FAS pathway and stress induction of HSP regulation (WP1138)

Canis familiaris

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This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].

Authors

Thomas Kelder , Kristina Hanspers , Christine Chichester , Egon Willighagen , Andra Waagmeester , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

FasL mediated signaling pathway stress response pathway

Participants

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Ceramide Metabolite cas:104404-17-3
SPTAN1 GeneProduct ncbigene:403484 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
IL1A GeneProduct ncbigene:403782
FAF1 GeneProduct ncbigene:608231
HSPB1 GeneProduct ncbigene:403979
RIPK2 GeneProduct ncbigene:477936 receptor (TNFRSF)-interacting serine-threonine kinase 2
DFFB GeneProduct ncbigene:489623
PAK1 GeneProduct ncbigene:607885
APAF1 GeneProduct ncbigene:482620
DAXX GeneProduct ncbigene:474873
MAPKAPK2 GeneProduct ncbigene:490263
CASP8 GeneProduct ncbigene:488473
PARP1 GeneProduct ncbigene:490385
DFFA GeneProduct ncbigene:487449
ARHGDIB GeneProduct ncbigene:486666 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
CYCS GeneProduct ncbigene:475258
FASLG GeneProduct ncbigene:442968
CASP10 GeneProduct ncbigene:488472
RB1 GeneProduct ncbigene:476915
MAPK8 GeneProduct ncbigene:477746
JUN GeneProduct ncbigene:609429
MAPKAPK3 GeneProduct ncbigene:484756
CASP6 GeneProduct ncbigene:487899
PAK2 GeneProduct ncbigene:612814
LMNB1 GeneProduct ncbigene:474663
LMNB2 GeneProduct ncbigene:485070
CASP9 GeneProduct ncbigene:487432
CFLAR GeneProduct ncbigene:488471
BCL2 GeneProduct ncbigene:403416
MAP3K1 GeneProduct ncbigene:478061
CASP3 GeneProduct ncbigene:403567
TNF GeneProduct ncbigene:403922
PRKDC GeneProduct ncbigene:474176
LMNA GeneProduct ncbigene:480124
FAS GeneProduct ncbigene:486469

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia