument-Bromage H, Yaneva M, Tempst P, et al. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9633–8. PubMed Europe PMC Scholia
  17. Histone deacetylase 6 interacts with the microtubule-associated protein tau. Ding H, Dolan PJ, Johnson GVW. J Neurochem. 2008 Sep;106(5):2119–30. PubMed Europe PMC Scholia
  18. The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. Kalveram B, Schmidtke G, Groettrup M. J Cell Sci. 2008 Dec 15;121(Pt 24):4079–88. PubMed Europe PMC Scholia
  19. Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. Jiang Q, Ren Y, Feng J. J Neurosci. 2008 Nov 26;28(48):12993–3002. PubMed Europe PMC Scholia
  20. A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, et al. Dev Cell. 2008 Dec;15(6):854–65. PubMed Europe PMC Scholia
  21. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, et al. Cell. 2009 Jan 23;136(2):322–36. PubMed Europe PMC Scholia
  22. Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity. Han Y, Jeong HM, Jin YH, Kim YJ, Jeong HG, Yeo CY, et al. Biochem Biophys Res Commun. 2009 May 22;383(1):88–92. PubMed Europe PMC Scholia
  23. Tau--an inhibitor of deacetylase HDAC6 function. Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, et al. J Neurochem. 2009 Jun;109(6):1756–66. PubMed Europe PMC Scholia
  24. Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. Zilberman Y, Ballestrem C, Carramusa L, Mazitschek R, Khochbin S, Bershadsky A. J Cell Sci. 2009 Oct 1;122(Pt 19):3531–41. PubMed Europe PMC Scholia
  25. HDAC6 is a target for protection and regeneration following injury in the nervous system. Rivieccio MA, Brochier C, Willis DE, Walker BA, D’Annibale MA, McLaughlin K, et al. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599–604. PubMed Europe PMC Scholia
  26. IIp45 inhibits cell migration through inhibition of HDAC6. Wu Y, Song SW, Sun J, Bruner JM, Fuller GN, Zhang W. J Biol Chem. 2010 Feb 5;285(6):3554–60. PubMed Europe PMC Scholia
  27. HDAC6 regulates mitochondrial transport in hippocampal neurons. Chen S, Owens GC, Makarenkova H, Edelman DB. PLoS One. 2010 May 26;5(5):e10848. PubMed Europe PMC Scholia
  28. Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. Kim SH, Shanware NP, Bowler MJ, Tibbetts RS. J Biol Chem. 2010 Oct 29;285(44):34097–105. PubMed Europe PMC Scholia
  29. Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6. Into T, Inomata M, Niida S, Murakami Y, Shibata K ichiro. J Biol Chem. 2010 Nov 12;285(46):35759–69. PubMed Europe PMC Scholia
  30. Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development. Tapia M, Wandosell F, Garrido JJ. PLoS One. 2010 Sep 23;5(9):e12908. PubMed Europe PMC Scholia
  31. Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. Todd PK, Oh SY, Krans A, Pandey UB, Di Prospero NA, Min KT, et al. PLoS Genet. 2010 Dec 9;6(12):e1001240. PubMed Europe PMC Scholia
  32. Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress. Watabe M, Nakaki T. J Cell Sci. 2011 May 1;124(Pt 9):1519–32. PubMed Europe PMC Scholia
  33. HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma. Subramanian C, Jarzembowski JA, Opipari AW Jr, Castle VP, Kwok RPS. Neoplasia. 2011 Aug;13(8):726–34. PubMed Europe PMC Scholia
  34. HDAC6 regulates LPS-tolerance in astrocytes. Beurel E. PLoS One. 2011;6(10):e25804. PubMed Europe PMC Scholia
  35. The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis. Birdsey GM, Dryden NH, Shah AV, Hannah R, Hall MD, Haskard DO, et al. Blood. 2012 Jan 19;119(3):894–903. PubMed Europe PMC Scholia
  36. A novel GRK2/HDAC6 interaction modulates cell spreading and motility. Lafarga V, Aymerich I, Tapia O, Mayor F Jr, Penela P. EMBO J. 2012 Feb 15;31(4):856–69. PubMed Europe PMC Scholia
  37. Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex. Lee JB, Wei J, Liu W, Cheng J, Feng J, Yan Z. J Physiol. 2012 Apr 1;590(7):1535–46. PubMed Europe PMC Scholia
  38. HDAC6 at the Intersection of Neuroprotection and Neurodegeneration. d’Ydewalle C, Bogaert E, Van Den Bosch L. Traffic. 2012 Jun;13(6):771–9. PubMed Europe PMC Scholia
  39. HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. Espallergues J, Teegarden SL, Veerakumar A, Boulden J, Challis C, Jochems J, et al. J Neurosci. 2012 Mar 28;32(13):4400–16. PubMed Europe PMC Scholia
  40. Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. Cook C, Gendron TF, Scheffel K, Carlomagno Y, Dunmore J, DeTure M, et al. Hum Mol Genet. 2012 Jul 1;21(13):2936–45. PubMed Europe PMC Scholia
  41. Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Beier UH, Wang L, Han R, Akimova T, Liu Y, Hancock WW. Sci Signal. 2012 Jun 19;5(229):ra45. PubMed Europe PMC Scholia
  42. The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. Fusco C, Micale L, Egorov M, Monti M, D’Addetta EV, Augello B, et al. PLoS One. 2012;7(7):e40440. PubMed Europe PMC Scholia
  43. Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Mak AB, Nixon AML, Kittanakom S, Stewart JM, Chen GI, Curak J, et al. Cell Rep. 2012 Oct 25;2(4):951–63. PubMed Europe PMC Scholia
  44. Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes. Li Y, Shin D, Kwon SH. FEBS J. 2013 Feb;280(3):775–93. PubMed Europe PMC Scholia
  45. The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation. Tsai YC, Riess O, Soehn AS, Nguyen HP. PLoS One. 2012;7(12):e51999. PubMed Europe PMC Scholia
  46. HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation. Gal J, Chen J, Barnett KR, Yang L, Brumley E, Zhu H. J Biol Chem. 2013 May 24;288(21):15035–45. PubMed Europe PMC Scholia
  47. SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. Yan J, Seibenhener ML, Calderilla-Barbosa L, Diaz-Meco MT, Moscat J, Jiang J, et al. PLoS One. 2013 Sep 27;8(9):e76016. PubMed Europe PMC Scholia
  48. Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, et al. J Biol Chem. 2013 Nov 15;288(46):33156–70. PubMed Europe PMC Scholia
  49. Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, et al. Nat Commun. 2013;4:2532. PubMed Europe PMC Scholia
  50. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. Liesz A, Zhou W, Na SY, Hämmerling GJ, Garbi N, Karcher S, et al. J Neurosci. 2013 Oct 30;33(44):17350–62. PubMed Europe PMC Scholia
  51. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, et al. Elife. 2013 Dec 3;2:e01557. PubMed Europe PMC Scholia
  52. Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide. He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong JN, et al. Mol Biol Cell. 2014 Jun;25(11):1715–29. PubMed Europe PMC Scholia
  53. Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system. Watanabe Y, Khodosevich K, Monyer H. Cell Rep. 2014 Apr 24;7(2):552–64. PubMed Europe PMC Scholia
  54. Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, et al. Mol Immunol. 2014 Jul;60(1):44–53. PubMed Europe PMC Scholia
  55. HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release. Miskiewicz K, Jose LE, Yeshaw WM, Valadas JS, Swerts J, Munck S, et al. Cell Rep. 2014 Jul 10;8(1):94–102. PubMed Europe PMC Scholia
  56. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Falkenberg KJ, Johnstone RW. Nat Rev Drug Discov. 2014 Sep;13(9):673–91. PubMed Europe PMC Scholia
  57. Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors. Mangas-Sanjuan V, Oláh J, Gonzalez-Alvarez I, Lehotzky A, Tőkési N, Bermejo M, et al. Br J Pharmacol. 2015 Feb;172(3):829–40. PubMed Europe PMC Scholia
  58. Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. Zhang L, Liu S, Liu N, Zhang Y, Liu M, Li D, et al. Protein Cell. 2015 Jan;6(1):42–54. PubMed Europe PMC Scholia
  59. Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. Nakashima H, Nguyen T, Goins WF, Chiocca EA. J Biol Chem. 2015 Jan 16;290(3):1485–95. PubMed Europe PMC Scholia
  60. Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway. Dhanyamraju PK, Holz PS, Finkernagel F, Fendrich V, Lauth M. Mol Cancer Ther. 2015 Mar;14(3):727–39. PubMed Europe PMC Scholia
  61. aPKC phosphorylation of HDAC6 results in increased deacetylation activity. Du Y, Seibenhener ML, Yan J, Jiang J, Wooten MC. PLoS One. 2015 Apr 10;10(4):e0123191. PubMed Europe PMC Scholia
  62. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. Salian-Mehta S, Xu M, McKinsey TA, Tobet S, Wierman ME. J Biol Chem. 2015 May 29;290(22):14045–56. PubMed Europe PMC Scholia
  63. ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation. Sen A, Nelson TJ, Alkon DL. J Neurosci. 2015 May 13;35(19):7538–51. PubMed Europe PMC Scholia
  64. HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes. Youn GS, Ju SM, Choi SY, Park J. Glia. 2015 Nov;63(11):1953–65. PubMed Europe PMC Scholia
  65. Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling. Li S, Liu X, Chen X, Zhang L, Wang X. Tumour Biol. 2015 Dec;36(12):9661–5. PubMed Europe PMC Scholia
  66. HDAC6 Regulates the Chaperone-Mediated Autophagy to Prevent Oxidative Damage in Injured Neurons after Experimental Spinal Cord Injury. Su M, Guan H, Zhang F, Gao Y, Teng X, Yang W. Oxid Med Cell Longev. 2016;2016:7263736. PubMed Europe PMC Scholia
  67. SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6. Skoge RH, Ziegler M. J Cell Sci. 2016 Aug 1;129(15):2972–82. PubMed Europe PMC Scholia
  68. Chronic social defeat stress leads to changes of behaviour and memory-associated proteins of young mice. Jianhua F, Wei W, Xiaomei L, Shao-Hui W. Behav Brain Res. 2017 Jan 1;316:136–44. PubMed Europe PMC Scholia
  69. Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. Fukuda T, Nagashima S, Abe T, Kiyonari H, Inatome R, Yanagi S. EMBO Rep. 2016 Dec;17(12):1785–98. PubMed Europe PMC Scholia
  70. Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, et al. PLoS Genet. 2016 Dec 20;12(12):e1006486. PubMed Europe PMC Scholia
  71. HDAC6 regulates sensitivity to cell death in response to stress and post-stress recovery. Ryu HW, Won HR, Lee DH, Kwon SH. Cell Stress Chaperones. 2017 Mar;22(2):253–61. PubMed Europe PMC Scholia
  72. The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory. Perry S, Kiragasi B, Dickman D, Ray A. Cell Rep. 2017 Feb 7;18(6):1337–45. PubMed Europe PMC Scholia
  73. Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes. Youn GS, Cho H, Kim D, Choi SY, Park J. Redox Biol. 2017 Aug;12:978–86. PubMed Europe PMC Scholia
  74. Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. Iaconelli J, Lalonde J, Watmuff B, Liu B, Mazitschek R, Haggarty SJ, et al. ACS Chem Biol. 2017 Aug 18;12(8):2139–48. PubMed Europe PMC Scholia
  75. The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study. Sferra R, Pompili S, Festuccia C, Marampon F, Gravina GL, Ventura L, et al. Eur J Histochem. 2017 May 16;61(2):2732. PubMed Europe PMC Scholia
  76. N-terminal truncations of human bHLH transcription factor Twist1 leads to the formation of aggresomes. Govindarajalu G, Selvam M, Palchamy E, Baluchamy S. Mol Cell Biochem. 2018 Feb;439(1–2):75–85. PubMed Europe PMC Scholia
  77. Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury. Jian W, Wei X, Chen L, Wang Z, Sun Y, Zhu S, et al. Neurosci Lett. 2017 Sep 29;658:114–20. PubMed Europe PMC Scholia
  78. Paxillin regulates cell polarization and anterograde vesicle trafficking during cell migration. Dubois F, Alpha K, Turner CE. Mol Biol Cell. 2017 Dec 15;28(26):3815–31. PubMed Europe PMC Scholia
  79. HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway. Yang W, Liu Y, Gao R, Yu H, Sun T. Cancer Lett. 2018 Feb 28;415:164–76. PubMed Europe PMC Scholia
  80. HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease. Benoy V, Van Helleputte L, Prior R, d’Ydewalle C, Haeck W, Geens N, et al. Brain. 2018 Mar 1;141(3):673–87. PubMed Europe PMC Scholia
  81. Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer’s Disease. Mahady L, Nadeem M, Malek-Ahmadi M, Chen K, Perez SE, Mufson EJ. J Alzheimers Dis. 2018;62(1):115–31. PubMed Europe PMC Scholia
  82. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Mo Z, Zhao X, Liu H, Hu Q, Chen XQ, Pham J, et al. Nat Commun. 2018 Mar 8;9(1):1007. PubMed Europe PMC Scholia
  83. Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ. Acta Neuropathol Commun. 2018 Oct 1;6(1):103. PubMed Europe PMC Scholia
  84. Transactive response DNA binding protein of 43/histone deacetylase 6 axis alleviates H 2 O 2 -induced retinal ganglion cells injury through inhibiting apoptosis and autophagy. Yi EH, Xu F, Li P, Guo JQ. J Cell Biochem. 2019 Mar;120(3):4312–20. PubMed Europe PMC Scholia
  85. ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, et al. J Cell Biol. 2019 Jan 7;218(1):267–84. PubMed Europe PMC Scholia
  86. OCT4B-190 protects against ischemic stroke by modulating GSK-3β/HDAC6. Chen Y, Wu Z, Zhu X, Zhang M, Zang X, Li X, et al. Exp Neurol. 2019 Jun;316:52–62. PubMed Europe PMC Scholia
  87. Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. Kalinski AL, Kar AN, Craver J, Tosolini AP, Sleigh JN, Lee SJ, et al. J Cell Biol. 2019 Jun 3;218(6):1871–90. PubMed Europe PMC Scholia
  88. Developmental neurotoxicity in the context of multiple sevoflurane exposures: Potential role of histone deacetylase 6. Li G, Du J, Wang L, Shi X. Neurotoxicol Teratol. 2019;74:106813. PubMed Europe PMC Scholia
  89. Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120. Wenzel ED, Speidell A, Flowers SA, Wu C, Avdoshina V, Mocchetti I. Cell Death Dis. 2019 Sep 12;10(9):674. PubMed Europe PMC Scholia
  90. Exosomes from human urine-derived stem cells enhanced neurogenesis via miR-26a/HDAC6 axis after ischaemic stroke. Ling X, Zhang G, Xia Y, Zhu Q, Zhang J, Li Q, et al. J Cell Mol Med. 2020 Jan;24(1):640–54. PubMed Europe PMC Scholia
  91. Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation. Jian WX, Zhang Z, Zhan JH, Chu SF, Peng Y, Zhao M, et al. Acta Pharmacol Sin. 2020 May;41(5):588–98. PubMed Europe PMC Scholia
  92. The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, et al. Genes Dev. 2020 Feb 1;34(3–4):194–208. PubMed Europe PMC Scholia
  93. ATP depletion induced cochlear hair cells death through histone deacetylation in vitro. Fan B, Wang J, Zha D, Qiu J, Chen F. Neurosci Lett. 2020 May 14;727:134918. PubMed Europe PMC Scholia
  94. ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia. Ran J, Liu M, Feng J, Li H, Ma H, Song T, et al. Dev Cell. 2020 May 4;53(3):287-299.e5. PubMed Europe PMC Scholia
  95. Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma. Yang WB, Hsu CC, Hsu TI, Liou JP, Chang KY, Chen PY, et al. Neuro Oncol. 2020 Oct 14;22(10):1439–51. PubMed Europe PMC Scholia
  96. Histone deacetylase-6 modulates amyloid beta-induced cognitive dysfunction rats by regulating PTK2B. Liu Z, Hao KM, Wang HY, Qi WX. Neuroreport. 2020 Jul 10;31(10):754–61. PubMed Europe PMC Scholia
  97. Phospho-HDAC6 Gathers Into Protein Aggregates in Parkinson’s Disease and Atypical Parkinsonisms. Mazzetti S, De Leonardis M, Gagliardi G, Calogero AM, Basellini MJ, Madaschi L, et al. Front Neurosci. 2020 Jun 23;14:624. PubMed Europe PMC Scholia
  98. Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development. Kim JY, Hwang HG, Lee JY, Kim M, Kim JY. Mol Brain. 2020 Jul 25;13(1):105. PubMed Europe PMC Scholia
  99. Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, et al. Cell Death Dis. 2020 Oct 23;11(10):909. PubMed Europe PMC Scholia
  100. An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline. Trzeciakiewicz H, Ajit D, Tseng JH, Chen Y, Ajit A, Tabassum Z, et al. Nat Commun. 2020 Nov 2;11(1):5522. PubMed Europe PMC Scholia
  101. The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment. Lee S, Kwon Y, Kim S, Jo M, Jeon YM, Cheon M, et al. Front Cell Dev Biol. 2020 Nov 17;8:581942. PubMed Europe PMC Scholia
  102. Effects of velvet antler polypeptides on Alzheimer’s disease cell model via miR-613 HDAC6 pathway. Guo J, Lu M, Zhou Y, Wu B, Wu M. Pak J Pharm Sci. 2020 May;33(3(Special)):1427–33. PubMed Europe PMC Scholia
  103. DNA methyltransferase- and histone deacetylase-mediated epigenetic alterations induced by low-level methylmercury exposure disrupt neuronal development. Go S, Kurita H, Hatano M, Matsumoto K, Nogawa H, Fujimura M, et al. Arch Toxicol. 2021 Apr;95(4):1227–39. PubMed Europe PMC Scholia
  104. Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease. Roca-Agujetas V, Barbero-Camps E, de Dios C, Podlesniy P, Abadin X, Morales A, et al. Mol Neurodegener. 2021 Mar 8;16(1):15. PubMed Europe PMC Scholia
  105. HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations. Fazal R, Boeynaems S, Swijsen A, De Decker M, Fumagalli L, Moisse M, et al. EMBO J. 2021 Apr 1;40(7):e106177. PubMed Europe PMC Scholia
  106. Acetylation of NDUFV1 induced by a newly synthesized HDAC6 inhibitor HGC rescues dopaminergic neuron loss in Parkinson models. Li B, Yang Y, Wang Y, Zhang J, Ding J, Liu X, et al. iScience. 2021 Mar 17;24(4):102302. PubMed Europe PMC Scholia
  107. HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading. Xu L, Zhang L, Zhang X, Li G, Wang Y, Dong J, et al. Int J Mol Sci. 2021 Sep 29;22(19):10527. PubMed Europe PMC Scholia
  108. HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D). Smith AST, Kim JH, Chun C, Gharai A, Moon HW, Kim EY, et al. Adv Biol (Weinh). 2022 Feb;6(2):e2101308. PubMed Europe PMC Scholia
  109. Corticosterone-mediated regulation and functions of miR-218-5p in rat brain. Yoshino Y, Roy B, Dwivedi Y. Sci Rep. 2022 Jan 7;12(1):194. PubMed Europe PMC Scholia
  110. Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals. Saunders HAJ, Johnson-Schlitz DM, Jenkins BV, Volkert PJ, Yang SZ, Wildonger J. Curr Biol. 2022 Feb 7;32(3):614-630.e5. PubMed Europe PMC Scholia
  111. Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling. Balmik AA, Chinnathambi S. Eur J Cell Biol. 2022 Apr;101(2):151202. PubMed Europe PMC Scholia
  112. HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells. Wu AC, Yang WB, Chang KY, Lee JS, Liou JP, Su RY, et al. J Exp Clin Cancer Res. 2022 Feb 2;41(1):47. PubMed Europe PMC Scholia
  113. Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury. Hu JX, Ma WJ, He LY, Zhang CH, Zhang C, Wang Y, et al. Cell Death Dis. 2022 May 18;13(5):466. PubMed Europe PMC Scholia
  114. Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage. Wang M, Zhou C, Yu L, Kong D, Ma W, Lv B, et al. Cell Mol Life Sci. 2022 Jun 9;79(7):356. PubMed Europe PMC Scholia
  115. Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling. Li X, Saiyin H, Chen X, Yu Q, Ma L, Liang W. Mol Psychiatry. 2022 Nov 21;10.1038/s41380-022-01864–5. PubMed Europe PMC Scholia
  116. Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability. Pezzotta A, Brioschi L, Carbone S, Mazzoleni B, Bontempi V, Monastra F, et al. Int J Mol Sci. 2023 Mar 17;24(6):5771. PubMed Europe PMC Scholia