Macrophage-stimulating protein (MSP) signaling (WP5353)

Homo sapiens

Authors

Rex D A B , Aishwarya Iyer , Alex Pico , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

breast cancer pathway cancer pathway

Disease Ontology

ovarian disease prostate cancer ovarian cancer endometrial cancer breast cancer

Cell Type Ontology

osteoblast

References

1. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. Iwama A, Yamaguchi N, Suda T. EMBO J. 1996 Nov 1;15(21):5866–75. PubMed Europe PMC Scholia
2. Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism. Danilkovitch A, Skeel A, Leonard EJ. Exp Cell Res. 1999 May 1;248(2):575–82. PubMed Europe PMC Scholia
3. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells. Danilkovitch A, Donley S, Skeel A, Leonard EJ. Mol Cell Biol. 2000 Mar;20(6):2218–27. PubMed Europe PMC Scholia
4. RON-regulated innate immunity is protective in an animal model of multiple sclerosis. Tsutsui S, Noorbakhsh F, Sullivan A, Henderson AJ, Warren K, Toney-Earley K, et al. Ann Neurol. 2005 Jun;57(6):883–95. PubMed Europe PMC Scholia
5. Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release and NF-kappaB pathway. Gunella G, Bardelli C, Amoruso A, Viano I, Balbo P, Brunelleschi S. Br J Pharmacol. 2006 Jun;148(4):478–89. PubMed Europe PMC Scholia
6. Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence. Côté M, Miller AD, Liu SL. Biochem Biophys Res Commun. 2007 Aug 17;360(1):219–25. PubMed Europe PMC Scholia
7. Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility. Zhang K, Yao HP, Wang MH. Carcinogenesis. 2008 Mar;29(3):552–9. PubMed Europe PMC Scholia
8. The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity. Wilson CB, Ray M, Lutz M, Sharda D, Xu J, Hankey PA. J Immunol. 2008 Aug 15;181(4):2303–10. PubMed Europe PMC Scholia
9. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. Chanda D, Li T, Song KH, Kim YH, Sim J, Lee CH, et al. J Biol Chem. 2009 Oct 16;284(42):28510–21. PubMed Europe PMC Scholia
10. The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. Thobe MN, Gurusamy D, Pathrose P, Waltz SE. Oncogene. 2010 Jan 14;29(2):214–26. PubMed Europe PMC Scholia
11. Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein. Ma Q, Guin S, Padhye SS, Zhou YQ, Zhang RW, Wang MH. Mol Cancer. 2011 May 28;10:66. PubMed Europe PMC Scholia
12. The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer. Zhao H, Chen MS, Lo YH, Waltz SE, Wang J, Ho PC, et al. Oncogene. 2014 Mar 13;33(11):1429–37. PubMed Europe PMC Scholia
13. Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages. Chaudhuri A, Wilson NS, Yang B, Paler Martinez A, Liu J, Zhu C, et al. Immunol Cell Biol. 2013 Aug;91(7):451–60. PubMed Europe PMC Scholia
14. The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming. Cunha S, Lin YC, Goossen EA, DeVette CI, Albertella MR, Thomson S, et al. Cell Rep. 2014 Jan 16;6(1):141–54. PubMed Europe PMC Scholia
15. Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele. Kauder SE, Santell L, Mai E, Wright LY, Luis E, N’Diaye EN, et al. PLoS One. 2013 Dec 23;8(12):e83958. PubMed Europe PMC Scholia
16. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, et al. Oncogene. 2015 Apr 30;34(18):2325–36. PubMed Europe PMC Scholia
17. Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Moxley KM, Wang L, Welm AL, Bieniasz M. Genes Cancer. 2016 May;7(5–6):169–81. PubMed Europe PMC Scholia
18. MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Chanda D, Li J, Oligschlaeger Y, Jeurissen MLJ, Houben T, Walenbergh SMA, et al. Exp Mol Med. 2016 Sep 9;48(9):e258. PubMed Europe PMC Scholia
19. A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells. Ling Y, Kuang Y, Chen LL, Lao WF, Zhu YR, Wang LQ, et al. Oncotarget. 2017 Jun 13;8(24):39101–16. PubMed Europe PMC Scholia
20. Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d’origine nantais dependent GAB1/Src/β-catenin pathway activation in a mouse model. Lu T, Wang Z, Prativa S, Xu Y, Wang T, Zhang Y, et al. J Neurochem. 2019 Jan;148(1):114–26. PubMed Europe PMC Scholia
21. mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential. Faham N, Zhao L, Welm AL. NPJ Breast Cancer. 2018 Nov 9;4:36. PubMed Europe PMC Scholia
22. When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All? Baird AM, Easty D, Jarzabek M, Shiels L, Soltermann A, Klebe S, et al. Front Endocrinol (Lausanne). 2019 Feb 26;10:89. PubMed Europe PMC Scholia
23. RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells. Park JS, Choi HI, Kim DH, Kim CS, Bae EH, Ma SK, et al. Int J Mol Sci. 2019 Nov 4;20(21):5489. PubMed Europe PMC Scholia
24. Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer. Wang Z, Yang Y, Hu S, He J, Wu Z, Qi Z, et al. Cell Biol Toxicol. 2021 Feb;37(1):35–49. PubMed Europe PMC Scholia
25. Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway. Jeong BC, Oh SH, Lee MN, Koh JT. J Bone Metab. 2020 Nov;27(4):267–79. PubMed Europe PMC Scholia
26. RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma. Yu Q, Wang J, Li T, Xu X, Guo X, Ding S, et al. Biomed Res Int. 2021 Oct 19;2021:2282916. PubMed Europe PMC Scholia