Mapk cascade (WP251)

Mus musculus

The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.

Authors

Nathan Salomonis , Ismael Reyes , Michiel Adriaens , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway

Participants

Label Type Compact URI Comment
GTP Metabolite cas:2564-35-4
GDP Metabolite cas:146-91-8
Mapk14 GeneProduct ensembl:ENSMUSG00000053436 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1432
Jun GeneProduct ensembl:ENSMUSG00000052684 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725
Nras GeneProduct ensembl:ENSMUSG00000027852 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4893
Raf1 GeneProduct ensembl:ENSMUSG00000000441 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5894
Map2k7 GeneProduct ensembl:ENSMUSG00000109061 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5609
Map3k3 GeneProduct ensembl:ENSMUSG00000020700 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4215
Map3k1 GeneProduct ensembl:ENSMUSG00000021754 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214
Mapk3 GeneProduct ensembl:ENSMUSG00000063065 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5595
Elk1 GeneProduct ensembl:ENSMUSG00000009406 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2002
Map2 GeneProduct ensembl:ENSMUSG00000015222 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4133
Map2k4 GeneProduct ensembl:ENSMUSG00000033352 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416
Hras GeneProduct ensembl:ENSMUSG00000025499 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3265
Map3k12 GeneProduct ensembl:ENSMUSG00000023050 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7786
Mapk10 GeneProduct ensembl:ENSMUSG00000046709 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5602
Map2k2 GeneProduct ensembl:ENSMUSG00000035027 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5605
Mbp GeneProduct ensembl:ENSMUSG00000041607 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4155
Mapk12 GeneProduct ensembl:ENSMUSG00000022610 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6300
Map2k6 GeneProduct ensembl:ENSMUSG00000020623 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5608
Sipa1 GeneProduct ensembl:ENSMUSG00000056917 not confirmed SwissProt ID - mu: SPA1 MOUSE
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6494
Mapk1 GeneProduct ensembl:ENSMUSG00000063358 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5594
Rasa3 GeneProduct ensembl:ENSMUSG00000031453 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:22821
Rras GeneProduct ensembl:ENSMUSG00000038387 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6237
Araf GeneProduct ensembl:ENSMUSG00000001127 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:369
Kras GeneProduct ensembl:ENSMUSG00000030265 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3845
Map3k2 GeneProduct ensembl:ENSMUSG00000024383 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10746
Braf GeneProduct ensembl:ENSMUSG00000002413 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:673
Map2k1 GeneProduct ensembl:ENSMUSG00000004936 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5604
Map2k3 GeneProduct ensembl:ENSMUSG00000018932 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5606
Plcb3 GeneProduct ensembl:ENSMUSG00000024960 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331

References

  1. Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR. IET Syst Biol. 2008 Jul;2(4):173–83. PubMed Europe PMC Scholia
  2. The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Plotnikov A, Zehorai E, Procaccia S, Seger R. Biochim Biophys Acta. 2011 Sep;1813(9):1619–33. PubMed Europe PMC Scholia