Cytokines and inflammatory response (WP997)

Bos taurus

Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Sources: [http://www.biocarta.com/pathfiles/h_inflamPathway.asp BioCarta].

Authors

Thomas Kelder , Ferry Jagers , Christine Chichester , Alex Pico , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

inflammatory response pathway

Participants

Label Type Compact URI Comment
GRO1 GeneProduct ensembl:ENSBTAG00000037558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2920
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL1A GeneProduct ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
IL11 GeneProduct ensembl:ENSBTAG00000047400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3589
IL12B GeneProduct ensembl:ENSBTAG00000004741 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3593
CSF1 GeneProduct ensembl:ENSBTAG00000000283 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1435
CSF2 GeneProduct ensembl:ENSBTAG00000001570 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1437
CSF3 GeneProduct ensembl:ENSBTAG00000021462 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1440
CD4 GeneProduct ensembl:ENSBTAG00000003255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:920
IL10 GeneProduct ensembl:ENSBTAG00000006685 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3586
GRO1 GeneProduct ensembl:ENSBTAG00000037558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2919
IL15 GeneProduct ensembl:ENSBTAG00000018200 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3600
IL6 GeneProduct ensembl:ENSBTAG00000046456 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456
IL7 GeneProduct ensembl:ENSBTAG00000016284 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3574
IL4 GeneProduct ensembl:ENSBTAG00000015957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3565
IL13 GeneProduct ensembl:ENSBTAG00000015953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3596
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IL2 GeneProduct ensembl:ENSBTAG00000020883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3558
IL5 GeneProduct ensembl:ENSBTAG00000031235 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3567
PDGFA GeneProduct ensembl:ENSBTAG00000014541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5154
HLA-DRB1 GeneProduct ensembl:ENSBTAG00000038397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3123
BOLA-DRA GeneProduct ensembl:ENSBTAG00000010645 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3122

References

  1. Chemical biology of inflammatory cytokine signaling. Kataoka T. J Antibiot (Tokyo). 2009 Dec;62(12):655–67. PubMed Europe PMC Scholia