Apoptosis (WP254)

Homo sapiens

Authors

Alexander C. Zambon , Alex Pico , Thomas Kelder , Susan Coort , Angelika , Beth Lawlor , Martijn Van Iersel , Marc Gillespie , Kristina Hanspers , Jildau Bouwman , Anders Riutta , Nuno , Egon Willighagen , Martina Summer-Kutmon , Marianthi Kalafati , Josip , Anam , and Eric Weitz

Activity

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Cited In

• Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease (2022).
• ConsensusPathDB 2022: molecular interactions update as a resource for network biology (2022).
• Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts (2021).
• Transcriptome Signature of Immune Cells Post Reovirus Treatment in KRAS Mutated Colorectal Cancer (2021).
• TOX is a critical regulator of tumour-specific T cell differentiation (2020).
• Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas (2017).
• MicroRNA expression profiling of Xp11 renal cell carcinoma (2017).
• Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
• Computational modeling of drug response with applications to neuroscience (2014).
• A network biology workflow to study transcriptomics data of the diabetic liver (2014).
• Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis (2013).
• GediNET for discovering gene associations across diseases using knowledge based machine learning approach (2022).
• CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis (2022).
• A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
• A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.
• Construction and analysis of protein-protein interaction network of non-alcoholic fatty liver disease.
• A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis (2024).
• Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).

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Organisms

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology

apoptotic cell death pathway cell death pathway regulatory pathway

References

1. Regulation of p53 in response to DNA damage. Lakin ND, Jackson SP. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
2. mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
3. The p53-MDM2 network: from oscillations to apoptosis. Bose I, Ghosh B. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
4. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia