MYD88 distinct input-output pathway (WP3877)

Homo sapiens

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This pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 through canonical IKK phosphorylation. This complex also induces the production of reactive oxygen species. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3877 CPTAC Assay Portal].

Authors

AAR&Co , Friederike Ehrhart , Kristina Hanspers , Eric Weitz , and Alex Pico

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Toll-like receptor signaling pathway signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Reactive oxygen species Metabolite pubchem.compound:784
IRAK1 GeneProduct ensembl:ENSG00000184216
MYD88 GeneProduct ensembl:ENSG00000172936
TLR9 GeneProduct ensembl:ENSG00000239732
TLR6 GeneProduct ensembl:ENSG00000174130
TLR5 GeneProduct ensembl:ENSG00000187554
IL-1 GeneProduct ensembl:ENSG00000115008 Interleukin Not Specified
TLR1 GeneProduct ensembl:ENSG00000174125
TRAF6 GeneProduct ensembl:ENSG00000175104
TLR4 GeneProduct ensembl:ENSG00000136869
TIFA GeneProduct ensembl:ENSG00000145365
TLR7 GeneProduct ensembl:ENSG00000196664
TLR2 GeneProduct ensembl:ENSG00000137462
TLR10 GeneProduct ensembl:ENSG00000174123
NFKB GeneProduct ensembl:ENSG00000109320 NFKB NOt Specified
UEV1A GeneProduct ensembl:ENSG00000244687
UBC13 GeneProduct ensembl:ENSG00000177889
TLR8 GeneProduct ensembl:ENSG00000101916
AP-1 Protein uniprot:P05412

References

  1. Identification of potential pathway mediation targets in Toll-like receptor signaling. Li F, Thiele I, Jamshidi N, Palsson BØ. PLoS Comput Biol. 2009 Feb;5(2):e1000292. PubMed Europe PMC Scholia