Type III interferon signaling (WP2113)
Homo sapiens
The recently identified type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2113 CPTAC Assay Portal].
Authors
Shamith Samarajiwa , Martina Summer-Kutmon , and Kristina HanspersActivity
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Cited In
- An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells (2022).
- Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 (2022).
- Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
Jak-Stat signaling pathway interleukin-29 signaling pathway interleukin-28A signaling pathway interleukin-28B signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IRF9 | GeneProduct | ncbigene:10379 | |
| IL28A | GeneProduct | ncbigene:282616 | |
| IL29 | GeneProduct | ncbigene:282618 | |
| IL28B | GeneProduct | ncbigene:282617 | |
| JAK1 | GeneProduct | ncbigene:3716 | |
| IL10RB | GeneProduct | ncbigene:3588 | |
| TYK2 | GeneProduct | ncbigene:7297 | |
| IL28RA | GeneProduct | ncbigene:163702 | |
| STAT1 | GeneProduct | ncbigene:6772 | |
| STAT2 | GeneProduct | ncbigene:6773 |