Estrogen signaling pathway (WP986)
Bos taurus
Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.
Authors
Alex Pico , Egon Willighagen , and Martina Summer-KutmonActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
estrogen signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Estradiol | Metabolite | hmdb:HMDB0000151 | |
| Growth factors | Metabolite | hmdb:HMDB0000151 | |
| Cyclic AMP | Metabolite | hmdb:HMDB0000058 | |
| FOS | GeneProduct | ensembl:ENSBTAG00000004322 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353 |
| SP1 | GeneProduct | ensembl:ENSBTAG00000003021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2099 |
| ELK1 | GeneProduct | ensembl:ENSBTAG00000015817 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002 |
| MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030 |
| GPER1 | GeneProduct | ensembl:ENSBTAG00000048154 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2852 |
| JUN | GeneProduct | ensembl:ENSBTAG00000004037 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725 |
| PIK3CA | GeneProduct | ensembl:ENSBTAG00000009232 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290 |
| NFKB1 | GeneProduct | ensembl:ENSBTAG00000020270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790 |
| BCL2 | GeneProduct | ensembl:ENSBTAG00000019302 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596 |
| GNGT1 | GeneProduct | ensembl:ENSBTAG00000002674 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792 |
| GNB1 | GeneProduct | ensembl:ENSBTAG00000000215 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782 |
| AKT1 | GeneProduct | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| CREB1 | GeneProduct | ensembl:ENSBTAG00000005474 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385 |
| BRAF | GeneProduct | ensembl:ENSBTAG00000021761 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673 |
| MAPK9 | GeneProduct | ensembl:ENSBTAG00000004709 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601 |
| GNAS | GeneProduct | ensembl:ENSBTAG00000017475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778 |
| MAPK14 | GeneProduct | ensembl:ENSBTAG00000020783 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432 |
| MAP2K1 | GeneProduct | ensembl:ENSBTAG00000033983 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032 |
| PRKACA | GeneProduct | ensembl:ENSBTAG00000006642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566 |
| CHUK | GeneProduct | ensembl:ENSBTAG00000007591 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147 |
| IKBKB | GeneProduct | ensembl:ENSBTAG00000007599 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551 |
| IKBKG | GeneProduct | ensembl:ENSBTAG00000006268 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517 |
References
- TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
- IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
- Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia