Heterochronic gene regulation of development (WP2227)

Caenorhabditis elegans

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The heterochronic pathway, regulating larval development in Caenorhabditis elegans, is shown. Caenorhabditis elegans is a good model for studying heterochronic genes,due to its invariant cell lineages. Heterochronic is associated with the development of cells or tissues at a "different" time relative to other developmental events. Changes in developmental timing are thought to be a driving force of morphological evolution. Regulatory relationships shown here are supported by genetic data, but not all are direct. Lin-42 is not shown, as its complex expression pattern and genetic interactions suggest that it acts at multiple steps through out the pathways, making its precise placement difficult. In the absence of ligand DAF-12 represses let-7 family miRNAs. Arrows indicate activation - Bars indicate repression.

Authors

Karen Yook , Asios Olia , Friederike Ehrhart , Kristina Hanspers , Denise Slenter , Alex Pico , and Egon Willighagen

Activity

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Organisms

Caenorhabditis elegans

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development signaling pathway

Participants

Label Type Compact URI Comment
LIN-66 GeneProduct ensembl:WBGene00001562
LIN-14 GeneProduct ensembl:WBGene00003003
LIN-28 GeneProduct ensembl:WBGene00003014
DAF-12 GeneProduct ensembl:WBGene00000908
LIN-46 GeneProduct ensembl:WBGene00003031
HBL-1 GeneProduct ensembl:WBGene00001824
LIN-41 GeneProduct ensembl:WBGene00003026
LIN-29 GeneProduct ensembl:WBGene00003015

References

  1. Heterochronic genes. Abbott AL. Curr Biol. 2003 Oct 28;13(21):R824-5. PubMed Europe PMC Scholia
  2. Heterochronic genes and the nature of developmental time. Moss EG. Curr Biol. 2007 Jun 5;17(11):R425-34. PubMed Europe PMC Scholia
  3. miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans. Resnick TD, McCulloch KA, Rougvie AE. Dev Dyn. 2010 May;239(5):1477–89. PubMed Europe PMC Scholia