Toll-like receptor signaling related to MyD88 (WP3858)

Homo sapiens

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TLR and NFkB are important in inflammation in the body and in the cancerous cells. TLR signaling pathways are usually connected with MyD88 dependent pathways and MyD88 independent pathways. TLR pathways that involve MyD88 dependent pathways such as this one involve IRAK complexes. The finding of TLR or NFkB genes within the body usually correlates with breast cancer within the person. This pathway is based on the figure 1 of “Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study” (see bibliography). Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

Authors

AAR&Co , Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , Denise Slenter , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

breast cancer pathway cancer pathway disease pathway Toll-like receptor signaling pathway immune response pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
TICAM2 GeneProduct ensembl:ENSG00000243414
TLR4 GeneProduct ensembl:ENSG00000136869
IRAK4 GeneProduct ensembl:ENSG00000198001
RELA GeneProduct ncbigene:5970
NFKB2 GeneProduct ensembl:ENSG00000077150
TBK1 GeneProduct ensembl:ENSG00000183735
RELB GeneProduct ncbigene:5971
TLR2 GeneProduct ensembl:ENSG00000137462
c-REL GeneProduct ncbigene:5966
TLR6 GeneProduct ensembl:ENSG00000174130
IRAK1 GeneProduct ensembl:ENSG00000184216
TLR8 GeneProduct ensembl:ENSG00000101916
MYD88 GeneProduct ensembl:ENSG00000172936
TLR9 GeneProduct ensembl:ENSG00000239732
IKBKE GeneProduct ensembl:ENSG00000263528
TLR5 GeneProduct ensembl:ENSG00000187554
IRF3 GeneProduct ensembl:ENSG00000126456
TICAM1 GeneProduct ensembl:ENSG00000127666
TLR7 GeneProduct ensembl:ENSG00000196664
TOLLIP GeneProduct ensembl:ENSG00000078902
TIRAP GeneProduct ensembl:ENSG00000150455
TRAF3 GeneProduct ensembl:ENSG00000131323
MAPK1 GeneProduct ensembl:ENSG00000100030
NFKB1 GeneProduct ensembl:ENSG00000109320
TLR3 GeneProduct ensembl:ENSG00000164342
IRF7 GeneProduct ensembl:ENSG00000185507
TRAF6 GeneProduct ensembl:ENSG00000175104
TLR1 GeneProduct ensembl:ENSG00000174125
IKBKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
IKBKG GeneProduct ensembl:ENSG00000269335

References

  1. Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study. Resler AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, et al. BMC Cancer. 2013 May 1;13:219. PubMed Europe PMC Scholia