Wnt signaling pathway (WP97)

Drosophila melanogaster

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG].

Authors

Austin J. Carolo , Thomas Kelder , Daniela Digles , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Drosophila melanogaster

Communities

Annotations

Pathway Ontology

Wnt signaling pathway

Participants

Label Type Compact URI Comment
Cer GeneProduct ncbigene:37229
Wg GeneProduct uniprot:P09615
Fz2 GeneProduct uniprot:Q9VVX2
Dally GeneProduct uniprot:Q24114
Dsh GeneProduct uniprot:P51140
CK1,2 GeneProduct uniprot:Q9V462
Sgg GeneProduct uniprot:P18431
Axin GeneProduct uniprot:Q9V407
APC GeneProduct uniprot:Q9Y1T2
PP2A GeneProduct flybase:FBgn0042693
PP2c GeneProduct flybase:FBgn0022768
gbp GeneProduct uniprot:Q24055
Am GeneProduct uniprot:P18824
Hh GeneProduct uniprot:Q02936
pan GeneProduct flybase:FBgn0085432
Ci GeneProduct uniprot:P19538
Fu GeneProduct uniprot:P23647
Su(fu) GeneProduct uniprot:Q9VG38
Cos2 GeneProduct uniprot:Q9V4K0
CBP GeneProduct uniprot:O96676
Ptc GeneProduct uniprot:P18502
Dpp GeneProduct uniprot:Q9VQC6
Smo GeneProduct uniprot:P91682
Slmb GeneProduct uniprot:Q9VDE3
PKA GeneProduct flybase:FBgn0000273

References

  1. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia