Thyroid hormone imbalance leading to neurodevelopmental abnormalities (WP5227)

Homo sapiens

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Adverse outcome pathway for the effect of thyroid hormone disruption. This AOP network is based on the human-relevant AOPs in AOP-Wiki that involve thyroid hormone and neurological adverse outcomes.

Authors

Celine Malyar , Marvin Martens , Eric Weitz , and Egon Willighagen

Activity

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Organisms

Homo sapiens

Communities

Adverse Outcome Pathways

Annotations

Pathway Ontology

thyroid hormone biosynthetic pathway thyroid hormone signaling pathway

Cell Type Ontology

GABAergic interneuron oligodendrocyte

Participants

Label Type Compact URI Comment

References

  1. Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments? Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, et al. Crit Rev Toxicol. 2020 Oct;50(9):740–63. PubMed Europe PMC Scholia
  2. Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments? Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, et al. Crit Rev Toxicol. 2021 Apr;51(4):328–58. PubMed Europe PMC Scholia