Wnt signaling - Q neuroblast migration (WP2888)

Caenorhabditis elegans

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One of the functions of the Wnt-signaling pathway in the nematode Caenorhabditis elegans (C. elegans) is to control the proper anterior-posterior axis migration of descendants of the QL and QR neuroblasts. In wild type animals, Wnt signaling is activated in the QL neuroblast to induce expression of the Hox gene mab-5 resulting in the appropriate posterior migration of QL descendants. Any disruption in the Wnt signaling pathway leading to mab-5 expression results in erroneous anterior migration of QL neuroblast descendants.

Authors

Christian Grove , Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen

Activity

last edited

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Organisms

Caenorhabditis elegans

Communities

Annotations

Pathway Ontology

Wnt signaling pathway

Participants

Label Type Compact URI Comment
mab-5/Hox GeneProduct ensembl:WBGene00003102
MIG-1/Frizzled GeneProduct ensembl:WBGene00003238
PRY-1 GeneProduct ensembl:WBGene00004202
MAB-5/Hox GeneProduct ensembl:WBGene00003102
LIN-17/Frizzled GeneProduct ensembl:WBGene00003006
MIG-14/MOM-3Porcupine GeneProduct ensembl:WBGene00003246
MIG-5 GeneProduct ensembl:WBGene00003241
BAR-1/beta-Catenin GeneProduct ensembl:WBGene00000238
EGL-20/Wnt Protein ensembl:WBGene00001188

References

  1. Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration. Salser SJ, Kenyon C. Nature. 1992 Jan 16;355(6357):255–8. PubMed Europe PMC Scholia
  2. Regulation of anterior cell-specific mec-3 expression during asymmetric cell division in C. elegans. Way JC, Run JQ, Wang AY. Dev Dyn. 1992 Aug;194(4):289–302. PubMed Europe PMC Scholia
  3. Genetics of cell and axon migrations in Caenorhabditis elegans. Hedgecock EM, Culotti JG, Hall DH, Stern BD. Development. 1987 Jul;100(3):365–82. PubMed Europe PMC Scholia
  4. A gene involved in the development of the posterior body region of C. elegans. Kenyon C. Cell. 1986 Aug 1;46(3):477–87. PubMed Europe PMC Scholia
  5. Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. Harris J, Honigberg L, Robinson N, Kenyon C. Development. 1996 Oct;122(10):3117–31. PubMed Europe PMC Scholia
  6. A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Maloof JN, Whangbo J, Harris JM, Jongeward GD, Kenyon C. Development. 1999 Jan;126(1):37–49. PubMed Europe PMC Scholia
  7. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Korswagen HC, Coudreuse DYM, Betist MC, van de Water S, Zivkovic D, Clevers HC. Genes Dev. 2002 May 15;16(10):1291–302. PubMed Europe PMC Scholia
  8. Canonical and non-canonical Wnt signaling pathways in Caenorhabditis elegans: variations on a common signaling theme. Korswagen HC. Bioessays. 2002 Sep;24(9):801–10. PubMed Europe PMC Scholia
  9. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Oosterveen T, Coudreuse DYM, Yang PT, Fraser E, Bergsma J, Dale TC, et al. Dev Biol. 2007 Aug 15;308(2):438–48. PubMed Europe PMC Scholia